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Results for "

naphthoquinone

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    34
    TargetMol | Inhibitors_Agonists
  • Natural Products
    17
    TargetMol | Natural_Products
  • Isotope Products
    1
    TargetMol | Isotope_Products
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    1
    TargetMol | Inhibitors_Agonists
1,4-Naphthoquinone
α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-Dione
T7048130-15-4
1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].
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Potassium 1,2-naphthoquinone-4-sulphonate
T2035215908-27-0
Potassium 1,2-naphthoquinone-4-sulphonate (Compound 16) acts as an inhibitor of 6-phosphogluconate dehydrogenase (6PGDH) with an IC50 of 53 μM. This compound is applicable in research related to human African trypanosomiasis.
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1,2-Naphthoquinone
NSC-9831, NSC9831, NSC 9831
T20410524-42-5
1,2-Naphthoquinone is an agent of fungicide.
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2-Amino-3-carboxy-1,4-naphthoquinone
TN1208173043-38-4
2-Amino-3-carboxy-1,4-naphthoquinone is an electron transfer mediator that can alter glucose metabolism in homofermentative lactic acid bacteria. It also serves as a novel growth stimulator for bifidobacteria, influencing their end-product profile through the mediated oxidation of NAD(P)H.
    7-10 days
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    2-Carbamoyl-3-hydroxy-1,4-naphthoquinone
    TN5790103646-20-4
    2-Carbamoyl-3-hydroxy-1,4-naphthoquinone is a natural product for research related to life sciences. The catalog number is TN5790 and the CAS number is 103646-20-4.
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    6-Methyl-1,4-naphthoquinone
    TXB-00204605-93-6
    6-Methyl-1,4-naphthoquinone is a reagent used in biochemical reactions.
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    2-Chloronaphthoquinone
    2-Chloro-1,4-naphthoquinone
    T70751010-60-2
    2-Chloronaphthoquinone (2-Chloro-1,4-naphthoquinone) is a substituted naphthoquinone which is used as an insecticide and acaricide.
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    Menadione
    Vitamin K3
    T044958-27-5
    Menadione (Vitamin K3) is a synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.
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    Quinoclamine
    T167062797-51-5
    Quinoclamine is a naphthoquinone derivative and is an NF-κB inhibitor.
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    Plumbagin
    Plumbagone, Plumbagine, Plumbaein, 2-Methyljuglone
    T2841481-42-5
    Plumbagin (Plumbaein) is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe.
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    Lawsone
    Hennotannic acid, 2-hydroxy-1,4-naphthoquinone
    T296983-72-7
    Lawsone (Hennotannic acid) (2-hydroxy-1,4-naphthoquinone), also known as hennotannic acid, is a red-orange dye present in the leaves of the henna plant (Lawsonia inermis) as well as in the flower of water hyacinth (Eichhornia crassipes).
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    2-Hydroxyanthraquinone
    T36914605-32-3
    2-Hydroxyanthraquinone is an anthraquinone that has been found inSpermacoce latifoliaand has antibacterial and estrogenic activities.1,2It is active againstB. subtilisandB. cereus(MICs = 1.9 and 62.5 μg ml, respectively).12-Hydroxyanthraquinone (19 μM) induces estrogen receptor α (ERα) activation in a yeast two-hybrid assay.2 1.Luo, Y., Shen, H.-Y., Shen, Q.-X., et al.A new anthraquinone and a new naphthoquinone from the whole plant of Spermacoce latifoliJ. Asian Nat. Prod. Res.19(9)869-876(2017) 2.Kurihara, R., Shiraishi, F., Tanaka, N., et al.Presence and estrogenicity of anthracene derivatives in coastal Japanese watersEnviron. Toxicol. Chem.24(8)1984-1993(2005)
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    4-6 weeks
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    Lawsone methyl ether
    2-Methoxy-1,4-naphthoquinone, 2-Methoxy-p-naphthoquinone, 2-Methoxynaphthoquinone
    T30082348-82-5
    Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) induces apoptosis in A549 cells independently of cell cycle arrest, mediated by JNK and p38 MAPK signaling pathways. These pathways are activated due to oxidative DNA damage from increased ROS generation in MNQ-treated A549 cells.
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    (-)-Alkannin
    Alkannin, Shikonin
    T4958517-88-4
    (-)-Alkannin (Shikonin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.
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    Naphthazarin
    DHNQ, 5,8-Dihydroxy-1,4-naphthoquinone
    T8678475-38-7
    Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. It triggers apoptosis and has anti-tumor effects
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    Antimalarial agent 14
    4-hydroxy-3-phenyl-naphthalene-1,2-dione, 2-Hydroxy-3-phenyl-1,4-naphthoquinone
    T223811150-59-0
    Antimalarial agent 14 (NSC-102533) is a bioactive chemical.
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    TargetMol | Inhibitor Sale
    FUT8-IN-1
    T204573
    FUT8-IN-1 (Compound 37) is an inhibitor of α-1,6-fucosyltransferase (FUT8), with a dissociation constant (KD) of 49 nM and an IC50 around 50 µM. In the presence of FUT8, FUT8-IN-1 forms a highly active naphthoquinone imine intermediate, thereby inhibiting FUT8's enzymatic activity.
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    A 80915A
    A80915A,A-80915A
    T26450127875-60-9
    A 80915A is A semi-naphthoquinone antibiotic from Streptomyces aculeolatus. It is a potent inhibitor of gastric (H(+)-K+)-ATPase. Inhibition by A80915A is dependent on the conformation of gastric (H(+)-K+)-ATPase, potassium slows the rate of inhibition by
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    (±)-Shikonin
    Anchusin, Anchusa acid, Alkanet extract, (±)-Shikonin
    T289754952-43-1
    (Rac)-Shikonin (Anchusin) is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used for the production of medicinals, cosmetics, and some food products; shikonin also enters into the antiinflammatory ointment and cream compositions used for the treatment of burns. It can suppress the cell viability, adhesion, invasion and migratory ability of MGC-803 cells through TLR2- or NF-κB-mediated pathway.
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    AK-135
    T2979275397-64-7
    AK-135 is a derivative of 1,4-naphthoquinone (Menadione). AK-135 has been shown to restore the electron flow in defective respiratory chain (hypoxia or rotenone) systems more effectively than Menadione.
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    Biflorin
    T3044989701-85-9
    Biflorin is an o-naphthoquinone of clinical significance.
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    Methylspinazarin
    T3620741768-12-1
    Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg kg. |1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gatechol-O-methyl transerfase inhibitors produced by Streptomyces. J. Antibiot. 26(2), 112-114 (1973).
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    CAY10763
    CAY10763
    T366452364458-49-9
    CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively). It reduces tumor growth in B16/F10 mouse melanoma and HepG2 mouse xenograft models when administered at doses of 100 and 10 mg/kg, respectively. 1.Huang, R., Jing, X., Huang, X., et al.Bifunctional naphthoquinone aromatic amide-oxime derivatives exert combined immunotherapeutic and antitumor effects through simultaneous targeting of indoleamine-2,3-dioxygenase and signal transducer and activator of transcription 3J. Med. Chem.63(4)1544-1563(2020)
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    Juglone
    Regianin, 5-Hydroxy-1,4-naphthoquinone
    T4010481-39-0
    Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis trans isomerases of the parvulin family, including human Pin1, yeast Ess1 Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 μM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms.
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