mip-1β

Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction.

Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.

TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).

TLR4 agonist-1 (TEA, compound 17a) is a potent activator of Toll-like Receptor 4 (TLR4) and prompts the production of MIP-1β in RAW 264.7 and MM6 cells [1].

TLR4 agonist-1 (compound 17a) is a potent activator of Toll-like Receptor 4 (TLR4), stimulating MIP-1β production in RAW 264.7 and MM6 cells [1].

BC-1293 is an inhibitor of the E3 ligase subunit FBXO24. It disrupts the interaction between FBXO24 and aspartyl-tRNA synthetase (DARS2), enhancing DARS2 levels. Additionally, BC-1293 increases levels of IL-1β, IL-9, MIP-2, and TNF α, demonstrating immunostimulatory activity in mice.