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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4330 | CaCCinh-A01 | Chloride channel | |
CaCCinh-A01 is an inhibitor of the calcium-activated chloride channel (CaCC, 10 μM) and TMEM16A (IC50: 2.1 μM). | |||
T1476 | Pramipexole | SND 919 | Dopamine Receptor |
Pramipexole (SND 919) is a selective dopamine receptor agonist used in the therapy of Parkinson disease. Pramipexole therapy is associated with a low rate of transient serum enzyme elevations during treatment but has not... | |||
T23146 | PHA 568487 free base | PHA 568487 | AChR |
The quinuclidine PHA 568487 free base is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated lia... | |||
T6951 | Pramipexole dihydrochloride hydrate | Pramipexole 2HCl Monohydrate,Mirapex | Dopamine Receptor |
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su... | |||
T2163 | Dihydrocapsaicin | CCRIS1589,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide | Others , TRP/TRPV Channel |
Dihydrocapsaicin (CCRIS1589) is isolated from Capsicum fruit. Capsaicin is the primary active component of the heat and pain-eliciting lipid soluble fraction of the Capsicum pepper. Like capsaicin, dihydrocapsaicin is an... | |||
T27830 | Lifarizine | RS 87476,RS 87476-000,RS-87476,RS-87476-000,RS87476 | Calcium Channel |
Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion. | |||
T24873 | TGX-115 | TGX 115 | PI3K |
TGX-115 is a cell-permeable and potent inhibitor of the PI 3-K isoform p110β/p110δ (IC50 values of 0.13 μM for p110β and 0.63 μM for p110δ), an enzyme that regulates platelet adhesion and inhibits phosphoinositide (PI) 3... | |||
T11994 | Melagatran | Thrombin | |
Melagatran, a direct and orally active thrombin inhibitor, specifically inhibits thrombin without affecting other enzymes in the coagulation cascade or fibrinolytic enzymes. It does not rely on endogenous co-factors to e... | |||
T70540 | Pinokalant | LOE-908 | SARS-CoV , TRP/TRPV Channel |
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem... | |||
T35689 | MTP 131 acetate | Others | |
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... | |||
T16902 | SMND-309 | Others | |
SMND-309 is a metabolite of salvianolic acid B. It also shows neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats. | |||
T68814 | GZN39838 | ||
GZN39838, also known as 6beta-Acetoxy-7alpha-hydroxyroyleanone is a natural blocker of Kv1.2 channels, not involving direct occlusion of the outer pore but depending on C-type inactivation. | |||
T27897 | LY 215490 | LY215490,LY-215490 | |
LY 215490 is a selective, competitive and systemically active antagonist of AMPA receptor. LY 215490 has neuroprotective effect against focal ischaemia in a model of permanent MCA occlusion in the rat. | |||
T41029 | Streptokinase | ||
Streptokinase is a bacterial protein that acts as a plasminogen activator, commonly employed in the investigation of blood-clotting disorders. Its application extends to enhancing reperfusion blood flow after coronary ar... | |||
T27351 | Fostedil | KB-944,KB944,A 53986,KB 944,A-53986,BRN 3626546 | |
Fostedil is a calcium channel antagonist. KB-944 increased regional segment function in normal and ischemic regions and maintained distal coronary artery perfusion pressure, coronary flow and transmural regional myocardi... | |||
T76987 | Tarcocimab | ||
Tarcocimab (OG1953), a humanized IgG1-type anti-VEGFA monoclonal antibody, is utilized in research targeting conditions such as retinal vein occlusion (RVO) and wet age-related macular degeneration (AMD). | |||
T81455 | Piridoxilate | Piridoxylate | |
Piridoxilate, a glyoxylate derivative, functions as an anti-anoxic agent and serves research purposes, particularly in the study of vascular diseases and coronary occlusion [1] [2]. | |||
T28414 | Piclozotan | SUN-N-4057,SUN4057,SUNN-4057,SUN-4057,SUNN4057 | 5-HT Receptor |
Piclozotan (anhydrous), a 5-HT1A receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-MCAO) model, ameliorating motor complications in patients with advan... | |||
T83730 | Tat-M2NX TFA | ||
Tat-M2NX, a peptide antagonist of transient receptor potential melastatin 2 (TRPM2), blocks hydrogen peroxide-induced calcium influx in HEK293 cells expressing human TRPM2 at concentrations between 25 to 100 µM. In male ... | |||
T36570 | KUS121 | ||
KUS121 is a valosin-containing protein (VCP) modulator that inhibits VCP ATPase activity (IC50= 330 nM).1It inhibits cell death, ATP depletion, and upregulation of C/EBP-homologous protein (CHOP) induced by tunicamycin, ... |