reprogramming — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8987	Epiblastin A		Casein Kinase
	Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs).		Casein Kinase
T21679	4'-bromo-Resveratrol		Sirtuin
	4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)		Sirtuin
T2040	OAC1	BAS 00287861	OCT
	OAC1 (BAS 00287861) is a compound activating Octamer-binding transcription factor 4 (Oct4). It enhances the iPSC reprogramming efficiency and accelerates the reprogramming process.		OCT
T30577	BRD0418	BRD 0418,BRD-0418	Others
	BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.		Others
T83972	NOX-6-18	GPR132 antagonist 1,GPR132-B-160	GPR
	NOX-6-18 (GPR132-B-160) is a highly potent and selective GPR132 antagonist with insulinotropic activity that modulates macrophage reprogramming in pancreatic islets and reduces weight gain.		GPR
T4100	AS8351	NSC51355,AS-8351,AS 8351	Histone Demethylase
	AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblas...		Histone Demethylase
T2019	OAC2		OCT
	OAC2 is an Oct4 activator which activates expression through the Oct4 gene promoter; enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibrobl...		OCT
T3031	A 83-01	ALK5 Inhibitor IV,A8301	ALK , TGF-beta/Smad
	A 83-01 (ALK5 Inhibitor IV) is an inhibitor of the TGF-β type I receptors ALK5, ALK4, and ALK7 (IC50=12/45/7.5 nM). A 83-01 promotes the reprogramming of mouse fibroblasts into iPSCs. A 83-01 can be used in organoid cult...		ALK , TGF-beta/Smad
T24754	Hh-Ag1.5	SAG-1.5,SAG1.5,SAG 1.5	Hedgehog/Smoothened
	Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo. Hh-Ag1.5-mediated reprogramming breaks the quies...		Hedgehog/Smoothened
T60839	SLMP53-1		p53
	SLMP53-1 is a p53 activator with anti-tumor activity, inhibits wt and mutp53, activates reprogramming of glucose metabolism in xenografted human tumor tissues, and interferes with angiogenesis and migration. SLMP53-1 inh...		p53
T8768	MM-102 TFA	HMTase Inhibitor IX TFA	Histone Methyltransferase
	MM-102 TFA (HMTase Inhibitor IX TFA) is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WD...		Histone Methyltransferase
T64066	CSF1R-IN-3		c-Fms , CSF-1R
	CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing ef...		c-Fms , CSF-1R
T77493	Murlentamab	3C23K,GM102	Others
	Murlentamab (GM102) is a humanized anti-AMhRII antibody. Murlentama has potential antitumor activity that induces macrophage-mediated antitumor-dependent cell-mediated cytotoxic effects (ADCC). Murl can stimulate the pro...		Others
T23271	RSC-133		Others
	promotes the reprogramming of human somatic cells to pluripotent stem cells		Others
T24489	MM-401	MM401
	MM-401 is a specific inhibitor of histone H3K4 methyltransferase MLL1 activity that acts by reprogramming mouse epiblast stem cells to naive pluripotency.
T41207	Tocriscreen Stem Cell Library
	The Tocriscreen Stem Cell Library is a bioactive compound library composed of 120 compounds supplied in DMSO (100 μL 10 mM solutions). This compound library contains a diverse range of small molecules to find the best co...
T78751	DG1
	DG1 (Compound 8Nc), a Thymidylate Synthase (TS) inhibitor, impedes angiogenesis and alters metabolic reprogramming in NSCLC cells, while effectively suppressing the expression of CD26, ET-1, FGF-1, and EGF. Additionally,...
T79260	MCI		Reactive Oxygen Species
	MCI, a chemical compound demonstrating significant anti-inflammatory effects, particularly in collagen-induced arthritis (CIA) models, modulates inflammation through macrophage reprogramming by enhancing ROS scavenging a...		Reactive Oxygen Species
T78520	CYT296		Others
	CYT296 is a chromatin de-condensation agent that enhances the efficiency of induced pluripotent stem cell (iPSC) generation mediated by defined factors (OSKM) and promotes an open chromatin state in Mouse Embryonic Fibro...		Others