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a375

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  • Inhibitors & Agonists
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protac braf-v600e degrader-1
Compound 23
T87452417296-84-3
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.
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PROTAC MEK1 Degrader-1
T791442671004-41-2
PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1 2 phosphorylation. With a pIC50 value of 7.0, it exhibits antiproliferative activity against A375 cells [1].
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KL-465
T200748
KL-465, a MAGE-A3 PROTAC degrader, effectively degrades MAGE-A3 in HeLa cells with a DC50 of 2 μM. It also inhibits the proliferation of MAGE-A3-positive cancer cells, specifically in HCT116, A375, and HeLa cell lines.
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PROTAC SMARCA2 degrader-8
T893252669027-50-1
PROTACSMARCA2 degrader-8 (compound 1) is an effective SMARCA2 degrader, exhibiting a DC50 of 28nM in A375 cells.
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