ob-1

OB-1 is a protein-like protein-3 (STOML3) inhibitor, inhibiting adipogenesis and lipid droplet growth by downregulating the PPARγ pathway. OB-1 inhibits adipogenesis and lipid droplet growth by interfering with the self-association of stomatin.

1,2-Bis(4-(benzo[d]oxazol-2-yl)phenyl)ethene (Standard) is the standard substance of 1,2-Bis(4-(benzo[d]oxazol-2-yl)phenyl)ethene, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. 1,2-Bis(4-(benzo[d]oxazol-2-yl)phenyl)ethene is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

COB-187 is an effective, ATP-competitive, selective inhibitor of GSK-3β. It inhibits GSK-3 through a reversible, cysteine (Cys)-199 dependent mechanism. Additionally, COB-187 suppresses the production of cytokines induced by LPS and the production of CXCL10 triggered by the SARS-CoV-2 spike protein.

SNOB 1 Reagent is a biotinylated probe for detecting S-nitrosylated proteins in a single step. S-Nitrosylated binding (SNOB) proceeds rapidly on surface proteins or cell lysates under normal physiological conditions. Proteins tagged with SNOB 1 Reagent can be analyzed using avidin-linked probes (e.g., by immunoblot) or by mass spectrometry.

(2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one is a useful organic compound for research related to life sciences. The catalog number is T65968 and the CAS number is 42399-49-5.

COB1 pheromone, a bacterial sex pheromone, effectively inhibits the multidrug-resistant Enterococcus faecalis V583 [1].

Anti-Mouse 4-1BB/CD137 (LALA-PG) Antibody (LOB12.3) is an IgG2a, κ agonistic antibody derived from mice, specifically targeting mouse 4-1BB/CD137.

The Anti-Mouse4-1BB/CD137 Antibody (LOB12.3) is a mouse-derived antibody characterized by its rat IgG1 kappa isotype and specifically targets 4-1BB/CD137. Its isotype control is the Rat IgG1 kappa, Isotype Control.

OB 24 hydrochloride is a potent and selective heme oxygenase 1 (HO-1) inhibitor (IC50 values are 1.9 and >100 μM for HO-1 and HO-2 respectively), reduces protein carbonylation and reactive oxygen species formation in advanced prostate cancer cells (PCA). Inhibits cell proliferationin vitroand PCA tumor growth and lymph node/lung metastasesin vivo. Synergizes with Taxol.

Phanginin A, a natural product discovered in Caesalpinia sappan Linn, activates SIK1 and inhibits gluconeogenesis in mouse primary hepatocytes. Phanginin A increases PDE4 activity and suppresses the hepatic cAMP/PKA/CREB pathway, improving metabolic disorders in ob/ob mice. It may be used in studies of type 2 diabetes.

OB-24 free base is a potent and selective heme oxygenase 1 (HO-1) inhibitor.

Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.

Gastric inhibitory peptide 1 (GIP-1) (3-42), a fragment of the incretin hormone GIP and antagonist to the GIP receptor, is generated through the action of serum dipeptidyl peptidase 4 (DDP-4). When administered at 25 nmol/kg to an ob/ob mouse diabetes model, GIP-1 (3-42) elevates plasma glucose levels and lowers plasma insulin levels, demonstrating its effect on reducing insulin secretion from BRIN-BD11 pancreatic cells at a concentration of 100 nM.

Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.