non-catalytic — TargetMol Chemicals

Search Result

Search Results for " non-catalytic "

Compounds

Cat No.	Product Name	Synonyms	Targets
T9884	EN523		Others
	EN523 targets non-catalytic allosteric cysteine C23 in K48 ubiquitin-specific deuquitinase OTUB1.		Others
T16333	NKY80	Adenylyl cyclase type V Inhibitor	Adenylyl cyclase
	NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respe...		Adenylyl cyclase
T5461	GNE-6640		DUB
	GNE-6640 is a non-covalent inhibitor targeting ubiquitin specific peptidase 7 (USP7), exhibiting IC50 values of 0.75 μM for full-length USP7, 0.43 μM for the USP7 catalytic domain, 20.3 μM for full-length USP43, and 0.23...		DUB
T11552	HDDAH-1-IN-1		Others
	hDDAH-1-IN-1 is a selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) (Ki: 18 μM).		Others
T12621L	FT671		DUB
	FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).		DUB
T11552L	HDDAH-1-IN-1 TFA		Others
	hDDAH-1-IN-1 TFA is a selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) (Ki: 18 μM).		Others
T26827	Bisnorcymserine	N1 N8 Bisnorcymserine,N1N8Bisnorcymserine,N1-N8-Bisnorcymserine
	Bisnorcymserine is a reversible inhibitor of butyrylcholinesterase. The leaving group, bisnoreseroline, interacts in a non-covalent way with Ser(200) and His(440), disrupting the existing interactions within the catalyti...
T13737	IRucaparib-AP6		Others
	iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC ...		Others
T70810	THR-18
	THR-18 is an 18-mer peptide derived from the sequence of human plasminogen activator inhibitor 1 (PAI-1), having the ability to bind to a site of tissue plasminogen activator (tPA) distal to its catalytic site and uncoup...
T76149	Formate dehydrogenase
	Formate dehydrogenase, a widely present enzyme in both prokaryotes and eukaryotes, facilitates the reversible oxidation of formate to carbon dioxide. Based on its metal content, structure, and catalytic approach, it is c...
T74638	XL01126
	XL01126, a potent degrader of LRRK2, exhibits DC50 values of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. It has the ability to cross the blood-brain barrier, making it a viable degrader probe for Parkinson’s...
T82079	IGRP(206-214)
	IGRP(206-214) is an bioactive peptide corresponding to residues 206–214 of the murine islet-specific glucose-6-phosphatase catalytic subunit–related protein (IGRP). It induces diabetes in non-obese diabetic (NOD) mice by...
T74174	JB170
	JB170, a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM), achieves its selectivity by linking Alisertib to the Cereblon-binding molecule Thalidomide. It demonstrates a strong pre...