dsg

1,2-Distearoyl-sn-glycerol is an internal standard for the isolation and characterization of molecular species of 1,2-diacyl-sn-glycerol (DAG).

DSG-D4 Deuterated Crosslinker is[Succinimidyl] 2,2,4,4-glutarate-D4 is a protein crosslinker that is permeable to cell membranes.

DSG-PEG (MW 2000) is a polyethylene glycol-conjugated lipid (PEG-lipid) primarily used as a key excipient in the preparation of lipid nanoparticles (LNPs) and liposomes. Its distearoyl glycerol anchor provides robust membrane anchoring within lipid bilayers. In nucleic acid delivery systems, DSG-PEG (MW 2000) modulates particle size, circulation stability, and cellular interaction kinetics, serving as a critical component for optimizing mRNA delivery efficiency and tissue targeting.

DSG-pSar25 is a liposome conjugated with DSG and the pSar25 polymer. It is applicable in the preparation of lipid nanoparticles for drug delivery.

DSG-pSar25-Maleimide is a lipid formed by the conjugation of DSG units with the pSar25 polymer. It is suitable for the preparation of lipid nanoparticles used in drug delivery.

DSG Crosslinker, a cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).

Anti-DSG3 Antibody is a highly specialized monoclonal antibody target the human desmoglein 3 protein, a critical cadherin-type cell adhesion molecule, inhibition of intercellular junctions between keratinocytes across various preclinical experimental models to modulate epithelial integrity and study the pathophysiology of pemphigus vulgaris.

LQVTDSGLYRCVIYHPP (LP17) is a peptide and TREM-1 (Triggering Receptor Expressed on Myeloid cells 1) inhibitor derived from a highly conserved sequence between the extracellular structural domains of mouse and human TREM-1 and TLT-1.LP17 inhibits TREM-1 activation through a decoy receptor LP17 inhibits TREM-1 activation by actin through a decoy receptor mechanism, which has the advantage of penetrating the brain barrier and attenuating neuronal damage and inflammatory responses.

LQVTDSGLYRCVIYHPP (LP17) TFA is a TREM-1 (triggering receptor expressed on myeloid cells) inhibitory peptide that significantly reduces ischemic infarction and neuronal damage, with the ability to penetrate the brain to inhibit TREM-1 [1].

BAY-524 belongs to small molecule inhibitors and is a Bub1 kinase inhibitor (IC50 = 450 nM under 2 mM ATP conditions) with good cell permeability and selectivity. This compound demonstrates antitumor potential and can be used in research on combination anticancer therapy.

LNSMGQD is a peptide that targets the adhesive interfaces of desmoglein (DSG1 and DSG3) core glycoproteins, interfering with the single peptide (SP) components of DSG trans-interactions. By binding to DSGs, LNSMGQD prevents the loss of DSG trans-interactions induced by autoantibodies, inhibits the activation of p38 MAPK, and prevents keratin filament retraction. It is useful for research into autoimmune skin diseases such as pemphigus vulgaris.