progestin

Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.

Norgestimate is an acetylated progestinused in combination with ethinyl estradiol as an oral contraceptive.

TH5427 is a lead NUDT5 inhibitor(MG assay IC50 = 29 nM).

Mifepristone (C-1073) is a progesterone-receptor (IC50=0.2 nM) and glucocorticoid-receptor antagonist (IC50=2.6 nM). Mifepristone is used to terminate pregnancy, treat uterine fibroids, and treat endometriosis.

Medroxyprogesterone Acetate (Farlutin) is a synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.

Levonorgestrel (D-Norgestrel) is a Progestin and Progestin-containing Intrauterine Device. The physiologic effect of levonorgestrel is by means of Inhibit Ovum Fertilization.

17α-Hydroxyprogesterone (17-OHP) is a physiological progestin that is produced during glucocorticoid and steroid hormone synthesis and is increased during the third trimester of pregnancy. Hydroxyprogesterone binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor-mediated gene expression.

Drospirenone (ZK 3059) is a synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity.

Norgestrel (WY-3707) is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes.

16a,17a-Epoxy-4-Pregnen-3,20-Dione is a synthetic progestin, a metabolite of the luteinizing hormone hormone, which acts by binding to the luteinizing hormone receptor. It has been used to study the effects of progesterone on reproductive organs, the effects of the hormone on cell growth and development, and the effects of the hormone on the immune system.

16-Dehydroprogesterone is a endogenous Metabolite. 16-Dehydroprogesterone is a steroidal progestin.

LY88074 analog 1, a benzothiophene compound with nitrogen-containing non-basic side chains, can be utilized either independently or alongside estrogen or progestin. This agent is effective for mitigating post-menopausal symptoms, including osteoporosis, cardiovascular-related pathological conditions, and estrogen-dependent cancer.

Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate) is one of the active metabolites of norgestimate.It is a steroidal progestin used in contraceptive patches, where it is combined with the estrogen ethinyl estradiol.

Norgestomet is a steroidal progestin of the 19-norprogesterone group used in veterinary medicine to control estrus and ovulation in cattle. In addition to the progesterone receptor, norgestomet possesses a weak (micromolar) affinity for the glucocorticoid

Nomegestrol (TX 066 free base) is an orally available, selective and potent full agonist of the progesterone receptor with potent anti-estrogenic, partial anti-androgenic and anti-gonadotropic activity.Nomegestrol is also a contraceptive progestin and is used in the study of endometriosis and meningiomas.

Megestrol is a synthetic progestin exhibiting androgenic, corticosteroid, and progestational properties. It stimulates appetite and is indicated for anorexia and weight loss in patients with acquired immunodeficiency syndrome (AIDS).

Melengestrol is a steroidal progestin of the 17α-hydroxyprogesterone class and also functions as an antineoplastic agent.

Demegestone is a progestin, or a synthetic progestogen, and hence is a progesterone receptor agonist, the biological target of progestogens like progesterone. It has no androgenic activity. Previously used to treat luteal insufficiency.

(+)-Norgestrel is a progestin medication for the treatment of birth control pills and in menopausal hormone therapy.

Cingestol is a steroidal progestin of the 19-nortestosterone group that was never marketed.

Org 2058 is a synthetic progestin.

Promegestone is a progestin medication used in menopausal hormone therapy and in the treatment of gynecological disorders.

Retroprogesterone, a progestin, may be used for menstrual irregularities in adolescence, for the maintenance of threatened pregnancy, and possibly as an ovulation stimulant.

5α-dihydro Levonorgestrel is a metabolite of the synthetic progestin levonorgestrel . It lacks in vitro and in vivo estrogenic activity, but induces copulatory behavior in male rats when administered at a dose of 1 mg per animal per day.