mr 1

HMR 1556 is a chromanol derivative and is an IKs blocker (IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively).

Anti-Mouse CD40L CD154 Antibody (MR-1) is an IgG antibody inhibitor derived from an American hamster, specifically targeting mouse CD40L CD154.

stimulates the release of acetylcholine from synaptosomes

Pyridoclax is an inhibitor of potential Mcl-1.

Resomelagon (AP1189) is a potent, orally active melanocortin receptor (MR) agonist that induces Ca2+ mobilization and ERK1 2 phosphorylation, demonstrating anti-inflammatory activity useful in obesity and chronic inflammation research [1] [2].

Plamotamab (XmAb-13676), a human bispecific antibody (bsAb) targeting CD3 and CD20, recruits cytotoxic T cells to eliminate CD20-expressing tumor cells. It demonstrates mild hematologic reaction (MR) and effectively induces tumor regression in vivo [1] [2].

MR 409, a selective growth hormone-releasing hormone (GHRH) agonist, exhibits notable neuroprotective properties by augmenting endogenous neurogenesis in cerebral ischemic mice and demonstrates the ability to inhibit in vivo lung cancer growth [1] [2] [3] [4].

MR-2-93-3, a long-chain fatty acid, functions as a carrier for polynucleotides [1].

MR-2088 is a selective inhibitor of ULK1 and ULK2, with pEC50 values of 8.3 and 8.7, respectively. It effectively inhibits autophagy by targeting ULK1 2-mediated pathways [1].