c-Met/HGFR

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing.

Cat. No.	Product name	CAS No.	Purity
T3512	S49076 HCl	1265966-31-1	98%
T3512	S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
TN4474	Macrocarpal B	142698-60-0	98%
TN4474	The intestinal absorption of M-A, Macrocarpal B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent.
T15384	Glesatinib	936694-12-1	98%
T15384	Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multi...
T12418	PF-04217903 phenolsulfonate	1159490-85-3	98%
T12418	PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
T10654	C-Met-IN-2	1635406-73-3	98%
T10654	c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.
T15383	Glesatinib hydrochloride	1123838-51-6	98%
T15383	Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO. Glesatinib hydrochloride is also a tyrosine kinase inhibitor. It antagonizes P...
T10653	C-met-IN-1	2084836-84-8	98%
T10653	c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.
T12417	PF-04217903 methanesulfonate	956906-93-7	98%
T12417	PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
T37596	Terevalefim	1070881-42-3	98%
T37596	Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.
T11162	EGFR-IN-8	2407957-87-1	98%
T11162	EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.
T63313	Unecritinib	1418026-92-2	98%
T63313	Unecritinib (TQ-B3101) is a potent, orally active, highly potent, blood-brain barrier permeable and low toxic inhibitor of EGFR tyrosine kinase with antitumor ac...
T7787	BMS817378	1174161-69-3	98%
T7787	BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).
T4260	Capmatinib 2HCl	1197376-85-4	98%
T4260	INCB-28060(free base) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.INCB28060 exhibits picomolar enzymatic potency and is highl...
T5414	Glumetinib	1642581-63-2	98%
T5414	Glumetinib (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).
T2185	L-Ascorbic acid 2-phosphate trisodium	66170-10-3	98%
T2185	L-Ascorbic acid 2-phosphate (AA2P) is used in biocatalytic dephosphorylation for electric power generation and electrochemical detection assays.
T2208	Bacitracin Zinc	1405-89-6	98%
T2208	Bacitracin Zinc is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, interference for inhibition of cleavage of Tyr from M...
T5677	SAR125884 hydrochlorid (1116743-46-4(free base))	T5677	98%
T5677	SAR125844 is a potent and selective MET kinase inhibitor with a favorable preclinical toxicity profile,(IC50=4.2 nM).
T67859	N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenylpropanohydrazide	299405-67-7	98%
T67859	N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)-3-phenylpropanohydrazide is a c-Met kinase inhibitor.
T39507L	Fosgonimeton acetate		98%
T39507L	Fosgonimeton aceate is an agonist of hepatocyte growth factor (HGF).
T5164	Cabozantinib hydrochloride	1817759-42-4	98%
T5164	Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).