nicotine

CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist with pEC50 values of 9.96 for human 5-HT2C, 7.19 for 5-HT2B, and 6.81 for 5-HT2A receptors.

AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

Nicotinic receptor agonist

Nicotine is a naturally produced alkaloid in the nightshade family of plants (most predominantly in tobacco and Duboisia hopwoodii) and is widely used recreationally as a stimulant and anxiolytic. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits (nAChRα9 and nAChRα10) where it acts as a receptor antagonist.

(2'S)-Nicotine-1-oxide, a nicotine metabolite, arises from the liver's metabolism of nicotine via the cytochrome P450 (CYP) isoform CYP2A6. It has been identified in human sperm and semen.

Nicotine 1'-N-oxide ((1′S,2′S)-Nicotine-1'-oxide) is a derivative of nicotine obtained from tobacco smoke condensate.

α-Nicotine is an α-isomer of nicotine. Nicotine acts as an agonist of nicotinic acetylcholine receptors (nAChR) and holds potential for research in neuropsychiatric disorders such as schizophrenia and ADHD.

(+/-)-NICOTINE-D4 is a deuterated compound of (+/-)-NICOTINE.

(1'S,2'S)-Nicotine-1'-Oxide-D3 is a deuterated compound of  (1'S,2'S)-Nicotine-1'-Oxide (TN4655). (1'S,2'S)-Nicotine-1'-Oxide has a CAS number of 51095-86-4. Nicotine 1'-N-oxide is a natural product from tobacco smoke.

Nicotine-[13C,D3], Racemic Mixture (Standard) is a reference standard of Nicotine-[13C,D3], Racemic Mixture intended for quantitative analysis, quality control, and related biochemical research applications.

(+/-)-Nicotine-D4 (Standard) is a reference standard of (+/-)-Nicotine-D4 intended for quantitative analysis, quality control, and related biochemical research applications. (+/-)-NICOTINE-d4 is a deuterated compound of (+/-)-NICOTINE.

NNK is a nitrosated derivative of nicotine that activates the ERK1/2 and PKCα signaling pathways, induces Bcl2 phosphorylation at Ser70, and activates c-Myc at Thr58 and Ser62, thereby promoting the proliferation and survival of human lung cancer cells, and is commonly used to establish lung cancer mouse models.

beta-Nicotyrine is a tobacco alkaloids Metabolite in the liver.

Varenicline dihydrochloride is a Selective α4β2 nicotinic acetylcholine receptor partial agonist.

Pelanserin Free Base is an antagonist of the 5-HT2 and α1-adrenergic receptors.

SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM

(Z)-Metanicotine 2HCl has analgesic activity and is used in the treatment of central system disorders.

(±)-Nornicotine ,with CAS No. 5746-86-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (±)-Nornicotine provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

N-Formylnornicotine (Compound 2) is a pivotal intermediate in the conversion of Nornicotine into nicotine.

N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.

N'-Nitrosonornicotine is a tobacco-specific N-nitrosamine and carcinogen that has been found in unburned tobacco and cigarette smoke.1It induces the formation of DNA adducts in isolated rat nasal mucosa and esophagus. N'-Nitrosonornicotine induces tumor formation in rat esophagus and nasal cavity, mouse lung, forestomach, and trachea, and hamster trachea and forebrain. Urinary levels of N'-nitrosonornicotine are positively correlated with the risk of esophageal cancer in smokers.2 1.Hecht, S.S.Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosaminesChem. Res. Toxicol.11(6)559-603(1998) 2.Yuan, J.-M., Knezevich, A.D., Wang, R., et al.Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokersCarcinogenesis32(9)1366-1371(2011)

Metanicotine is a selective nicotinic agonist with antinociceptive properties.

N′-Nitrosonornicotine N-glucuronide is a biochemical reagent utilized in glycobiology research. This field examines the structure, synthesis, biology, and evolution of sugars, encompassing carbohydrate chemistry, glycoconjugate formation and degradation enzymology, protein-glycan recognition, and the roles of glycans in biological systems. It is intimately connected with fundamental research, biomedicine, and biotechnology.

UB 165 fumarate is an agonist of the nAChR, a partial agonist of the α4β2 subtype, and a full agonist of the α3β2 subtype, with a Ki value of 0.27 nM for binding to [3H]-nicotine measured in rat brain.