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  • Tyrosine Kinases
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Results for "

tyk 2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    15
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    2
    TargetMol | Recombinant_Protein
  • Isotope Products
    1
    TargetMol | Isotope_Products
  • Antibody Products
    1
    TargetMol | Antibody_Products
Ruxolitinib
INCB018424, (R)-Ruxolitinib
T1829941678-49-5
Ruxolitinib (INCB018424) is a JAK1 2 inhibitor (IC50=3.3 2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis.
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TargetMol | Inhibitor Hot
Baricitinib
LY3009104, INCB028050
T24851187594-09-7
Baricitinib (INCB028050) is a JAK1 and JAK2 inhibitor (IC50=5.9 5.7 nM) with selective and oral activity. Baricitinib has potential anti-inflammatory, immunomodulatory and anti-tumor activity.
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TargetMol | Inhibitor Hot
Pyridone 6
Janus-Associated Kinase Inhibitor I, JAK Inhibitor I, JAK I inhibitor, CMP 6
T3080457081-03-7
Pyridone 6 (JAK Inhibitor)(CMP 6) is a potent and selective inhibitor of JAK1 (IC50=15 nM, murine JAK1), JAK2 (IC50=1 nM), JAK3 (Ki=5 nM), and Tyk2 (IC50=1 nM); displaying significantly weaker affinities (130 nM to 10 mM) for other protein tyrosine kinases.
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Pacritinib
SB1518
T6020937272-79-2
Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23 22 nM, in cell-free assays).
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Cerdulatinib hydrochloride
PRT2070 hydrochloride, PRT062070 hydrochloride
T61041369761-01-2
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM 6 nM 8 nM 0.5 nM and 32 nM for JAK1 JAK2 JAK3 TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
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7-10 days
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TargetMol | Inhibitor Sale
Delgocitinib
JTE-052, Corectim(Delgocitinib)
T150961263774-59-9
Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune diseases through JAK-dependent cytokines and can effectively suppress multiple cytokine signaling while inhibiting itching caused by cytokines. It is widely used to treat various inflammatory diseases, including autoimmune diseases and hypersensitivity reactions.
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Baricitinib phosphate
LY-3009104 phosphate, INCB-028050 phosphate, Baricitinib Phosphate
T23601187595-84-1
Baricitinib phosphate (INCB028050) is a selective orally bioavailable JAK1 JAK2 inhibitor.
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Cerdulatinib
PRT2070, PRT062070
T24871198300-79-6
Cerdulatinib (PRT2070) is an novel oral dual Syk JAK inhibitor.
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TargetMol | Inhibitor Sale
Decernotinib
VX-509, VRT-831509
T2636944842-54-0
Decernotinib (VRT-831509)(VX-509; VRT-831509) is a potent and selective Janus kinase 3 (JAK3) inhibitor with Ki of 2.5 nM; IC50 is 50-170 nM in cellular assays.
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TargetMol | Inhibitor Sale
TyK2-IN-2
T132322098466-94-3
TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).
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6-8 weeks
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Tyk2-IN-3
T132331779493-12-7
Tyk2-IN-3 is an inhibitor of Tyk2 pseudokinase (IC50: 485 nM).
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3-6 months
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Tyk2-IN-5
T132341797432-62-2
Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).
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6-8 weeks
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Tyk2-IN-7
T132351609391-90-3
Tyk2-IN-7 is an inhibitor of TYK2 JH2, binds to the TYK2 JH2 domain (IC50: 0.00053 μM; Ki.app: 0.00007 μM).
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6-8 weeks
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Tyk2-IN-9
T132372127109-85-5
Tyk2-IN-9 (Compound 26), a selective Tyk-2 inhibitor, exhibits IC50 values of 0.076 nM for TYK2-JH2 and 1.8 nM for JAK1-JH2, respectively. This specificity makes it suitable for research into inflammatory or autoimmune diseases [1].
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8-10 weeks
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TYK2-IN-11
T616582757009-40-6
TYK2-IN-11 (Compound 5B) is a potent and selective inhibitor of Tyk-2, with IC50 values of 0.016 nM for TYK2-JH2 and 0.31 nM for JAK1-JH2. This compound shows potential for advancing research in inflammatory and autoimmune diseases [1].
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6-8 weeks
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