ob-1

OB-1 is a protein-like protein-3 (STOML3) inhibitor, inhibiting adipogenesis and lipid droplet growth by downregulating the PPARγ pathway. OB-1 inhibits adipogenesis and lipid droplet growth by interfering with the self-association of stomatin.

COB-187 is an effective, ATP-competitive, selective inhibitor of GSK-3β. It inhibits GSK-3 through a reversible, cysteine (Cys)-199 dependent mechanism. Additionally, COB-187 suppresses the production of cytokines induced by LPS and the production of CXCL10 triggered by the SARS-CoV-2 spike protein.

OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferationin vitroand PCA tumor growth and lymph node/lung metastasesin vivo. Synergizes with Taxol.

Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.

Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.

OB-24 free base is a potent and selective heme oxygenase 1 (HO-1) inhibitor.

Gastric inhibitory peptide 1 (GIP-1) (3-42), a fragment of the incretin hormone GIP and antagonist to the GIP receptor, is generated through the action of serum dipeptidyl peptidase 4 (DDP-4). When administered at 25 nmol/kg to an ob/ob mouse diabetes model, GIP-1 (3-42) elevates plasma glucose levels and lowers plasma insulin levels, demonstrating its effect on reducing insulin secretion from BRIN-BD11 pancreatic cells at a concentration of 100 nM.