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Apoptosis detection

Apoptosis detection dyes are a class of chemical reagents used to identify and quantify the process of apoptosis. They are detected by binding to phosphatidylserine, DNA breaks or caspase activity and are widely used in disease research and drug development.

  • Propidium Iodide
    T213025535-16-4
    Propidium Iodide (PI) is a red fluorescent dye utilized for cell staining and is suitable for fluorescence microscopy, confocal microscopy, flow cytometry, and fluorometer analysis. In aqueous solution, the Ex/Em of PI is 493/636 nm. Upon binding with nucleic acid, the Ex/Em shifts to 535/617 nm, enhancing the fluorescence signal 20-30 times.
    • $30
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  • JC-1
    T156093520-43-2
    JC-1 (CBIC2) is a fluorescent lipophilic carbonyl cyanine dye. JC-1 is used to measure mitochondrial membrane potential. When the mitochondrial membrane potential is relatively high, JC-1 converges in the matrix to form a polymer, which can produce red fluorescence (λex=585 nm, λem=590 nm). When the mitochondrial membrane potential is low, JC-1 cannot accumulate in the mitochondrial matrix and exists in the form of monomers to produce green fluorescence (λex=510 nm, λem=527 nm).
    • $59
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  • Calcein-AM
    T18931148504-34-1
    Calcein-AM (Calcein acetoxymethyl ester) is a cell-permeable green fluorescent probe commonly used for assessing eukaryotic cell viability or mitochondrial permeability transition pore, with no fluorescence itself. After hydrolysis, it emits green fluorescence with excitation/emission wavelengths: 494/515 nm.
    • $265
    35 days
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  • BBR-BODIPY
    T746262456476-47-2
    BBR-BODIPY, a fluorescent probe, facilitates the screening of its interactions with targeted cells, induces apoptosis, and alters the expression of apoptosis-related proteins [1]. Storage instructions include protection from light.
    • $97
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    TargetMol | Citations Cited
  • XTT (sodium salt hydrate)
    T37583413585-64-5
    XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator [1,2]. It is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis [3].
    • $198
    35 days
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  • 7-Aminoactinomycin D
    T189067240-37-1
    7-Aminoactinomycin D is a fluorescent DNA stain.
    • $275
    35 days
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  • Z-DEVD-R110
    T87662223538-61-2
    Z-DEVD-R110 ((Z-Asp-Glu-Val-Asp) 2 -Rhodamine 110), a rhodamine derivative featuring two four–amino acid (DEVD) peptides attached to the fluorophore [1], serves as a fluorogenic substrate for caspase-3 7. This compound is utilized for detecting apoptosis, leveraging its design to bind and indicate caspase activation.
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