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P-gp

P-glycoprotein (P-gp) is a plasma membrane protein which acts as a localized drug transport mechanism, actively exporting drugs out of the cell. The effects of P-gp on the distribution, metabolism and excretion of drugs — including protease inhibitors — in the body is great.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T64133L Laniquidar TFA 98.74%
Laniquidar TFA
Laniquidar TFA (R101933) is a novel orally available non-competitive P-glycoprotein (P-gp) inhibitor with an IC50 value of 0.51 μM.Laniquidar has limited bioavai...
TCS2336 Evodine 6989-38-4
Evodine
1. Evodine has antinociceptive activity.
TN2257 Tanshinone IIB 17397-93-2 98%
Tanshinone IIB
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4410 Lappaol C 64855-00-1 98%
Lappaol C
Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also ...
TN2726 Jatrophane 5 210108-89-7 98%
Jatrophane 5
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-Tx...
TQ0043 Dofequidar 129716-58-1 98%
Dofequidar
Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
TN5124 Taxuspine X 194782-02-0 98%
Taxuspine X
Taxuspine X may have p-glycoprotein inhibitory activity.
TN5114 Taxinine 3835-52-7 98%
Taxinine
Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
TN4819 (-)-Praeruptorin A 14017-71-1 98%
(-)-Praeruptorin A
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depen...
TN4749 Pepluanin A 670257-89-3 98%
Pepluanin A
Pepluanin A, shows a very high activity for a jatrophane diterpene, outperforming cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated dauno...
TN4411 Lappaol F 69394-17-8 98%
Lappaol F
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade.
2. Lap...
TN1099 Dihydroevocarpine 15266-35-0 98%
Dihydroevocarpine
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a...
TN3937 Ent-16alpha,17-Dihydroxyatisan-3-one 112523-91-8 98%
ent-16alpha,17-Dihydroxyatisan-3-one
ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymp...
TN2263 Tenacigenin B 80508-42-5 98%
Tenacigenin B
Tenacigenin B is a natural product of Marsdenia, Asclepiadaceae. The catalog number is TN2263 and the CAS number is 80508-42-5. Tenacigenin B can be used as a re...
TN2727 Jatrophane 2 210108-86-4 98%
Jatrophane 2
2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-fee...
TN1072 Lappaol A 62333-08-8 98%
Lappaol A
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also ...
T16561 Polyoxyethylene stearate 9004-99-3 polymer
Polyoxyethylene stearate
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
T4A2399 Cinobufotalin 1108-68-5 99.94%
Cinobufotalin
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide pr...
T8426 Encequidar 849675-66-7 99.93%
Encequidar
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
T2S1200 Sinapine 18696-26-9 99.85%
Sinapine
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant an...
Laniquidar TFA
T64133L
Laniquidar TFA (R101933) is a novel orally available non-competitive P-glycoprotein (P-gp) inhibitor with an IC50 value of 0.51 μM.Laniquidar has limited bioavai...
Evodine
TCS2336
1. Evodine has antinociceptive activity.
Tanshinone IIB
TN2257
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
Lappaol C
TN4410
Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also ...
Jatrophane 5
TN2726
Jatrophane 5 demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-Tx...
Dofequidar
TQ0043
Dofequidar (MS-209) is a quinoline compound that can reverse P-glycoprotein (P-gp)-mediated MDR.
Taxuspine X
TN5124
Taxuspine X may have p-glycoprotein inhibitory activity.
Taxinine
TN5114
Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
(-)-Praeruptorin A
TN4819
(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings depen...
Pepluanin A
TN4749
Pepluanin A, shows a very high activity for a jatrophane diterpene, outperforming cyclosporin A by a factor of at least 2 in the inhibition of Pgp-mediated dauno...
Lappaol F
TN4411
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lap...
Dihydroevocarpine
TN1099
Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a...
ent-16alpha,17-Dihydroxyatisan-3-one
TN3937
ent-16alpha,17-Dihydroxyatisan-3-one and ent-16alpha,17-dihydroxykauran-3-one have apoptosis induction activities on L5178 human MDR1 gene-transfected mouse lymp...
Tenacigenin B
TN2263
Tenacigenin B is a natural product of Marsdenia, Asclepiadaceae. The catalog number is TN2263 and the CAS number is 80508-42-5. Tenacigenin B can be used as a re...
Jatrophane 2
TN2727
2,5,7,8,9,14-Hexaacetoxy-3-benzoyloxy-15-hydroxyjatropha-6(17),11E-diene (Jatrophane 2 ) exhibits significant antifeedant activity against a generalist plant-fee...
Lappaol A
TN1072
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also ...
Polyoxyethylene stearate
T16561
Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.
Cinobufotalin
T4A2399
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide pr...
Encequidar
T8426
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
Sinapine
T2S1200
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant an...
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TargetMol