PMA

Phorbol 12-myristate 13-acetate (PMA) is a natural phorbol ester that acts as an activator of PKC, SphK, and NF-κB, and is commonly used to induce differentiation of THP-1 cells and establish dermatitis models.

Des(8-14)brevinin-1PMa is a host-defense peptide with potent antimicrobial properties, especially against Staphylococcus aureus and Echerichia coli, and also demonstrates hemolytic activity [1].

Brevinin-1PMa is a host-defense peptide with antimicrobial properties effective against both Staphylococcus aureus and Escherichia coli and exhibits demonstrated hemolytic activity [1].

Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.

Capmatinib xHCl (INCB28060) is a potent, orally active, selective, and ATP competitive c-Met kinase inhibitor, potently blocking in vitro kinase activity (IC50 = 0.13 nM) as well as constitutive or HGF-stimulated activity in cells (IC50 values range from 0.3 to 1.1 nM).

Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.

AZT-PMPA, an aryl phosphate derivative of AZT and a nucleoside analogue, demonstrates anti-HIV activity[1]. As a nucleoside reverse transcriptase inhibitor (NRTI), AZT-PMPA targets HIV infection effectively[2].

Capmatinib (INCB28060) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.

PMAP-23 is an antimicrobial peptide (AMP) with biological activity, derived from porcine myeloid cells.

GPMA is a cationic copolymerization agent used for creating polymer complexes to facilitate the delivery of plasmid DNA in vitro.

PMAL-C8 has a wide range of applications in life science related research.

PMAL-C16 has a wide range of applications in life science related research.

PMAL-C12 has a wide range of applications in life science related research.

4-Hydroxyflavanone is a natural product, shows full vasorelaxing effects

4-PPBP maleate is a potent σ1 receptor (ligand) agonist and a selective, non-competitive NR1a/2B NMDA receptor antagonist in the context of Xenopus oocytes expression, with neuroprotective properties.

MBP MAPK Substrate acetate can be used as an exogenous substrate for MAPK.

Myristoyl-MEK1 Derived Peptide Inhibitor 1, the myristoylated variant of MEK1 Derived Peptide Inhibitor 1, effectively inhibits ERK activation, demonstrating an inhibitory concentration (IC50) of 10 μM [1].

MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.

Ritipenem Acoxil is an antibiotics.

Preincubation of guinea pig brain membranes with BTCP was shown to produce an increase in the dissociation rate of [3H]TCP from PCP site.

MBP (MAPK) Substrate is an exogenous substrate utilized for MAPK.

Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

JZP-MA-13 is a selective α/β-hydrolase domain 6 (ABHD6) inhibitor with an IC50 value of 392 nM, and exhibits no inhibitory effects on monoacylglycerol lipase (MAGL), ABHD12, fatty acid amide hydrolase (FAAH), or other serine hydrolases. JZP-MA-13 also serves as a positron emission tomography (PET) ligand for in vivo imaging of ABHD6.