pma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0198	Phorbol 12-myristate 13-acetate	PMA	NF-κB , S1P Receptor , PKC
	Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13-acetate induces THP1 cell differentiation.		NF-κB , S1P Receptor , PKC
T8825	Capmatinib 2HCl.H2O	INCB28060 2HCl.H2O,INC-280 2HCl.H2O,NVP-INC280 2HCl.H2O	c-Met/HGFR
	Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.		c-Met/HGFR
T8416	Capmatinib xHCl	INCB28060,Capmatinib hydrochloride(free base),INC280	c-Met/HGFR
	Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activit...		c-Met/HGFR
T1963	Capmatinib	NVP-INC280,INC-280,INCB28060	Apoptosis , c-Met/HGFR
	Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.		Apoptosis , c-Met/HGFR
T4260	Capmatinib 2HCl	INC-280 2HCl,INCB28060 2HCl	c-Met/HGFR
	Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-...		c-Met/HGFR
TF0084	PMAL-C12

T80259	PMAP-23
	PMAP-23 is an antimicrobial peptide (AMP) with biological activity, derived from porcine myeloid cells.
T80394	Des(8-14)brevinin-1PMa
	Des(8-14)brevinin-1PMa is a host-defense peptide known for its potent antimicrobial properties, particularly against Staphylococcus aureus and Echerichia coli. Additionally, this compound demonstrates hemolytic activity ...
TF0040	PMAL-C8

TF0041	PMAL-C16

T14488	Azt-pmap		HIV Protease
	AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1]. As a nucleoside reverse transcriptase inhibitor (NRTI), AZT-PMPA targets HIV infection effectively[2].		HIV Protease
T80398	Brevinin-1PMa
	Brevinin-1PMa is a host-defense peptide with antimicrobial properties effective against both Staphylococcus aureus and Escherichia coli, as well as demonstrated hemolytic activity [1].
TN1441	Beta-Tocopherol		ERK , MAPK
	Beta-Tocopherol shows effect on human erythroleukemia cell (HEL) adhesion induced by phorbol 12-myristate 13-acetate (PMA).		ERK , MAPK
T3860	Isoliquiritin apioside		MMP , p38 MAPK , NF-κB
	Isoliquiritin apioside, isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresse...		MMP , p38 MAPK , NF-κB
T22831	Protein kinase inhibitor H-7 dihydrochloride	H-7 dihydrochloride	PKC
	Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride) is a potent protein kinase C (PKC) inhibitor. Protein kinase inhibitor H-7 dihydrochloride (100 μM) significantly inhibits TPA (skin tumor promoter, 12-O-...		PKC
TN1880	Lucidenic acid B	Lucidenicacid B	Apoptosis , Caspase
	Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mito...		Apoptosis , Caspase
T4S0878	Prunetin	Prunusetin	ERK , Dehydrogenase , NF-κB
	1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit...		ERK , Dehydrogenase , NF-κB
T6S0139	Neobavaisoflavone		Apoptosis , DNA/RNA Synthesis
	1. Neobavaisoflavone is isolated as a DNA polymerase inhibitor. 2. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases. 3. Neobavaisoflavone has anti-inflammatory activity, can si...		Apoptosis , DNA/RNA Synthesis
TN1879	Lucideric acid A	Lucidenic acid A	MMP , p38 MAPK , JNK
	Lucideric acid A (Lucidenic acid A) is a modulator of JNK and p38 and enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK/MAPKs activation.		MMP , p38 MAPK , JNK
T81036	TAT-JIP
	TAT-JIP effectively inhibits the phosphorylation of endogenous c-jun, which is activated by PHA–PMA [1].