sesquiterpene

(-)-Cedrene (Alpha-Cedrene) is a sesquiterpene from cedar oil that has anti-leukemia, antibacterial and anti-obesity properties.

Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative stress, mitochondrial dysfunction, and apoptosis by modulating the PI3K AKT GSK-3β signaling pathways.

Ainsliadimer A, a sesquiterpene lactone dimer from Ainsliaea macrocephala, has antitumour activity and induces cell death in various cancer cells.

Cedrene (AI3-51328), a type sesquiterpene compound derived from Xylaria guizhouensis NJAU4742, promotes lateral root formation in plants and acts through growth hormone transport and signaling.

trans-Nerolidol is a sesquiterpene alcohol isolated from the above-ground parts of the Saharan Valerian plant with antifungal activity. trans-Nerolidol inhibits cell proliferation in a dose-dependent manner, and induces cell cycle arrest in the G1 phase.

(E)-β-Farnesene (trans-β-Farnesene) is a sesquiterpene hydrocarbon found in Phlomis aurea Decne, serving as the primary component of many aphid alarm pheromones that disrupt feeding. It also impairs the development and survival of Chilo suppressalis larvae by disrupting their hormone balance.

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco. It is a close analog of Sclareol, a plant antifungal compound.

Bilobalide ((-)-Bilobalide), a bioactive from Gingko Biloba, is active on hypoxia-induced alterations.

Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-κB inhibitor and also specifically inhibits HDAC1 protein, but is inactive against other class I II HDACs. Parthenolide has anti-inflammatory, anti-tumor, and anti-viral activities.

Nerolidol acetate is a natural sesquiterpene with anti-cancer, anti-inflammatory, antibacterial and anti-insect activities. Nerolidol acetate can inhibit parasite activity and inhibit schistosomiasis, nematodes, malaria, etc. Nerolidol acetate protects cells from oxidative damage to lipids, proteins and DNA, and has a protective effect on mouse hippocampal nerve cells.

Artemisinin (Qinghaosu) is a natural product, a sesquiterpene lactone, derived from Artemisia annua. Artemisinin has anti-malarial activity, as well as neuroprotective and anti-tumor activity.

5α-Hydroxycostic acid, a naturally occurring sesquiterpene, inhibits choroidal neovascularization in rats through dual signaling pathways mediated by VEGF VEGFR and Ang2 Tie2 (angiopoietin 2), and exhibits anti-inflammatory and anti-angiogenic effects on human breast cancer cells

Santalene is a fragrance sesquiterpene that is responsible for the fragrance of sandalwood oil.

Fuegin is a sesquiterpene compound isolated from the Polygonaceae plant Polygonum hydropiper.

Bisabolene (FEMA 3331) is a sesquiterpene extracted from oregano and other aromatic plants. It is a potential anticancer agent and studies have shown that it can induce apoptosis in the A549 cancer cell line.

Gochnatiolide A is a dimeric sesquiterpene derived from plants such as Ainsliaea henryi, exhibiting significant antiproliferative activity against various cancer cell lines, including renal, melanoma, ovarian-resistant, and glioma cells.

Tagitinin A is a naturally occurring sesquiterpene lactone compound that acts as a dual agonist of peroxisome proliferator-activated receptor α γ (PPARα PPARγ) and exerts antihyperglycemic and antihyperlipidemic effects in diabetes research.Tagitinin A is able to bind directly to the ligand-binding domain of PPARγ (IC50=55 μM), and also stimulates the PPAR Tagitinin A can directly bind to the PPARγ ligand binding domain (IC50=55 μM) and also stimulate the PPARα-dependent activation of the SULT2A1 gene promoter. As a phytotoxin, Tagitinin A significantly inhibited the growth of wheat germ sheath.

Secoaristolenedioic acid (Compound 1) is a sesquiterpene identified in the ethanol extract of the roots and rhizomes of Nardostachys chinensis.

Helenalin is a selective inhibitor of transcription factor NF-κB by direct targeting of p65. It is an anti-inflammatory sesquiterpene lactone compound with alkylating activity. Through its ability to target the cysteine sulfhydryl groups in the p65 subunit of NF-κB, helenalin effectively inhibits its DNA binding.

Gamma-Gurjunene is a sesquiterpene that can be isolated from Gurjun balsam.

Pterosin A-2-O-glucoside, a sesquiterpene glucoside, is potentially a degradation product of an illudane-type diglucoside.

T-Cadinol (Cedrelanol) is a sesquiterpene compound isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity and potential anticancer activity, inhibits trypanosomes and flagellomorphs, induces dendritic cells and drives Th1 polarization in human monocytes.T-Cadinol is a calcium antagonist that relaxes the contraction of 60 mM K+ induced by T-Cadinol in a concentration-dependent manner. 60 mM K+-induced contraction.

8-epi-Helenalin, a sesquiterpene lactone with anti-tumor properties, is derived from Inula britannica L. var. chinensis (Rupr.) Reg. It demonstrates cytotoxic activity against a range of cancer cell lines, with ED50 values of 12.2 μM for HL-60, 53.8 μM for A549, 9.1 μM for MCF7, 8.7 μM for HCT-15, 18.7 μM for SK-OV-3, and 8.3 μM for Malme-3M, indicating its potential for anti-tumor research [1].