dengue-virus

Cyclofenil is an estrogen antagonist, has anti-dengue-virus activity

Lactimidomycin, isolated from Streptomyces, is an inhibitor of eukaryotic translation elongation. It is also a potent and non-toxic inhibitor of dengue virus 2 and other RNA viruses. Lactimidomycin has an antiproliferative effect on tumor cell lines. It i

The Anti-West Nile/dengue virus E protein Antibody (E60) is a mouse-derived IgG2akappa antibody targeting the West Nile/dengue virus E protein. Its isotype control is MouseIgG2akappa, Isotype Control.

Anti-Dengue virus type 2 E protein DIII Antibody (DV2-96) is an antibody targeting Dengue virus type 2 E protein DIII and can be used for infectious disease research.

Anti-Dengue virus type 4 E protein DIII Antibody (DV4-E88) is an antibody targeting Dengue virus type 4 E protein DIII and can be used for infectious disease research.

ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease.

QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK. The IC50 values of QL-X-138 are 9.4 nM for BTK, 107.4 nM for MNK1, 26 nM for MNK2, and 3.5 μM against Dengue 2. QL-X-138 is used in the study of B-cell malignancies and B-cell malignant tumors.

QL-X-138 HCl is a novel selective and highly potent BTK/MNK dual-kinase inhibitor with anticancer activity that binds covalently to BTK and noncovalently to MNK. QL-X-138 HCl inhibited BTK, MNK1, and MNK2 kinases. QL-X-138 HCl has anti-dengue virus 2 activity and shows anti-proliferative activity in acute myeloid leukemia cells. QL-X-138 HCl can be used to study lymphoma and leukemia.

Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.

(-)-JNJ-A07 is a selective and potent dengue virus (DENV) inhibitor with an EC50 of 31 nM, exhibiting significant antiviral activity for the study of dengue virus infections.

(+)-JNJ-A07 is a pan-serotypic dengue virus inhibitor that targets NS3-NS4B interaction with high potency. (+)-JNJ-A07 has antiviral activity and can be used to study dengue virus infections.

Antiviral Agent 51 (compound A) is a fucoidan and antiviral agent that inhibits Human alphaherpesvirus 1 and interacts with the RNA-dependent RNA polymerase (RdRp) of DENV-2, making it useful for studying dengue virus.

Melianone exhibits antiviral activity (EC50s: 3-11μM) against three important human pathogens, belonging to the Flaviviridae family, West Nile virus, Dengue virus, and Yellow Fever virus.

KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene), an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has antiviral activity against RNA viruses, HCV, and RSV.

SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.

FGI-106 is a potent, broad-spectrum inhibitor demonstrating activity against various viruses, including Ebola, Rift Valley Fever, and Dengue Fever, exhibiting EC50 values of 100 nM, 800 nM, and 400-900 nM, respectively. Furthermore, it effectively inhibits non-hemorrhagic fever viruses such as HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively.

FGI-106 tetrahydrochloride demonstrates potent inhibitory activity across a broad spectrum of viruses, including those causing hemorrhagic fevers such as Ebola, Rift Valley, and Dengue Fever, with half-maximal effective concentrations (EC50s) of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, it effectively inhibits non-hemorrhagic fever viruses, notably HCV and HIV-1, with EC50s of 200 nM and 150 nM, respectively, indicating its broad-spectrum antiviral potential.

Tin-protoporphyrin IX dichloride (SnPPIX dichloride) is an HO-1) inhibitor with antiviral activity that inhibits dengue and yellow fever viruses.

IHVR-19029 is an effective endoplasmic reticulum (ER) α-glucosidases I and II inhibitor (IC50: 0.48 μM for ER a-glucosidase I). IHVR-19029 efficiently blocks the replication of several hemorrhagic fever viruses, such as Ebola virus, Dengue virus, and Rift

NITD008 (7-Deaza-2'-C-acetylene-adenosine) is a potent and selective adenosine nucleoside inhibitor.NITD008 is an adenosine nucleoside analog with broad-spectrum antiviral activity that inhibits dengue, animal cupripoxvirus, and Zika virus.

QL47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other RNA viruses.QL47 acts as an inhibitor of viral translation and a covalent inhibitor of BTK, and can be used in the study of lymphomas.

U18666A is a cell-permeable drug and is a cholesterol synthesis and transport inhibitor. It inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.

Narasin is a polyether ionophore antibiotic with established antimicrobial activity and reported potential antiviral and anticancer effects in experimental studies. Narasin has been shown to inhibit NF-κB signaling and induce apoptosis in tumor cells, and may suppress tumor metastasis and the growth of ERα-positive breast cancer cells by modulating TGF-β/SMAD3 and IL-6/STAT3 signaling pathways

Ac-EVKKQR-pNA is a competitive chromogenic substrate targeting the P6-P1 segment at the NS2B-NS3 cleavage site's N-terminal, featuring a highly reactive, hydrolyzable para-nitroaniline (pNA) at the P1 position. This compound holds promise for research into Dengue virus type 2 and Yellow fever virus infections.