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Results for "

Aldose Reductase

" in TargetMol Product Catalog
  • Inhibitor Products
    76
    TargetMol | Activity
  • Natural Products
    29
    TargetMol | inventory
  • Recombinant Protein
    2
    TargetMol | natural
Aldose reductase-IN-1
T141751355612-71-3
Aldose reductase-IN-1 (AT-001) is a aldose reductase inhibitor (IC50: 28.9 pM).
  • $70
In Stock
Size
QTY
TargetMol | Inhibitor Hot
Aldose reductase-IN-4
T606012446136-17-8
Aldose reductase-IN-4 (compund IIc) is an inhibitor of aldose reductase with IC50s of 11.70 μM and 0.98 μM for ALR1 and ALR2, respectively [1].
  • $1,520
6-8 weeks
Size
QTY
Aldose reductase-IN-5
T608972480090-03-5
Aldose reductase-IN-5 is an inhibitor of aldose reductase (ALR2) that enhances the combination of inhibitory excitability and antioxidant capacity, thereby delaying the diabetes complications progress.
  • $1,520
6-8 weeks
Size
QTY
Aldose reductase-IN-3
T619571390616-76-8
Aldose reductase-IN-3 (Compound 5) is an effective and moderately selective aldose reductase (AR) inhibitor (IC50=3.99 μ M). Aldose reductase is a molecular target involved in various inflammatory diseases (including sepsis). Aldose reductase-IN-3 has research potential in sepsis.
  • $1,520
6-8 weeks
Size
QTY
Aldose reductase-IN-6
T615552470019-41-9
Aldose reductase-IN-6 (Compound 3) is a competitive inhibitor of aldose reductase (AR), possessing an IC50 of 3.164 μM and a Ki of 0.018 μM. Notably, Aldose reductase-IN-6 demonstrates no cytotoxicity toward normal cells [1].
  • $1,520
6-8 weeks
Size
QTY
Aldose reductase-IN-2
T629511687735-82-5
Aldose reductase-IN-2 (Compound 5f) is a potent inhibitor of aldose reductase (AR) with antioxidant properties. aldose reductase-IN-2 is a promising anti-diabetic complication drug.
  • $2,140
6-8 weeks
Size
QTY
Alconil
T2984497677-19-5In house
Alconil (Al 1567) is an aldose reductase inhibitor that may be used to study chronic obstructive pulmonary disease (COPD) and diabetes.
  • $293 TargetMol
In Stock
Size
QTY
Sulindac sulfide
T1303749627-27-2In house
Sulindac sulfide (cis-Sulindac sulfide) is a non-steroidal anti-inflammatory compound that has a high affinity for COX-1 and acts as an inhibitor in Ras activation of Raf-1. Sulindac sulfide is a non-competitive inhibitor of gamma-secretase with an IC50 value of 20.2 μM. It is an active metabolite of sulinic acid.
  • $31
In Stock
Size
QTY
Isoliquiritigenin
T0725961-29-5
Isoliquiritigenin (ISL), an anti-tumor flavonoid from the root of Glycyrrhiza glabra, suppresses aldose reductase (IC50=320 nM).
  • $50
In Stock
Size
QTY
TargetMol | Citations Cited
Oxepinac
T6780555689-65-1In house
oxepinac is an effective and well-tolerated compound for the treatment of painful osteoarthritis. oxepinac has no teratogenic effect on mouse and rabbit fetuses in animal experiments.
  • $240
In Stock
Size
QTY
IDD388
T27583314297-26-2
IDD388 is a selective and potent aldose reductase (ALR2) inhibitor with antitumor activity that inhibits the ALR1 receptor.
  • $123
In Stock
Size
QTY
Minalrestat
T33389129688-50-2In house
Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.
  • $258
In Stock
Size
QTY
Lidorestat
T15756245116-90-9In house
Lidorestat (IDD-676) is an aldose reductase inhibitor (IC50: 5 nM) with effective, selective and oral activity. Lidorestat improves nerve conduction and reduces the formation of cataracts. Lidorestat can be used to treat complications of chronic diabetes.
  • $42
In Stock
Size
QTY
Tolrestat
T1711482964-04-3In house
Tolrestat (AY-27773) is a potent inhibitor of aldose reductase (IC50 = 35 nM).
  • $40
In Stock
Size
QTY
Engeletin
T6S0840572-31-6
1. Engeletin (Dihydrokaempferol 3-rhamnoside) may serve as a potential anti-inflammatory agent. 2. Engeletin possesses potent inhibition of PGE2 release with IC5 values of 19.6 μg/ml. 3. Engeletin inhibits a recombinant human aldose reductase (IC5 value=1.16 microM).
  • $41
In Stock
Size
QTY
TargetMol | Citations Cited
Epalrestat
T145882159-09-9
Epalrestat (ONO2235), an aldose reductase inhibitor, is well tolerated in Long-term therapy. It can effectually ameliorate the associated symptoms of diabetic neuropathy and delay the progression of the disease, particularly in patients with limited microangiopathy and good glycemic control.
  • $30
In Stock
Size
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TargetMol | Citations Cited
Ganoderic acid Df
T756271352033-73-8
Ganoderic acid Df, a lanostane-type triterpenoid isolated from the fruiting body of Ganoderma lucidum, potently inhibits aldose reductase with an IC 50 of 22.8 ± 0.6 μM [1].
  • Inquiry Price
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TargetMol | Inhibitor Sale
WJ-39
T843453009908-95-3
WJ-39 is an orally active aldose reductase (AR) inhibitor that ameliorates renal lesions in diabetic nephropathy through activation of Nrf2 signaling, and may be used to ameliorate renal insufficiency and fibrosis.WJ-39 inhibits oxidative stress and inhibits the activation of the inflammatory vesicle of the oligomerization structural domain-like receptor family, pyrin structural domain 3 (NLRP3).
  • $117
In Stock
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QTY
TargetMol | Inhibitor Sale
Conduritol A
TN3692526-87-4
Conduritol A has a hypoglycemic effect, can have an effect on regulating the metabolism of blood lipid, free-radical scavenging, enhancing the antioxidant ability, potentiating immune function; it also can markedly prevent the diabetic rats from getting c
  • $618
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QTY
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EBPC
T227574450-98-0
EBPC is an inhibitor of aldose reductase.
  • $87
In Stock
Size
QTY
TargetMol | Inhibitor Sale
2-Chloro-1-(4-fluorobenzyl)benzimidazole
T747884946-20-3
2-Chloro-1-(4-fluorobenzyl)benzimidazole is an inhibitor of aldose reductase (ALR2).
  • $37
In Stock
Size
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TargetMol | Inhibitor Sale
Danshenol A
TN3760189308-08-5
Danshenol A has strong aldose reductase (AR) inhibitory activity, has IC50 of 0.10 microM which is comparable to that of epalrestat in clinical use. Danshenol A also has antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines, shows inhibited growth of K562 (IC50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines.
  • $1,786
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APPA
T78612100750-39-8
APPA, an aldose reductase inhibitor, demonstrates efficacy in preventing apoptosis and symptoms of Streptozotocin-induced diabetes in rats through inhibition of the polyol pathway. This compound shows promise for research into diabetic nephropathy (DN) [1].
  • $1,520
6-8 weeks
Size
QTY
6-Hydroxyluteolin
T7900518003-33-3
6-Hydroxyluteolin (Compound 17), a flavonoid, exhibits inhibition of aldose reductase (AR) [1].
  • $1,520
6-8 weeks
Size
QTY
Groenlandicine
TN103738691-95-1
Groenlandicine is a protoberberine alkaloid from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR). Groenlandicine selectively induces topoisomerase I-mediated DN
  • $93
In Stock
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Sorbinil
T1691068367-52-2
Sorbinil is an Aldose reductase inhibitor. Sorbinil plays a therapeutic role in treating diabetes and diabetic complications decreases AR activity and inhibit the polyol pathway.
  • $39
In Stock
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Dehydroglyasperin D
TMA0291517885-72-2
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet oxygen radicals.
  • $1,670
6-8 weeks
Size
QTY
Alrestatin
T519551411-04-2
Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
  • $64
In Stock
Size
QTY
Triptocalline A
TN5183201534-10-3
Triptocalline A, a compound from Salacia chinensis, inhibits rat lens aldose reductase.
  • $1,879
7-10 days
Size
QTY
TargetMol | Inhibitor Sale
Ganoderenic acid A
TN1656100665-40-5
Ganoderenic acid A has a potent hepatoprotective, and cytotoxic effects, it shows inhibitory activity on human aldose reductase in vitro.
  • $58
In Stock
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Imirestat
T1556889391-50-4
Imirestat (HOE 843) is an aldose reductase inhibitor that can be used in diabetes research.
  • $123
In Stock
Size
QTY
3-Isomangostin
T2S163519275-46-8
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial activity with IC50 values in the rang
  • $35
In Stock
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Zenarestat
T35299112733-06-9
Zenarestat (CI-1014, FK-366, FR-74366) is an aldose reductase inhibitor being studied as a treatment for diabetic neuropathy and cataracts.
  • $877
6-8 weeks
Size
QTY
2'-acetylacteoside
T610294492-24-7
2'-Acetylacteoside has antioxidative activity. It can significantly attenuate glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM. 2'-Acetylacteoside shows antiproliferative effects on aortic smooth muscle, indicates that it may ha
  • $60
In Stock
Size
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WF 2421
T71057128429-19-6
WF 2421 is an aldose reductase inhibitor produced by Humicola grisea.
  • $1,520
6-8 weeks
Size
QTY
Lucidumol A
TN6645217476-73-8
Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36
  • $900
Backorder
Size
QTY
ALR2-IN-2
T73304
ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, exhibits IC50 values of 27 nM for rat ALR2 and 228 nM for ALR1, respectively. This compound is utilized in the research of diabetic complications.
  • $1,520
6-8 weeks
Size
QTY
AT-007
T103932170729-29-8
AT-007 is an orally active CNS penetrant Aldose Reductase inhibitor for the treatment of Galactosemia (IC50: 100 pM). It reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.
  • $73
In Stock
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ALR1/2-IN-1
T624562419233-57-9
ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) (IC50: 3.26 μM) and aldose reductase (ALR2) (IC50: 3.06 μM) inhibitor with anticancer effects.
  • $1,520
6-8 weeks
Size
QTY
Isorhamnetin-3-O-glucoside
T5S19885041-82-7
Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.
  • $72
In Stock
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Poliumoside
T6S238494079-81-9
Poliumoside is a natural compound which exhibits significant inhibition of advanced glycation end product formation with IC50 value of 4.6-25.7 μM, it also exhibits great inhibitory effects on rat lens aldose reductase with IC50 values of 0.85 μM.Poliumos
  • $47
In Stock
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Ponalrestat
T201372702-95-5
Ponalrestat is an aldose reductase inhibitor.
  • $39
In Stock
Size
QTY
Lidorestat monohydrate
T68929653599-32-7
Lidorestat monohydrate is an aldose reductase inhibitor potentially for the treatment of diabetic neuropathy and diabetic complications.
  • $1,820
1-2 weeks
Size
QTY
(Rac)-Byakangelicin
T380119573-01-4
(Rac)-Byakangelicin (7H-Furo[3,2-g][1]benzopyran-7-one, 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-) is an antineoplastic agent.
  • $40
In Stock
Size
QTY
M 16287
T71052128851-55-8
M 16287 is a potent aldose reductase inhibitor.
  • $1,520
6-8 weeks
Size
QTY
Ganoderic acid C2
TN1661103773-62-2
Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen.
  • $55
In Stock
Size
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CP-744809
T31075463976-07-0
CP-744809 is a highly selective oral small-molecule aldose reductase inhibitor.
  • $1,520
6-8 weeks
Size
QTY
ICI-105552
T6865181420-31-7
ICI-105552 is an aldose reductase inhibitor.
  • $1,520
6-8 weeks
Size
QTY
ALR2-IN-3
T73305
ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, demonstrates IC50 values of 22 nM for rat ALR2 and 116 nM for ALR1, respectively. This compound is utilized in diabetic complications research.
  • $1,520
6-8 weeks
Size
QTY
8-Lavandulylkaempferol
TN3287883859-83-4
8-Lavandulylkaempferol exhibits significant inhibitory effects with IC(50) values of 7.10 and 8.11 microM for butyrylcholinesterase and acetylcholinesterase, respectively. It shows inhibitory activities against aldose reductase, with the the IC50 of 0.79 microM.
  • $670
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