r-48

FR-48217 is an immunoactive peptide that inhibits multiplication of HSV-1 and HSV-2.

WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency against cruzain with sensitivity to pH conditions and high efficacy in the cell culture assay. Furthermore, WRR-483 also eradicates parasite infection in a mouse model of acute Chagas' disease. WRR-483 binds covalently to the active site cysteine of the protease in a similar manner as other vinyl sulfone-based inhibitors. WRR-483 has potential to be developed as a treatment for Chagas' disease.

HIV-1 inhibitor-48 is a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) and exhibits anti-HIV-1 activity .

ASR-488, an activator of the mRNA-binding protein CPEB1, promotes apoptosis and suppresses the growth of bladder cancer [1].

SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells

Meclinertant (SR 48692) is a neurotensin receptor-1 (NT1) antagonist that blocks neurotensin-induced excitation and can be used to study neurological disorders.

Saredutant (SR 48968) is a selective neurokinin-2 (NK2) receptor antagonist that inhibits the action of neurokinin A by blocking the NK2 receptor, thereby exerting antidepressant and anxiolytic effects.

Tubulin inhibitor 48 (compound 16) is an anticancer agent targeting microtubules. It exhibits IC50 values of 0.1 μM and 0.07 μM against LN-229 and Capan-1 cells, respectively.

HR488B is a potent inhibitor of HDAC1. It specifically hinders the growth of CRC cells by inducing cell cycle arrest at the G0/G1 phase and promoting apoptosis. Furthermore, HR488B leads to mitochondrial dysfunction, the production of reactive oxygen species (ROS), and the accumulation of DNA damage.

OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.

Edaglitazone (R-483) is an orally active, selective and potent PPARγ agonist showing affinity for both PPARα and PPARγ. Edaglitazone displays antiplatelet activity and can be used in studies of diabetes mellitus and obesity.

SR48527 is a selective antagonist of NTS1R.

R 487 is a bioactive chemical.

Famotidine propionic acid is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.

KRAS G12C Inhibitor 48 is a potent inhibitor targeting the KRAS G12C mutation, exhibiting an IC50 value of 639.91 nM. Demonstrating antiproliferative activity, KRAS G12C Inhibitor 48 (0-50 µM) yields IC50 values of 0.796 µM, 6.33 µM, and 16.14 µM against H358, H23, and A549 cell lines, respectively.

Endothelin 1 (swine, human), Alexa Fluor 488-labeled, is a synthetic peptide mirroring human and swine Endothelin 1, an endogenous vasoconstrictor, and is tagged with Alexa Fluor 488 for fluorescence, operating via two receptor types, ET A and ET B [1].

DSPE-Fluor 488 is a phospholipid known for its excellent biocompatibility and distinctive amphiphilic properties, making it an ideal form and excipient in pharmaceutical formulations for enhanced therapeutic outcomes. It is utilized in the study of drug delivery.

DSPE-PEG-Fluor 488, MW 2000 is a PEG-dye-lipid conjugate consisting of DSPE phospholipid and Fluor 488 dye. DSPE is a phospholipid that spontaneously forms micelles in aqueous media, while Fluor 488 is a cyanine dye widely used in fluorescence microscopy with excitation and emission maxima at 499 nm and 520 nm, respectively. Polyethylene glycol lipids are commonly utilized to stabilize lipid nanoparticles.

DSPE-PEG-Fluor 488, MW 5000, is a PEG-dye-lipid conjugate composed of DSPE phospholipid (an unsaturated phospholipid), and Fluor 488 dye (a cyanine dye widely used in fluorescence microscopy with excitation and emission maxima at 499 nm and 520 nm), interconnected by a macromolecular PEG spacer.

DSPE-CH2-PEG-Fluor 488, MW 2000, is a PEG lipid conjugate that includes a DSPE group and the Fluor 488 dye. DSPE is a phosphatidylethanolamine (PE) lipid commonly utilized in liposome synthesis. Fluor 488 serves as a fluorescent dye.

DOPE-PEG-Fluor 488, MW 2000, is a lipid conjugated with polyethylene glycol, featuring a DOPE group and a Fluor 488 fluorescent group. DOPE is an unsaturated phospholipid. Fluor 488 has excitation and emission maxima at 499 nm and 520 nm, respectively.

DOPE-PEG-Fluor 488, MW 5000, is a lipid compound of the PEG class, consisting of a DOPE phospholipid and a Fluor 488 fluorescent dye.

Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor. Duvelisib (R enantiomer) hydrochloride is the less active enantiomer of Duvelisib.

OUP-186 is a high affinity and human/rat species-selective antagonist of histamine H3 receptor. OUP-186 suppressed the proliferation of breast cancer cells. The IC50 values at 48 hours for OUP-186 was approximately 50 μM. OUP-186 potently induced cell dea