m 17

M 17 is a bioactive chemical.

Anti-Mouse CD11a/LFA-1α Antibody (M17/4) is a rat IgG2a kappa monoclonal antibody specifically targeting CD11a/LFA-1α in mouse models. The recommended isotype control for this antibody is 'Rat IgG2a kappa, Isotype Control'.

Pomalidomide-5-OH is the primary active metabolite of pomalidomide. Pomalidomide-5-OH acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN) and can be used to recruit the cereblon protein. Pomalidomide-5-OH can be linked to a protein ligand via a linker to form a PROTAC.

m-PEG17-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

m-PEG17-Hydrazide is a PEG-based linker for PROTACs, essential for joining two ligands to form PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

m-PEG17-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

U-[13C17]-Aflatoxin M2 in Acetonitrile (Standard) is a fully 13C isotope-labeled aflatoxin M2 solution that can be used as an analytical standard for the determination of aflatoxin M2 in samples.

IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM.

Antibiotic OM 173?2 is a useful organic compound for research related to life sciences. The catalog number is T124003 and the CAS number is 88293-10-1.

Bam 1745 is a significant adrenomedullary secretory vesicles component.

M 1704 is a bioactive chemical.

Sodium 17β-Estradiol-2,4,16,16-[D4] 3-Sulfate (Standard) is a reference standard of Sodium 17β-Estradiol-2,4,16,16-[D4] 3-Sulfate intended for quantitative analysis, quality control, and related biochemical research applications.

Sodium 17β-Estradiol-16,16,17-[D3] 3-Glucuronide (Standard) is a reference standard of Sodium 17β-Estradiol-16,16,17-[D3] 3-Glucuronide intended for quantitative analysis, quality control, and related biochemical research applications.

C-176 (STING inhibitor 1) is a STING inhibitor with selectivity and blood-brain barrier permeability. C-176 inhibits STING-mediated IFNβ production and possesses anti-inflammatory activity.

H-151 is a highly potent and selective STING antagonist. H-151 covalently binds to Cys91 of STING and inhibits palmitoylation of Cys91, thereby inhibiting STING activity. H-151 can be used in the study of autoinflammatory diseases in vivo and ex vivo.

Vadimezan (DMXAA) is a vascular disrupting agent, a murine STING agonist, and an inducer of cytokines such as type I IFN. Vadimezan has antitumor activity and induces a rapid cessation of blood flow in tumors without affecting blood flow in normal tissues.

Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

MSA-2 is an orally available non-nucleotide STING agonist. The non-covalent dimer of MSA-2 binds to STING with nanomolar affinity. It shows anti-tumor activity in syngeneic mouse tumor models, synergizes with anti-PD-1, stimulates tumor secretion of interferon-β, induces tumor regression, and has long-lasting anti-tumor immunity. [3]

SN-011 (GUN35901) is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.

IK-862 is a selective inhibitor of TACE (ADAM17).

INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.

JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.

K-111 (BM-170744) is an orally available peroxisome proliferator-activated receptor (PPAR)-alpha agonist and insulin enhancer for the study of obesity-type diabetes mellitus and the metabolic syndrome.

diABZI STING agonist-1 (trihydrochloride) is a stimulator of interferon genes (STING) receptor agonist.