c-Met/HGFR

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing.

Cat. No.	Product name	CAS No.	Purity
T3512	S49076 HCl	1265966-31-1	98%
T3512	S49076 is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream...
T6378	AMG-458	913376-83-7	98%
T6378	AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
TN4474	Macrocarpal B	142698-60-0	98%
TN4474	The intestinal absorption of M-A, Macrocarpal B, and Cy-C was passive diffusion as the dominating process and Cy-C was partly ATP-dependent.
T12417	PF-04217903 methanesulfonate	956906-93-7	98%
T12417	PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
T15384	Glesatinib	936694-12-1	98%
T15384	Glesatinib is an orally active and potent dual inhibitor of MET/SMO. Glesatinib is also a tyrosine kinase inhibitor. It antagonizes P-glycoprotein mediated multi...
T15383	Glesatinib hydrochloride	1123838-51-6	98%
T15383	Glesatinib hydrochloride is an orally active and potent dual inhibitor of MET/SMO. Glesatinib hydrochloride is also a tyrosine kinase inhibitor. It antagonizes P...
T8409	SYN1143	913376-84-8	98%
T8409	AMG-1 is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and...
T10653	C-met-IN-1	2084836-84-8	98%
T10653	c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.
T12418	PF-04217903 phenolsulfonate	1159490-85-3	98%
T12418	PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
T10654	C-Met-IN-2	1635406-73-3	98%
T10654	c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.
T37596	Terevalefim	1070881-42-3	98%
T37596	Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.
T9601	Tepotinib hydrochloride(1 : x)	1103508-80-0	98%
T9601	Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 s...
T11162	EGFR-IN-8	2407957-87-1	98%
T11162	EGFR-IN-8 can be a promising candidate for further development to target EGFR TKI-resistant NSCLC. EGFR-IN-8 is a dual EGFR and c-Met inhibitor.
T2349	BMS-754807	1001350-96-4	98%
T2349	Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine ...
T6154	SU11274	658084-23-2
T6154	SU11274(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
T2185	L-Ascorbic acid 2-phosphate trisodium	66170-10-3	100%
T2185	L-Ascorbic acid 2-phosphate (AA2P) is used in biocatalytic dephosphorylation for electric power generation and electrochemical detection assays.
T7787	BMS817378	1174161-69-3	100%
T7787	BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).
T5414	Glumetinib	1642581-63-2	100%
T5414	Glumetinib (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).
T4260	Capmatinib 2HCl	1197376-85-4	100%
T4260	INCB-28060(free base) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.INCB28060 exhibits picomolar enzymatic potency and is highl...
T2208	Bacitracin Zinc	1405-89-6	63.98%
T2208	Bacitracin Zinc is an antibiotic that interferes with the dephosphorylation of C55-isoprenyl pyrophosphate, interference for inhibition of cleavage of Tyr from M...