nanoparticle

1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is a cylindrical-shaped lipid used to synthesize liposomes. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (L-ALPHA-PHOSPHATIDYLCHOLINE, DISTEAROYL) is the lipid component in the lipid nanoparticle (LNP) system.

SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines.

N,N'-Dicyclohexylurea (AURORA KA-3582) is a soluble epoxide hydrolase (sEH) inhibitor.

DMG-PEG 2000 (DMG-PEG2000) can be used for the preparation of lipid nanoparticles for the in vivo delivery of plasmid DNA via oral administration, enhancing the mucosal permeability and delivery efficiency of the nanoparticles. DMG-PEG 2000 can be used for the preparation of liposomes for siRNA transfection, improving transfection efficiency.

PLGA nanoparticles, 100 nm, are nanocarriers composed of the polymer PLGA, which can be utilized for drug delivery.

PLGA nanoparticles, 500 nm, are nanoscale particles composed of the polymer PLGA, utilized in drug delivery systems.

PLGA nanoparticles (500 nm) are polymer-based particles made from PLGA, utilized for drug delivery.

PLGA nanoparticles, measuring 1μm, are polymer-based particles crafted from PLGA, suitable for drug delivery applications.

C12-200 is a five-tail/branched ionizable cationic lipid that serves as a benchmark lipid material in RNA delivery, demonstrating exceptional performance in mRNA and siRNA lipid nanoparticle (LNP) formulations.

ALC-0315 is an ionizable cationic lipid that serves as a core component of lipid nanoparticle (LNP) delivery systems for mRNA vaccines, responsible for efficiently encapsulating, protecting, and delivering nucleic acids into cells. Lipid nanoparticles have already been used in research on mRNA (COVID-19) vaccines.

IR820-PTX is a nanoparticle composed of IR-820 and paclitaxel that is highly permeable and tumor-targeting.IR820-PTX can be used for near-infrared fluorescence imaging and tumor diagnostics.9-cis-Retinoic Acetylcholine (RAC) is a nanoparticle that is highly permeable and tumor-targeting.

Maleimide (2,5-Pyrroledione) (2,5-Pyrroledone) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions.

DL-Alanine (DL-2-Aminopropionic acid) is an amino acid that is a racemic compound of L- and D-alanine.DL-Alanine is often used as a reducing and capping agent in conjunction with aqueous silver nitrate for nanoparticle generation.DL-Alanine is a sweetening agent, and can be grouped with glycine and sodium saccharin.DL-Alanine plays an important role in glucose-alanine cycling between tissues and liver.DL-Alanine can be used to study the chelation of transition metals such as Cu, Zn, and Cd. DL-Alanine plays an important role in the glucose-alanine cycle between tissues and the liver.DL-Alanine can be used to study the chelation of transition metals such as Cu, Zn, and Cd.

Lipoamido-PEG3-OH, also known as compound TA-TEG-G2CN, is a PEG-based PROTAC linker utilized in PROTAC synthesis. It is instrumental in the creation of a robust, dendronized gold nanoparticle (AuNP)-based drug delivery platform[1].

Cholesteryl oleate (Cholesteryl cis-9-octadecenoate) is a cholesteryl ester. Cholesteryl oleate can be used to synthesize solid lipid nanoparticles which is a nanoparticle-based gene therapy approach.

eGFP mRNA-LNP (500 ng/uL) is a lipid nanoparticle (LNP) containing eGFP mRNA, suitable for assays of RNA delivery, translation efficiency, and cell viability. eGFP circRNA includes the Enhanced Green Fluorescent Protein (eGFP), which expresses green fluorescent protein upon entering cells. eGFP is commonly used as a reporter gene detectable by fluorescence microscopy or flow cytometry.

Antimicrobial agent-36 (Compound 8b) is an antimicrobial compound that significantly inhibits DNA gyrase with an IC50 value of 4.56 µM. It is also utilized in the preparation of nanoparticle drug formulations and can be employed in the research and development of new antibiotics.

18:1 PE (DOPE) pSar25 is a derivative of polyethylene glycol, suitable for use in liposome and lipid nanoparticle delivery systems.

Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.

ALN-3133 sodium is a siRNA targeting VEGF and is one of the siRNAs in ALN-VSP. ALN-VSP is a lipid nanoparticle formulation containing two siRNAs against kinesin spindle protein (KSP) and VEGF, offering potential antitumor activity.

ALN-12115 sodium is a siRNA targeting the microtubule motor protein (KSP) and is one of the siRNAs in ALN-VSP. ALN-VSP is a lipid nanoparticle formulation containing two siRNAs that target KSP and VEGF, offering potential antitumor activity.

ALN-12115 is an siRNA targeting the microtubule motor protein (KSP) and is part of ALN-VSP, a lipid nanoparticle formulation containing two siRNAs aimed at KSP and VEGF, with potential antitumor activity.

Budesonideoleate (C18:1) (Budesonide 21-oleate) is a prodrug of Budesonide, serving as an active ingredient in anti-inflammatory lipid nanoparticles for the targeted delivery of anti-inflammatory formulations.

Dimethyldioctadecylammonium bromide is a synthetic double-chain cationic lipid composed of a positively charged quaternary ammonium headgroup and two long-chain hydrophobic alkyl groups. It is capable of self-assembling into liposomes and nanoparticle systems and is commonly used in gene delivery and vaccine adjuvant development, where it promotes cellular uptake by forming complexes with nucleic acids; It also has applications as a surfactant and emulsifier.