c48

NSC368262 is a selective Stat3-family member inhibitor. NSC368262 alkylates Cys468 in Stat3.

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde produced via a condensation reaction. It acts as a mast cell degranulator and histamine releaser and inhibits phosphatidylinositol-specific phospholipase C activity in human platelets.

EOP (t18:0/30:0/18:2) (C48:2 EOP (t18:0/30:0w18:2 (9Z,12Z)); N-(30-Linoleoyloxy-triacontanoyl)-phytosphingosine) is a phytoceramide-based compound resembling EOS. This compound is synthesized by esterifying ω-hydroxy very long-chain ceramides (C28-36) with the essential fatty acid linoleic acid. EOP (t18:0/30:0/18:2) has been utilized as a component in models of stratum corneum lipid mixtures.

EOS (d18:1/30:0/18:2) is a lipid molecule that can be used in life science related research. The CAS number of EOS (d18:1/30:0/18:2) is 97040-38-5.

The Anti-MUC1/CD227 Antibody (C595 (NCRC48)) is a chimeric mouse IgG3, κ antibody targeting human MUC1/CD227. Its isotype control is the Mouse IgG3 kappa, Isotype Control.

Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) and a HER2-targeted cytotoxic agent, consisting of an anti-HER2 monoclonal antibody conjugated to MMAE via a cleavable linker, used for the treatment of HER2-expressing solid tumors including gastric cancer, breast cancer, and urothelial carcinoma.

Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors. [1] Osunprotafib (ABBV-CLS-484) stimulates the tumor microenvironment and promotes natural killer cell and CD8 T cell function and enhances T cell anti-tumor immunity by enhancing JAK-STAT signaling and reducing T cell dysfunction. [2]

NSC 4810 is an amide bioactive compound that has been used as a substrate for cytochrome P450 enzymes in vivo and as a substrate for acetylcholinesterase in vitro.

ML241 is a potent and selective inhibitors of p97 ATPase.ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the chemotherapy of cancer, and provide a rationale for developing pathway-specific p97 inhibitors.

BTK-IN-16 is a potential inhibitor of wild-type BTK and C481S mutants.BTK-IN-16 can be used to study various autoimmune diseases and cancers caused by BTK.

N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor, a BTK ligand, inhibits WT BTK and C481S BTK, which can be used to synthesize a range of PROTAC molecules.N-piperidine Ibrutinib hydrochloride has potential anticancer N-piperidine Ibrutinib hydrochloride has potential anticancer activity, inhibiting the growth and proliferation of cancer cells.

SPR719 is an inhibitor of gyrase B, has bactericidal activity.

ARQ-531 is a potent and orally active BTK inhibitor with potential antineoplastic activity, with IC50s of 0.85 nM and 0.39 nM for WT-BTK and C481S-BTK, respectively.

NMS-873 is a potent and selective allosteric inhibitor of VCP/p97.

SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.

DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.

N-Butyl stearate (NSC-4820，Stearic acid butyl ester) is an oily organic reagent that is an excellent PVC internal lubricant for organic synthesis.

UAMC-4821 is a ferroptosis inhibitor with an IC50 of 5.2 nM. It effectively scavenges free radicals, inhibits lipid peroxidation, and prevents ML162-induced ferroptosis, providing protective effects on HT-1080 cells. With favorable pharmacokinetic properties in mice, UAMC-4821 presents an oral bioavailability of 63% and demonstrates blood-brain barrier permeability.

BMS-599626 (AC480) has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.

BMS-599626 2HCL (AC480 2HCl) is a BMS-599626 derivative. BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respectively. BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor BMS-599626 inhibits tumor cell proliferation and has the potential to increase tumor response to radiotherapy.

Ethimidine is an antineoplastic.

AC 485 is a biochemical.

IMC-48, as a BCL2 i-motif-interactive compound, can act by stabilizing or facilitating the folding of the i-motif.

SC-48274 is a novel anxiolytic. SC-48274 has anxiolytic activity of the same potency as buspirone and repeated-dose administration is needed to induce anxiolytic acitivity.