skin diseases

S-Y048 is an Oxoeicosanoid (OXE) receptor antagonist that inhibits allergen-induced eosinophil infiltration into the skin of experimentally sensitized rhesus monkeys to house dust mites and inhibits lung inflammation caused by aerosolized allergen challenge. S-Y048 can be used to study asthma and other eosinophilic diseases.

Dehydroemetine is an effective antigenic insecticide, which is a synthetic analogue of Emetine dihydrochloride. It can be used to prevent and treat amoeba infections and diseases. It has the effect of treating leishmania infection with skin damage and resistance to metronidazole amoebiosis.

Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.

Bismuth subgallate (Dermatol Puder) is an astringent and antiseptic and is applied to skin diseases such as eczema.

Diflucortolone valerate (Diflucortolone 21-valerate) is a corticosteroid esterified with valeric acid. It helps to reduce itching, redness, and swelling.

Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for the treatment of skin diseases.

Azathioprine (BW 57-322), an immunosuppressive agent, inhibits purine synthesis and GTP-binding protein Rac1 activation.

Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.

1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead

Pradofloxacin is a new generation of fluoroquinolone antibiotics with broad-spectrum antibacterial activity that exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV, preventing the replication and repair of bacterial DNA. Pradofloxacin is mainly used for the treatment of bacterial diseases in dogs and cats including skin infections, urinary tract infections and respiratory tract infections.

BI605906 is an IKKβ inhibitor that inhibits tumor necrosis factor alpha-dependent IkappaB degradation and expression of the pro-inflammatory mediator interleukin-6, which can be used to study inflammatory skin diseases such as psoriasis.

PXS-6302 is an irreversible inhibitor of lysyl oxidase with IC50s of 3.7 μM for Bovine LOX, 3.4 μM for rh LOXL1, 0.4 μM for rh LOXL2, 1.5 μM for rh LOXL3, 0.3 μM for rh LOXL4, respectively. PXS-6302 can readily penetrate the skin, reduces collagen deposition and cross-linking, and significantly improves scar appearance without reducing tissue strength. PXS-6302 also has potentially broader applications in other fibrotic diseases.

LEO 134310, a selective, non-steroidal glucocorticoid receptor (GR) agonist, is optimized for topical treatment. Demonstrating high affinity (EC50 of 14 nM) in GR binding assays, it is suitable for treating skin diseases.

PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2 μM for JAK1, 23.1 μM for JAK2, and 59.9 μM for JAK3, used in the study of lung and skin inflammatory diseases.

Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Orazamide may be useful to treat chronic hepatitis and various skin diseases.

Dexamethasone acetate monohydrate is an adrenocortical steroid. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, asthma, severe allergies, chronic obstructive lung disease, brain swelling, croup, and antibiotics

Elemol (α-Elemol) is a bioactive component extracted from Chamaecyparis obtusa, a fragrance compound with tick repellent properties. It improves skin damage induced by DNCB in mice and can be used for research on skin diseases.

Lepzacitinib is a selective, small molecule JAK1 3 inhibitor used for the treatment of atopic dermatitis and other skin diseases. As a Janus kinase inhibitor, it reduces the inflammatory response.

Tyrosinase-IN-17 (Compound 5b), characterized as a lipophilic, skin-permeable, and non-cytotoxic tyrosinase inhibitor (pIC 50 = 4.99), is suited for research into melanin-related diseases, including melanoma and melanogenesis [1].

Tyrosinase-IN-39 (compound 5r) is a competitive inhibitor of tyrosinase, with an IC50 of 6.4 μM, and is used in the study of skin diseases.

JAK-IN-18 is a potent JAK inhibitor used to study various diseases, particularly those affecting the eyes, skin, and respiratory system.

Acloproxalap is a quinoline-based aldehyde scavenger used in studies of diseases with toxic aldehyde accumulation, including inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, organ diseases, and syndromes associated with viral infections[1] [2].

TRPC4 5-IN-1 can be used for the research of skin inflammatory diseases and proteinuric kidney diseases. TRPC4 5-IN-1 is a potent inhibitor of TRP channel 5 4 (TRPC5 4) with IC50 values of 0.54 μM and 2.06 μM, respectively. [1].