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Myosin

Myosins are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are ATP-dependent and responsible for actin-based motility.

  • Blebbistatin
    T21550674289-55-5
    Blebbistatin ((±)-Blebbistatin) is a selective non-muscle myosin II (NMII) inhibitor. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing. Furthermore it preserves cell junctional integrity and barrier function.Blebbistatin is an inhibitor of MYH9.
    • $30
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    TargetMol | Inhibitor Hot
  • JB062
    T679522417988-00-0
    JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac muscle myosin, and smooth muscle myosin II, respectively. It selectively exhibits cytotoxicity towards human cancer cells without affecting normal cells. The compound is applicable in research fields concerning muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.
    • $195
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  • Phenamacril
    T2421439491-78-6
    Phenamacril (JS39919) is acyanoacrylate fungicide, has powerful inhibition against Fusarium species, especially to Fusarium graminearum. Phenamacril is a specific Fusarium myosin I inhibitor.
    • $148
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  • ATM-3507
    T10395L1861449-70-8In house
    ATM-3507 is a protomyosin inhibitor with anticancer activity that inhibits human melanoma and can be used to study ovarian cancer.
    • $117
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    TargetMol | Inhibitor Sale
  • Myosin V-IN-1
    T720601259177-59-7In house
    Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.
    • $330
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    TargetMol | Inhibitor Sale
  • para-Nitroblebbistatin
    T123601621326-32-6In house
    para-Nitroblebbistatin (p-Nitroblebbistatin) is a non-cytotoxic, fluorescent, photostable and specific Myosin II inhibitor. para-Nitroblebbistatin can be used in the study of the special role of myosin II in developmental, physiological,, and cell biological studies.
    • $148
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  • ML-7 hydrochloride
    T3050110448-33-4
    ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and PKC.
    • $42
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    TargetMol | Citations Cited
  • ML-9
    T16104105637-50-1
    ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.
    • $34
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    TargetMol | Citations Cited
  • (-)-Blebbistatin
    T6038856925-71-8
    (-)-Blebbistatin ((S)-(-)-Blebbistatin) is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM.
    • $35
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    TargetMol | Citations Cited
  • HA-100
    T764884468-24-6
    HA-100 is an inhibitor of protein kinase
    • $57
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    TargetMol | Citations Cited
  • 16-38-Thymosin β4 (cattle) (TFA)
    T80088
    Thymosin β4 (cattle) TFA is a high-affinity activator of MLCK that operates independently of Ca2+ [1].
    • Inquiry Price
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  • Omecamtiv mecarbil
    T2006873697-71-3
    Omecamtiv mecarbil (CK-1827452) has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among others.
    • $34
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  • JB002
    T7202330408-07-2
    JB002, a myosin II inhibitor, exhibits potent activity with an IC50 of ≤10 μM. It holds potential for research applications in muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.
    • $70
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  • Danicamtiv
    T150501970972-74-7
    Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
    • $138
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  • BTS
    T71441576-37-0
    BTS (N-Tosylbenzylamine) is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) .
    • $29
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  • Pentachloropseudilin
    T2461269640-38-6
    Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi.
    • $1,520
    Backorder
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  • W-7 hydrochloride
    T2079261714-27-0
    W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
    • $30
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  • JB061
    T67951
    JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II). It exhibits limited efficacy in reducing ATPase activity, with an IC50 exceeding 200 μM. Furthermore, JB061 displays cytotoxic effects on COS-7 cells, evidenced by an IC50 value of 39 μM.
    • $33
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  • Mavacamten
    T71341642288-47-8
    Mavacamten (MYK-461) is an orally bioavailable inhibitor of cardiac myosin ATPase,( IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively)
    • $55
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