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IRBM-Z-1
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Catalog No. T218832 Copy Product Info
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IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease with an IC50 of 1.8 μM. It also inhibits the mutated Dengue virus type 2 (DENV2) and West Nile virus (WNV) NS2B-NS3 proteases, exhibiting IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 effectively inhibits Zika virus replication and reduces virus-induced cytopathic effects, making it useful for research related to ZIKV infection.
IRBM-Z-1
Cas No. 67629-86-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | IRBM-Z-1 is a non-competitive inhibitor of Zika virus (ZIKV) NS2B-NS3 protease with an IC50 of 1.8 μM. It also inhibits the mutated Dengue virus type 2 (DENV2) and West Nile virus (WNV) NS2B-NS3 proteases, exhibiting IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 effectively inhibits Zika virus replication and reduces virus-induced cytopathic effects, making it useful for research related to ZIKV infection. |
| In vitro | IRBM-Z-1 inhibits the replication of stable ZIKV replicons in Vero cells after 72 hours, with an EC 50 of 6.0 μM, and shows no cytotoxicity at concentrations up to 32 μM. Additionally, IRBM-Z-1 suppresses ZIKV-induced cytopathic effects in Vero cells over 6 days, with an EC 50 of 6.25 μM. |
| Molecular Weight | 390.36 |
| Formula | C19H17F3N4O2 |
| Cas No. | 67629-86-1 |
| Smiles | O=C([N-]C=1ON=[N+](C1)C(C)CC=2C=CC=CC2)NC3=CC=CC(=C3)C(F)(F)F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: IRBM-Z-1 in vitro | IRBM-Z-1 formula | IRBM-Z-1 molecular weight
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