Shopping Cart

Your shopping cart is currently empty

Tecalcet Hydrochloride

Name: Tecalcet Hydrochloride
Brand: TargetMol
SKU: T13918
Price: 373 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13918Cas No. 177172-49-5

Alias R-568 hydrochloride, R-568 (hydrochloride)

Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+.

Tecalcet Hydrochloride

🥰Excellent

Purity: 99.97%

Catalog No. T13918Alias R-568 hydrochloride, R-568 (hydrochloride)Cas No. 177172-49-5

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$42	In Stock	In Stock
10 mg	$69	In Stock	In Stock
25 mg	$157	In Stock	In Stock
50 mg	$256	In Stock	In Stock
100 mg	$373	In Stock	In Stock
200 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:99.97%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+.
In vitro	Tecalcet Hydrochloride (0.1-100 nM) shifts the concentration-response curve for extracellular Ca2 to the left and decreases the EC50 value to 0.61 mM. Tecalcet Hydrochloride (0.1-100 μM) increases Ca2+ in a dose-dependent and stereoselective manner[3].
In vivo	In male Sprague-Dawley rats with renal insufficiency, Tecalcet Hydrochloride (1.5 and 15 mg/kg, oral) inhibits PT cell proliferation and reduces serum PTH level in a dose-dependent manner. Tecalcet Hydrochloride reduces the number of BrdU-positive PT cells by 20% at a low dose (1.5 mg/kg), and by 50% at a high dose (15 mg/kg)[1].
Synonyms	R-568 hydrochloride, R-568 (hydrochloride)

Chemical Properties

Molecular Weight	340.29
Formula	C₁₈H₂₃Cl₂NO
Cas No.	177172-49-5
Smiles	Cl.COc1cccc(c1)[C@@H](C)NCCCc1ccccc1Cl
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (132.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9387 mL	14.6933 mL	29.3867 mL	146.9335 mL
5 mM	0.5877 mL	2.9387 mL	5.8773 mL	29.3867 mL
10 mM	0.2939 mL	1.4693 mL	2.9387 mL	14.6933 mL
20 mM	0.1469 mL	0.7347 mL	1.4693 mL	7.3467 mL
50 mM	0.0588 mL	0.2939 mL	0.5877 mL	2.9387 mL
100 mM	0.0294 mL	0.1469 mL	0.2939 mL	1.4693 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc