homologue — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6357	(S)-crizotinib	ent-crizotinib	Apoptosis , DNA/RNA Synthesis , MTH1
	(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.		Apoptosis , DNA/RNA Synthesis , MTH1
T8103	H-HoArg-OH		Endogenous Metabolite , Phosphorylase
	H-HoArg-OH, a homologue arginine, is a strong inhibitor of human liver and bone alkaline phosphatase.		Endogenous Metabolite , Phosphorylase
T0369	Ethaverine hydrochloride	Consenil,Ethaquin,Papetherine	MAO
	Ethaverine hydrochloride (Ethaquin) is a homologue of papaverine.		MAO
T1366	3-Pyridylacetic acid hydrochloride		DPP-4
	3-Pyridylacetic acid hydrochloride (3-PAA-HCl) is a high homologue of niacin. It is a decomposition product of nicotine (and other tobacco alkaloids). It can also react with amines, alcohols and carboxylic acids, and can...		DPP-4
T8100	Azetidine-2-carboxylic acid		Others
	Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including hu...		Others
T67929	Linoleoyl glycine
	Linoleoyl glycine, a modified polyunsaturated fatty acid, is an endogenous homologue of linoleoyl glycine. Linoleoyl glycine activates human KCNQ1/KCNE1 (hKCNQ1/hKCNE1) channels expressed in xenopus oocytes from mammalia...
T70163	Bizine dihydrochloride
	Bizine dihydrochloride is a potent LSD1 inhibitor in vitro, being selective versus monoamine oxidases A/B and the LSD1 homologue, LSD2.
T38685	C12-Sphingosine	C12-Sphingosine
	C12-Sphingosine is a short-chain homologue of Sphingosine. It effectively inhibits the activity of serine palmitoyltransferase in primary cultured cerebellar cells.
T19188	ALLO-1		Autophagy
	ALLO-1 is a crucial autophagy receptor responsible for facilitating the formation of autophagosomes around paternal organelles. It directly interacts with the worm LC3 homologue, LGG-1, through its LC3-interacting region...		Autophagy
T69376	Viriditoxin
	Viriditoxin is a secondary metabolite isolated from Aspergillus viridinutans that has been shown to inhibit FtsZ, the bacterial homologue of eukaryotic tubulin.
T81743	MTORC1-IN-1		mTOR
	mTORC1-IN-1 (T1), a rapamycin homologue (rapalog) and selective inhibitor of mTORC1, controls cell growth and metabolism, with implications in various diseases such as cancer. It interacts with mTORC1 by attaching to the...		mTOR
T79730	LB244		STING
	LB244, a homologue of BB-Cl-amidine, functions as an orally effective STING inhibitor with an EC50 value of 0.8 μM, applicable in the treatment of STING-dependent inflammatory diseases. However, pharmacokinetic studies h...		STING
T83531	(Rac)-Juvenile hormone III
	(Rac)-Juvenile hormone III, derived from farnesoic acid, represents the most prevalent homologue of juvenile hormones [1].
T82613	Danburstotug	STI-3031,IMC-001	PD-1/PD-L1
	Danburstotug (IMC-001), an immunostimulant and antineoplastic [1], is a humanized IgG1-lambda monoclonal antibody targeting CD274 (PDL1, B7 homologue 1, B7H1).		PD-1/PD-L1
T36649	AN3661
	AN3661, a potent antimalarial lead compound, targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue subunit 3 (PfCPSF3). AN3661 inhibits Plasmodium falciparum laboratory-adapted strains...
T36798L	SW2_110A acetate		Histone Methyltransferase
	SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate has a high affinity for CBX8N, inhibits the association bet...		Histone Methyltransferase