hle

Michler's ketone, with CAS No. 90-94-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Michler's ketone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Cochlearine is a useful organic compound for research related to life sciences and the catalog number is T124717.

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is similar to Bleomycin which binds and intercalates DNA to damage the integrity of the double helix.

Phlebiakauranol aldehyde is an antifungal and cytotoxic metabolite.

Lycophlegmarine is a bioactive chemical.

Lycophlegmine is a bioactive chemical.

Phleomycin D1 (PLM D1), a glycopeptide antibiotic in the Bleomycin/Phleomycin family, induces cell death by binding to and cleaving DNA [1] [2] [3].

Cochleamycin A exhibits strong inhibitory activity against tumor cells, with IC50 values (μg/mL) of 1.6, 14.0, 6.2, 16.5, and 19.1 for P388, HL60, K562, COL0205, and HT29 cells, respectively. Additionally, Cochleamycin A possesses activity against Gram-positive bacteria.

Phleomycin E is a peptide-based antibiotic that is effective against Gram-positive and Gram-negative bacteria as well as mycobacteria. It extends the survival time of mice with transplanted Ehrlich ascites carcinoma and shows inhibitory effects on murine pulmonary solid tumors, with an IC50 of 0.31 μg/mL.

4-Hydroxyphlebiarubrone is a quinone antibiotic. It exhibits weaker resistance against Gram-negative bacteria and possesses cytotoxic properties.

Eichlerialactone and ethyl eichlerianoate show antimycobacterial activity against mycobacterium tuberculosis H37Ra, with minimum inhibitory concentration in the range of 25-50ug/mL; eichlerialactone exhibits good antibacterial activity against both the Gr

Eichlerianic acid is a trypanocidal compound with an IC50 value of 10 mg mL. Eichlerianic acid may have antiviral activity against Herpes simplex virus types I and II in vitro. Eichlerianic acid shows weak cytotoxicity (IC50 6.87 to >40 μM) against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480).

Methyl eichlerianate is a natural product of Aglaia, Meliaceae. The catalog number is TN4543 and the CAS number is 56421-12-6. Methyl eichlerianate can be used as a reference standard.

Phlegmanol C is a natural product for research related to life sciences. The catalog number is TN4763 and the CAS number is 1260-05-5.

Schleicheol 1 has antitumor activity, it possesses inhibitory activity against SGC-7901 cell line.

Schleicheol 2 is a natural product of Helianthus, Asteraceae. The catalog number is TN4961 and the CAS number is 256445-68-8. Schleicheol 2 can be used as a reference standard.

Thiomichler's ketone (4,4'-Bis(dimethylamino)thiobenzophenone) is a photometric reagent suitable for detecting gold, palladium, platinum, mercury, silver, and copper. Additionally, it serves as a biomaterial or organic compound used in life sciences research.

DMP 777 is an orally active inhibitor of human leukocyte elastase.

L 708286 is an agent of peptide-based phenethylcarbamoyldifluoromethylene. It is a slow-binding inhibitor of human leucocyte elastase (HLE).

Gresonitamab (AMG 910), a half-life extended (HLE) bispecific T-cell engager (BiTE) antibody, specifically targets CD3-positive T cells and CLDN18.2-expressing tumor cells, offering potential research applications in adenocarcinoma [1].

Tarlatamab (AMG-757) is a first-in-class, high-affinity bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3), a protein primarily expressed in small-cell lung cancer (SCLC) with minimal expression in normal tissues. It has dissociation constants (KDs) of 0.64 nM and 0.50 nM for DLL3 in human and nonhuman primates (NHP), respectively, and 14.9 nM and 12 nM for CD3 in human and NHP, accordingly. As a pioneering HLE BiTE immuno-oncology therapy for DLL3-expression SCLC, tarlatamab shows promising potential for research in this area [1].

Ophiopogonin R (compound 3), a steroid saponin, was isolated and purified from natural ophiopogonin and demonstrated no cytotoxicity against five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403, and Hela) [1].

Acapatamab (AMG-160) is a Half-Life Extended (HLE) Bispecific T-cell Engager (BiTE) with domains that bind to PSMA and CD3. It exhibits Kd values of 14.8 nM for hPSMA and 22.4 nM for hCD3. This compound is utilized in cancer research.