Neural dyes

Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.

Sulforhodamine 101 (SR101) is a red fluorescent dye.

BTC AM is a cell-permeable acetoxy-methyl ester of BTC . As BTC AM enters cells, it is hydrolyzed by intracellular esterases to produce BTC. BTC is a low affinity calcium indicator (Kd = 7-26 μM) that displays excitation emission spectra of 401 529 nm, respectively. It exhibits a shift in the excitation maximum from approximately 480 to 401 nm upon calcium binding, enabling determination of ratiometric calcium measurements. BTC is suitable for detecting elevated calcium levels associated with activation of smooth muscle, neurons, and intracellular calcium stores.

True blue is a fluorescent neuronal retrograde tracer that labels the nucleus, nucleolus, cell body, proximal dendrites, and axons of neurons. It displays excitation emission maxima of 373 404 nm, respectively.

Cresyl Violet perchlorate is a red fluorescent stain employed for neuron staining.

Cresyl Violet acetate, a red fluorescent stain, is employed for staining neurons.

Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, acts as a potent antagonist against the neuropeptide Y Y1 receptor (Y1R) with a Kᵢ value of 0.19 nM [1]. It should be stored in conditions shielded from light.