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CaSR

The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ion. It is primarily expressed in the parathyroid gland and the renal tubules of the kidney.

  • Strontium chloride
    T2340110476-85-4
    Strontium chloride is an agonist of Calcium sensing receptor (CaSR) and directly affects C-type nerve fibers.
    • $50
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  • Ronacaleret HCl
    T34385702686-96-2In house
    Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.
    • $290
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  • Upacicalcet HCl
    T29067L In house
    Upacicalcet HCl is an intravesical calcium mimetic that inhibits excessive parathyroid hormone (PTH) secretion by directly acting on calcium-sensitive receptors in parathyroid cell membranes, thereby lowering PTH levels in the blood.Upacicalcet HCl can be used for the treatment of blood Upacicalcet HCl is a novel compound for the treatment of secondary hyperparathyroidism, targeting amino acid-binding sites of calcium-sensitive receptors. binding sites.
    • $179
    In Stock
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  • Tecalcet Hydrochloride
    T13918177172-49-5In house
    Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+.
    • $30
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  • Calindol hydrochloride
    T21758729610-18-8In house
    Calindol hydrochloride is a potent orthosteric modulator (EC50: 132 nM) of the putative calcium-calcium-sensitive receptor (CaSR), inhibits Pi-induced VC, and delays the progression of calcification in vascular smooth muscle cells.
    • $63
    In Stock
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  • Gadolinium chloride
    T2279510138-52-0
    Gadolinium chloride is a calcium-sensing receptor (CaSR) agonist
    • $41
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    TargetMol | Citations Cited
  • AC265347
    T295411253901-26-6
    AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to study neuroblastoma.
    • $32
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  • SB-423562
    T12846351490-27-2
    SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.
    • $55
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  • Ligustroflavone
    T3802260413-62-5
    Ligustroflavone (Nuezhenoside) has anti-inflammatory activity.
    • $44
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  • Poly-D-lysine hydrobromide (MW 30000-70000)
    T4036327964-99-4
    Poly-D-lysine hydrobromide (MW 30000-70000)(Poly-D-lysine HBr) is an orally available peptide CaSR agonist that removes proteinase K-resistant PrP from prion-infected SN56 neuroblastoma cells.
    • $30
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  • NPS-2143 hydrochloride
    T4967324523-20-8
    NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist.
    • $38
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  • Evocalcet
    T15261870964-67-3
    Evocalcet (KHK7580) has an activating effect on the calcium-sensing receptor (CaSR).
    • $33
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  • Calhex 231 hydrochloride
    T106662387505-78-2
    Calhex 231 hydrochloride is a CaSR inhibitor with the potential for diabetic cardiomyopathy treatment. It blocks Ca2+-induced accumulation of [3H]inositol phosphate (IC50: 0.39 μM in HEK293 cells).
    • $88
    5 days
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  • NPS-2143
    T1730284035-33-2
    NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.
    • $47
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  • Cinacalcet hydrochloride
    T2406364782-34-3
    Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-sensing receptors to serum calcium. This action reduces parathyroid hormone secretion and decreases serum calcium in the treatment of PARATHYROID DISEASES.
    • $43
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  • Etelcalcetide hydrochloride
    TP12361334237-71-6
    Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide that acts as an allosteric modulator of the calcium-sensing receptor (CaSR), effectively lowering parathyroid hormone (PTH) levels in patients with secondary hyperparathyroidism undergoing hemodialysis.
    • $30
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  • Cinacalcet
    T8403226256-56-0
    Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease .
    • $43
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  • CaSR antagonist-1
    T790231219811-83-2
    CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation of diseases related to dysregulated bone or mineral homeostasis, including osteoporosis [1].
    • Inquiry Price
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  • Strontium ranelate
    T1641135459-87-9
    Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both increases deposition of new bone by osteoblasts and reduces the resorption of bone by osteoclasts. It is therefore promoted as a dual action bone agent (DABA) indicated for use in the treatment of severe osteoporosis.
    • $32
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