ebv

EBV lytic cycle inducer-1 is an iron chelate analogue that induces the lytic cycle of EBV.

EBV activator C60 is an EBV activator, and a well-performing EBV lytic cycle inducer.

CEF14, EBV Rta Protein (28-37), is the HLA A24-restricted epitope from the Epstein-Barr virus Rta Protein (28-37).

Penciclovir (BRL 39123) is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.

Endoxifen, also known as N-desmethyl-4-hydroxytamoxifen, is a chemical that is under development for estrogen receptor-positive breast cancer. It is also being evaluated as an antipsychotic for treatment of mania and other psychotic disorders. Endoxifen is a nonsteroidal selective estrogen receptor modulator (SERM) of the triphenylethylene group. It is an active metabolite of tamoxifen and has been found to be effective in patients that have failed previous hormonal therapies (tamoxifen, aromatase inhibitors, and fulvestrant). The prodrug tamoxifen is metabolized by the CYP2D6 enzyme to produce afimoxifene (4-hydroxytamoxifen) and endoxifen.

3,29-O-Dibenzoyloxykarounidiol is a natural product with regulate blood sugar level, has potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA).

EBVBZLF1 (190-197) TFA is an immunodominant CEF control peptide derived from the Epstein-Barr virus (EBV). It serves as an optimal epitope for CD8+ T cells, facilitating the release of IFNg. The CD8 positive cytotoxic T lymphocyte (CTL) response elicited by EBVBZLF1 (190-197) TFA is diverse and capable of cross-recognizing similar peptide segments from both host proteins and bacterial proteins. This compound is useful for research in autoimmune diseases.

20-Hydroxylucidenic acid E2 is a triterpene compound identified in Ganoderma ludicum. It significantly inhibits TPA-induced inflammation and suppresses TPA-induced EBV early antigen expression with an IC50 of 290 mol ratio/32 pmol TPA [indicating that the molar concentration of this compound is 290 times that of TPA (32 pmol) to achieve 50% inhibition of EBV early antigen expression]. This compound is applicable in anti-inflammatory and anticancer research.

Porritoxin (compound1) is a metabolite of Alternaria porri. It inhibits the activation of the Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA).

Lobucavir (BMS-180194; SQ 34514) is a nucleoside analogue and an antiviral agent with broad-spectrum activity against various viruses, including HBV, HIV/AIDS, and α, β, and γ herpesviruses (including CMV, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus).

EBVBZLF1 (190-197) is an immunodominant CEF control peptide derived from the Epstein-Barr virus (EBV). It serves as a suitable epitope for CD8+ T cells, facilitating the release of IFNg. The CD8 positive cytotoxic T lymphocytes (CTL) response to EBVBZLF1 (190-197) is diverse, capable of cross-recognizing similar peptide sequences from both host self-proteins and bacterial proteins. This peptide is also utilized in research on autoimmune diseases.

HLA-B*0801-bindingEBV peptide, derived from the Epstein-Barr virus (EBV) epitope FLRGRAYGL, interacts with the HLA-B*0801 molecule. This peptide is presented to CD8+ T cells via HLA-B*0801, thereby activating a specific immune response.

EBVEBNA3B (416-424) is an HLA-A11-restricted antigenic peptide derived from the EBVEBNA3B protein.

1. Dehydroabietic acid (Dehydroabietate) (DAA) is an EBV-EA activation inhibitor. 2. DAA is a useful food-derived compound for treating obesity-related diseases, by decreasing plasma glucose, insulin levels, plasma triglyceride (TG) , and hepatic TG levels. 3. DAA derivatives displays anti-secretory and anti-pepsin effect in animal models.

L2P4 is a peptide-based fluorescent probe targeting EBNA1 that inhibits the homodimerization of EBNA1 and selectively suppresses the growth of EBV+ tumors. Exhibiting cytotoxicity in EBV-positive C666-1 cells, L2P4 has an LC50 of 46.4 μM.

Emodin (Frangula emodin) is an 11β-HSD1 inhibitor with a selective IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice, respectively. Emodin has antiviral, anti-inflammatory, and anti-cancer effects. Emodin can improve metabolic disorders in diet-induced obese mice.

Biotin (Vitamin H) is a water-soluble B-vitamin and is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids.

LDC4297 hydrochloride is a selective and efficient CDK7 inhibitor with broad-spectrum antiviral activity. It inhibits herpesvirus, adenovirus, poxvirus, retrovirus, and positive-strand RNA viruses. It can be used for research on viral infections.

Tenofovir hydrate (GS 1278 hydrate) is a nucleotide reverse transcriptase inhibitor with antiviral activity, inhibits EBV replication, and is used in the study of HIV and HBV.

11-Oxomogroside IIa is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. It has inhibitory effects against the EBV-EA activation induced by TPA, shows weak inhibitory effects on activation of NOR 1, a nitric oxide (NO) donor.

BRL44385 is an effective and selective inhibitor of the replication of HSV-1 and HSV2, Epstein-Barr virus (EBV), and varicella-zoster virus (VZV).

Lipid C2 is an ionizable cationic lipid utilized in the formation of lipid nanoparticles (LNP) for the delivery of mRNA in vivo. LNPs containing Lipid C2 and encapsulating mRNA reporter genes specifically accumulate in the liver and spleen of mice, while avoiding the heart, lungs, and kidneys. Additionally, LNPs with Lipid C2 that encapsulate mRNA encoding Epstein-Barr virus (EBV) protein Latent Membrane Protein 2 (LMP-2), when combined with anti-programmed cell death protein 1 (PD-1) antibodies, have been shown to reduce tumor size, reverse T cell exhaustion, increase the percentage of CD3+CD8+ central T cells and CD3+CD8+ effector memory T cells in the spleen, and decrease the percentage of CD3+T cells expressing Pd-1 in a CT26 mouse model of EBV-infected colon cancer.

DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.

BLL5 Maleate is a first-in-class selective PRMT5 inhibitor, it blocks EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected.