t145

T145 inhibits growth of Enterococcus faecalis, Staphylococcus aureus and Mycobacterium tuberculosis (Mtb) with sub μg/ml potencies that are potentially therapeutically valuable. T145 minimizes selection of spontaneous resistant mutants, a trait that prolo

BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM).

AT-1459 is a novel direct thrombin inhibitor with antithrombotic efficacy.

Compound 1b, also known as Antibacterial agent 145, targets the bacterial iron uptake pathway to exert its effects. It compromises the integrity of the bacterial cytoplasmic membrane and inhibits cellular metabolism while demonstrating minimal cytotoxicity to normal cells [1].

Compound Ir5 (Antitumor agent-145) serves as a tumor inhibitor characterized by significant fluorescence and mitochondrial targeting. It promotes anti-cancer activity by inducing necroptosis and stimulating the necroptosis-related immune response [1].