tool compound

EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).

Atinvicitinib, a selective Janus kinase (JAK) inhibitor, demonstrates high specificity for Janus kinase 1 (JAK1), consequently inhibiting downstream cytokine signaling pathways that rely on JAK1 enzymatic activity. Atinvicitinib modulates a wide range of cytokines that are implicated in itch responses, allergic reactions, and inflammatory conditions, making it a significant research tool for studying cytokine-mediated immune processes as well as therapeutic modulation of allergic and inflammatory diseases.

3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in the study of neurological disorders and cancer.

BRK inhibitor P21d hydrochloride is a highly potent inhibitor of breast tumor kinase (BRK/PTK6), displaying an IC50 of 30 nM, and effectively suppresses p-SAM68 with an IC50 of 52 nM. This compound serves as a valuable tool for evaluating BRK inhibitors' efficacy in xenograft breast tumor models, enabling in vivo activity assessment.

CC214-1 is an mTOR inhibitor with potential anticancer activity, inhibits protein translation, and induces autophagy. CC214-1 is an in vitro tool compound for exploring the biology of mTOR kinases and can be used to study myeloma.

JAK3-IN-11 (Compound 12) exhibits potent, noncytotoxic, irreversible, orally active JAK3 inhibitory activity (IC50 = 1.7 nM) with an excellent selectivity profile (>588-fold compared to other JAK isoforms), covalently binds to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T-cell proliferation which is a promising tool for studying autoimmune diseases [1].

2-Acetoxyacetophenone is an organic ester compound that is commonly employed as a reagent and biochemical tool in the field of proteomics research, with additional potential applications in specialized chemical synthesis and various branches of medical research.

5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione (5-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione) is a synthetic compound. It has been used as a catalyst and as a tool in enzyme kinetic studies; it has also been used in studies of enzyme inhibition, as well as in drug receptor interaction studies.

Compound 84163-77-9 is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 84163-77-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

GABAA receptor agent 5 demonstrates antagonist activity across multiple GABAA receptor subtypes, and GABAA receptor agent 5 exhibits IC50 values of 0.24, 0.088, 0.068, 0.33, 0.79, 0.32, 0.079, and 0.051 μM for α1β2δ, α4β1δ, α4β2δ, α6β2δ, α1β2γ2, α2β2γ2, α3β2γ2, and α5β2γ2 receptor configurations, respectively. GABAA receptor agent 5 (compound 018) thereby provides a precise pharmacological tool for characterizing subtype-selective GABAA receptor inhibition and supports mechanistic neuropharmacology studies focused on inhibitory synaptic signaling and therapeutic antagonist development.

Tebideutorexant is a selective antagonist of the orexin-1 receptor and has demonstrated anti-panic effects in both rodent and human models of panic-anxiety. Tebideutorexant provides valuable insights into orexin signaling pathways in stress response and has potential utility as a tool compound for psychiatric and neurobehavioral disorder research.

FLA-99 is a biochemical compound that selectively inhibits the enzymatic breakdown of inositol-1,4,5-triphosphate (IP3) by inositol-1,4,5-triphosphate 5-phosphatase. By preventing IP3 degradation, FLA-99 modulates intracellular calcium signaling, making it a useful tool in signal transduction and phosphoinositide pathway research.

Pyrrothiogatain, with CAS No. 477888-48-5, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13356 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound 837392-64-0 is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 837392-64-0 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound 69627-03-8 is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 69627-03-8 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Compound CC50616, with CAS No. 884507-31-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound CC50616 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5-PT (5-Propargyltryptamide) is an alkynylated 5-HT analog that can undergo bioorthogonal click chemistry (e.g., azide-alkynyl cycloaddition reactions) used in neuroscience research as a tool compound or probe to track down proteins interacting with 5-PT and to explore the mechanism of 5-hydroxytryptamine's action in cells.

RR-11a is a synthetic enzyme legumain inhibitor. This compound specifically targets and inhibits the activity of legumain, an enzyme implicated in various biological processes. RR-11a's synthetic nature allows for precise modulation of legumain activity, making it a valuable tool in biochemical research and potential therapeutic applications.

BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride is a chemical compound comprising an IAP ligand that targets the E3 ubiquitin ligase and a PROTAC linker, mainly used in the development of SNIPERs for targeted protein degradation[1].

N-(Amino-PEG4)-N-Biotin-PEG4-acid is a PEG-based PROTAC linker incorporating biotin for labeling, making it a versatile tool in PROTAC synthesis[1].

Pomalidomide-amido-C1-Br is a synthesized conjugate consisting of the Pomalidomide-based cereblon ligand and a linker, functioning as an E3 ligase ligand-linker. This compound serves as a tool for designing a B-Raf PROTAC degrader, specifically PROTAC B-Raf degrader 1, which exhibits anti-cancer activity[1].

NEU3-IN-2 (compound 963), a derivative of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) and a C9 biphenylcarbamate, functions as an inhibitor of NEU3, a human neuraminidase with four isozymes. This compound exhibits inhibitory activity with a Ki of 0.12 μM and an IC50 of 0.31 μM. It serves as a crucial tool in the exploration of NEU3 isozyme functionality. Additionally, its analogs, featuring an amide and a triazole linker, show selectivity towards NEU1 and NEU4 isozymes, respectively.

AGH-192, an efficient agonist with compound-like properties, may serve as an ideal tool compound for studying 5-HT7 receptor functions. Furthermore, its observed analgesic effects in a murine neuropathic pain model indicate its potential as a pain-relieving medication.