amaryllidaceae

Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.

1-PeCSO is isolated from onion or garlic bulbs. It acts as a key compound in garlic greening and reacts with lachrymatory factor synthase.

S-Allylmercaptocysteine (SAMC) is an organic sulfur compound extracted from garlic, with anti-cancer, anti-inflammatory, and antioxidant properties. It protects against hepatocellular damage, improves alcoholic liver disease by modulating insulin receptor signaling, and enhances anti-tumor immunity by inhibiting PD-L1 expression.

Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors.

S-allyl-L-cysteine (S-Allylcysteine), a natural constituent of fresh garlic, has antioxidant and anticancer properties in animals.

Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth muscle cells' proliferation and migration induced by insulin, which may be related to the inhibition of the activation of ERK signal path. Allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats, it may beneficially affect two risk factors for atherosclerosis-hyperlipidemia and hypertension.

orcinol (5-Methylresorcin) is anxiolytic agent without sedative effect.

2,6-Dimethoxybenzoic acid is an o-methoxybenzoic acid and its derivatives that inhibit fungi and bacteria.

Diallyl disulfide has antitumor effect, the effect can be enhanced by miR-200b and miR-22.

Ethyl hydrocinnamate is an aromatic compound bearing an ester group, exhibiting inhibitory activity against chymotrypsin and suitable for biochemical experiments and drug synthesis research.

S-Allylmercaptocysteine HCl is an organosulfur compound isolated from aged garlic with anti-inflammatory, antioxidant, anticancer, and antitumor activities.S-Allylmercaptocysteine HCl inhibits inflammation in COPD and targets Nrf2 in osteoarthritis therapy through the NOX4/NF-kappaB pathway. Targeting Nrf2.

Spirostan-3-ol (Sarsaponin) is a stereoisomer of Sarsasapogenin (S142505), a steroid glycoside isolated from plant materials. A saponin with with potential anti-tumor activity via apoptosis.

Haemanthamine is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiviral, antioxidant, and anticonvulsa

γ-Glutamyl-S-1-propenyl cysteine is a compound obtained from garlic with strong free radical scavenging activity.

Orcinol glucoside (Sakakin) (OG), an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn, shows potent antioxidative and anxiolytic activities without sedative effects.

Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.

Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph

1. Lycobetaine (Ungeremine) is a potential biofungicide against Penicillium roqueforti and Aspergillus niger.2. Lycobetaine have strong antibacterial activity against Flavobacterium columnare . 3. Lycobetaine effectively targets mammalian as well as bacterial type I and type II topoisomerases.4. Lycobetaine shows strong acetylcholinesterase inhibitory activity(IC(50) value of 0.35 microM). 5. Lycobetaine has antiprotozoal activity, it shows good activity in in vitro assays against Trypanosoma brucei rhodesiense, T. cruzi.

S-Allylmercapturic Acid (N-Acetyl-S-allyl-L-cysteine) is a metabolite of S-allyl-L-cysteine present in black garlic with potential anti-gout effects, inhibiting both CYP2D6 and CYP-catalyzed reactions.

Allitol (d-allitol) is a substrate for the production of L-form ketoses and aldoses.

1. Gitogenin, tigogenin, and solasodine are novel selective inhibitors of UGT1A4, and do not inhibit the activities of major human CYP isoforms. 2. Gitogenin and (25S)-5α-furastan-3β, 22, 26-triol are the inhibitors of enzyme α-glucosidase with IC50 value

1. Dihydrolycorine-HCL(DL) shows hypotensive effects, it can block alpha 1-adrenoceptors. 2. Dihydrolycorine is an inhibitors of protein synthesis in eukarytic cells, it halts protein synthesis in eukaryotic cells by inhibiting the peptide bone formation

Galanthamine (Galantamine) is an acetylcholinesterase (AChE)inhibitor(IC50 : 500 nM), can reduce brain damage induced by hypoxia-ischemia.

Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.