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Tecalcet Hydrochloride

Name: Tecalcet Hydrochloride
Brand: TargetMol
SKU: T13918
Price: 373 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13918Cas No. 177172-49-5

Alias R-568 hydrochloride, R-568 (hydrochloride)

Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+.

Tecalcet Hydrochloride

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Purity: 99.97%

Catalog No. T13918Alias R-568 hydrochloride, R-568 (hydrochloride)Cas No. 177172-49-5

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$42	In Stock	In Stock
10 mg	$69	In Stock	In Stock
25 mg	$157	In Stock	In Stock
50 mg	$256	In Stock	In Stock
100 mg	$373	In Stock	In Stock
200 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Tecalcet Hydrochloride (R-568 hydrochloride) is an allosteric and positive modulator of the calcium-sensing receptor(CaSR). Tecalcet Hydrochloride increases the sensitivity to the activation of extracellular Ca2+.
In vitro	Tecalcet Hydrochloride (0.1-100 nM) shifts the concentration-response curve for extracellular Ca2 to the left and decreases the EC50 value to 0.61 mM. Tecalcet Hydrochloride (0.1-100 μM) increases Ca2+ in a dose-dependent and stereoselective manner[3].
In vivo	In male Sprague-Dawley rats with renal insufficiency, Tecalcet Hydrochloride (1.5 and 15 mg/kg, oral) inhibits PT cell proliferation and reduces serum PTH level in a dose-dependent manner. Tecalcet Hydrochloride reduces the number of BrdU-positive PT cells by 20% at a low dose (1.5 mg/kg), and by 50% at a high dose (15 mg/kg)[1].
Synonyms	R-568 hydrochloride, R-568 (hydrochloride)

Chemical Properties

Molecular Weight	340.29
Formula	C₁₈H₂₃Cl₂NO
Cas No.	177172-49-5
Smiles	Cl.COc1cccc(c1)[C@@H](C)NCCCc1ccccc1Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (440.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.88 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9387 mL	14.6933 mL	29.3867 mL	146.9335 mL
5 mM	0.5877 mL	2.9387 mL	5.8773 mL	29.3867 mL
10 mM	0.2939 mL	1.4693 mL	2.9387 mL	14.6933 mL
20 mM	0.1469 mL	0.7347 mL	1.4693 mL	7.3467 mL
50 mM	0.0588 mL	0.2939 mL	0.5877 mL	2.9387 mL
100 mM	0.0294 mL	0.1469 mL	0.2939 mL	1.4693 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc