enterovirus

Fluticasone propionate (CCI-187881), derived from fluticasone used to remedy asthma and allergic rhinitis, is a high affinity, selective GR (glucocorticoid receptor) agonist.

EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity that inhibits the replication of severe acute respiratory syndrome coronavirus [SARS-CoV] in Vero 76 cells, Middle East respiratory syndrome coronavirus [MERS-CoV] in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s = 0.1, 0.15, and 0.3 μM, respectively).

Pirodavir (R77975) (R 77975), the prototype of broad-spectrum anti-picornavirus compounds, is a potent human rhinovirus (HRV) capsid-binding inhibitor.

LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.

Pocapavir (SCH-48973) is an investigational enterovirus (EV) capsid inhibitor.

Vapendavir diphosphate (BTA798 diphosphate) is a rhinoceros/enterovirus inhibitor that targets the hydrophobic pocket in the viral capsid and is a capsid-binding agent with antiviral activity that prevents viral entry into the cell. Vapendavir diphosphate inhibits EV71 replication.

Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally or by the intravenous route.

PD 169316 is a potent, cell-permeable, and selective inhibitor of p38 MAP kinase.

Hederasaponin B (Hederacoside B) has antiviral activity, via inhibiting the viral VP2 protein expression and blocking viral capsid protein synthesis.

(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A, used in the synthesis of Golgicide A.

Pleconaril (VP 63843) is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).

MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.

1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation. 3. Corydaline exhibits the anti-acetylcholinesterase, antiallergic, and antinociceptive activities. 4. Corydaline has potent inhibition of CYP2C19 and CYP2C9.

Golgicide A is a potent and rapidly reversible GBF1 inhibitor.

Norwogonin (5,7,8-Trihydroxyflavone), isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (IC50: 31.83 μg/ml).

Prunin (Naringenin 7-0-glucoside) possesses anti-diabetic, and anti-abacterial properties, it can inhibit protein tyrosine phosphatase 1B (PTP1B) and stimulate glucose uptake in insulin-resistant HepG2 cells; it also can stimulate growth of Pseudomonas aeruginosa and different Bacilllus sp. Prunin exhibits a markedly enhanced solubility compared to naringenin and naringin while maintaining the in vitro inhibition of HMG-CoA reductase.

Anti-Enterovirus 71 VP4 Antibody (3E202) is a monoclonal antibody targeting EV71 (Enterovirus 71) VP4, which is a mouse-derived antibody.

EV-A71-IN-3 (Compound IRE-03-3) is an inhibitor of the enterovirus A71 (EV-A71). It targets the internal ribosome entry site (IRES) of EV-A71, blocking IRES-mediated translation and thereby preventing viral proliferation, with an EC50 of 11.96 μM.

HR-568 displays broad-spectrum anti-enterovirus activity. It inhibits enterovirus strains EV-A71, E30, and CVA24 in MRC-5 cells, with EC50 values of 1.53 μM, 0.4 μM, and 1.22 μM, respectively. HR-568 targets the hydrophobic pocket on enterovirus capsid proteins, thereby hindering viral replication.

Dyrk1A-IN-12 (compound S43) is an inhibitor of dual specificity tyrosine phosphorylation regulated kinase 1A (Dyrk1A). It has an IC50 of 95 nM for inhibiting Dyrk1A. The compound demonstrates antiviral activity against EV-A71 (Enterovirus A71) with an EC50 of 4.4 μM, a CC50 of 12.8 μM, and a selectivity index (SI) of 2.9. Additionally, Dyrk1A-IN-12 exhibits potent inhibitory effects on the herpes simplex virus (HSV).

MDL-860 is a broad-spectrum antiviral compound targeting small RNA viruses and exhibits low cytotoxicity to human cells. MDL-860 is useful for research into viral infections.

CoxB-IN-1 (7a) exhibits antiviral activity against Coxsackie B virus (CoxB). This compound demonstrates dual functionality by inhibiting both virus adsorption and replication. Additionally, CoxB-IN-1 (7a) shows significant potential as an inhibitor of the Coxsackie virus 3C protease.

Antiviralagent 71 (Compound 26) is a potent antiviral agent exhibiting broad-spectrum activity against enteroviruses such as EV-D68, Echo-11, and HRV-14, with an EC50 ranging from 0.017 to 4.1 μM. Antiviralagent 71 is utilized in research related to non-polio enterovirus (NPEV) infections.

MDL-20610 is a potent antirhinovirus compound with a plaque-reduction half-maximal inhibitory concentration (IC1/2) of 0.003 µg/mL. It also shows activity against human, simian, and bovine rotaviruses, as well as varying activity against enterovirus and paramyxoviruses. MDL-20610 is applicable in antiviral research.