p21 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6839	FRAX1036		PAK
	FRAX-1036 is a effective and selective PAK1 inhibitor.		PAK
T16367	NVS-PAK1-1		PAK
	NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).		PAK
T6840	FRAX486		PAK
	FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.		PAK
T11342L	G-5555		PAK
	G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).		PAK
T6546	IPA-3	IPA3,IPA 3	PAK
	IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).		PAK
T6014	FRAX597		PAK
	FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).		PAK
T16429	GNE 2861		PAK
	GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity.		PAK
T9698	UC2288		Mdm2 , p53
	UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.		Mdm2 , p53
T7697	BIX-01294		Histone Methyltransferase , Autophagy
	BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).		Histone Methyltransferase , Autophagy
T7539	O6-Benzylguanine		Apoptosis , DNA Alkylation , DNA/RNA Synthesis
	O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.		Apoptosis , DNA Alkylation , DNA/RNA Synthesis
T11826	LCH-7749944	GNF-PF-2356	Apoptosis , PAK
	LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. LCH-7749944 is a potent PAK4 inhibitor w...		Apoptosis , PAK
T1959	BIX-01294 trihydrochloride	BIX 01294	Histone Methyltransferase , Autophagy
	BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.		Histone Methyltransferase , Autophagy
T2539	Fingolimod hydrochloride	Fingolimod (FTY720) HCl,FTY720	TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
	Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).		TRP/TRPV Channel , S1P Receptor , PAK , LPL Receptor
T12472	Pifithrin-α, p-Nitro, Cyclic	PFN-α	p53
	Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.		p53
T6626	PF-3758309	PF-309,PF-03758309,PF 3758309	Apoptosis , PAK
	PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.		Apoptosis , PAK
T4230	PF-3758309 hydrochloride	PF-03758309 hydrochloride	Apoptosis , PAK
	PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd...		Apoptosis , PAK
T8678	Naphthazarin	5,8-Dihydroxy-1,4-naphthoquinone,DHNQ	Apoptosis
	Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter...		Apoptosis
T0646	5-Aminosalicylic Acid	Mesalazine,5-ASA,Mesalamine	NF-κB , Lipoxygenase , COX , Glutathione Peroxidase , Endogenous Metabolite , PAK , PPAR
	5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
T7939	Fingolimod	FTY-720A,FTY-720	S1P Receptor , PAK , LPL Receptor
	Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).		S1P Receptor , PAK , LPL Receptor
T1633	β-Carotene	Carotaben,Beta-Carotene,Provitamin A	Apoptosis , ROS , Endogenous Metabolite
	β-Carotene (Provitamin A) is a naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities. As an anti-oxidant, beta carotene...		Apoptosis , ROS , Endogenous Metabolite