laminin

Laminin 925-933 is a peptide originating from residues 925-933 of the laminin B1 chain, known for its binding affinity to the laminin receptor.

Laminin (925-933) acetate is derived from the Laminin B1 chain that binds to the laminin receptor.

Laminin β2 (Engelbreth-Holm-Swarm murine sarcoma basement membrane) is a crucial structural component in animal tissues, forming part of the framework that supports tissue architecture. It interacts with type IV collagen through entactin and basement membrane proteoglycans and associates with cell membranes via integrin receptors, dystroglycan complexes, and Lutheran blood group glycoproteins. Additionally, it contains functional domains that facilitate collagen binding, cell adhesion, heparin interactions, and promote neurite outgrowth.

PA22-2 (free acid) (Cys-Laminin A chain 2091-2108), a peptide, promotes neurite outgrowth and facilitates the formation of neuron-like processes. It is used in the culturing of human adenoid cystic carcinoma cells and the development of peptide-functionalized supported phospholipid bilayers [1] [2] [3].

PA22-2, an active biological peptide featuring the IKVAV sequence from the laminin A-chain fragment, is derived from mouse laminin alpha1 amino acid residues 2110-2127. Substrates composed of PA22-2 have been shown to facilitate neurite outgrowth.

YIGSR is a peptide that inhibits tumor growth and metastasis of leukemic cells [1].

Laminin (925-933) (TFA) is a peptide corresponding to the 925-933 sequence of the Laminin B1 chain, known to bind the laminin receptor [1].

Laminin Penta Peptide, amide is a polypeptide molecule with the sequence YIGSR-NH2.

Laminin B1 (1363-1383) is the Residue 1363-1383 of the laminin B1 chain.

Laminin (925-933) (TFA) is a peptide derived from residues 925-933 of the Laminin B1 chain that binds to the laminin receptor.

Laminin B1 octapeptide P-8 is a synthetic laminin B1 chain octapeptide with laminin receptor binding ability.

Mouse Laminin is a laminin protein derived from mice, utilized as a thin coating for tissue culture surfaces or as a soluble additive in culture media.

Human Laminin, derived from rats, is a protein that can be utilized as a thin layer coating for tissue culture surfaces or as a soluble additive in culture media.

Rat Laminin is a laminin protein derived from rats that can be utilized as a thin layer coating for tissue culture surfaces or as a soluble additive in culture media.

Thialaminine is a type of strongly basic chemical modification of cysteine.

safironil is a novel antifibrotic compound and a competitive inhibitor of collagen synthesis. safironil inhibited in vitro experiments on fibroblast activation monitored by collagen I mRNA or smooth muscle alpha-actin levels, and fibrogenesis as judged by type I and type III collagen and laminin production. safironil had no effect on the size of liver granulomas without altering total hydroxyproline, but altered the pattern of fibrosis by increasing type III and decreasing type I collagen deposition.

Hexapeptide-10 Acetate (Hexapeptide-10 Acetate) is a synthetic peptide. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin restructuring and firming abilities.

Palmitoyl Tripeptide-38 Acetate (Palmitoyl Tripeptide-38 Acetate (1447824-23-8 Free base)) , consisting of three amino acids, is a di-oxidized lipopeptide. The peptide was inspired by a tripeptide that occurs naturally in collagen VI and laminin. It rebuilds the skin from the inside where it is needed, smoothes wrinkles and soothes the skin, especially for forehead lines, crow's feet, forehead lines and necklines.

Lysoganglioside-GM1 (LysoGM1) ammonium is a derivative of Monosialoganglioside GM1, lacking the fatty acid component. It serves as an inhibitor of GM1 aggregation and can also inhibit the activation of Lyn as well as neurite outgrowth mediated by laminin-1. Lysoganglioside-GM1 ammonium is utilized in research on neurological disorders.

NSC47924, a laminin receptor (LR) inhibitor, effectively interferes with the binding interactions of LR, potentially impeding the receptor's role in cell adhesion and signaling pathways.

Cytostatin (sodium salt) is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin (sodium salt) potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.

Cytostatin is a natural antitumor inhibitor of cell adhesion to extracellular matrix, blocking adhesion of B16 melanoma cells to laminin and collagen type IV in vitro (IC50s = 1.3 and 1.4 μg/ml, respectively) and B16 cells metastatic activity in mice. It induces apoptosis of FS3 mouse fibrosarcoma cells (IC50 = 3.1 μg/ml). Cytostatin potently and selectively inhibits protein phosphatase 2A (PP2A; IC50 = 29 nM against the catalytic subunit), while having no effect against PP1, PP2B, or PP5.

H-Ile-Lys-Val-Ala-Val-OH (IKVAV) is a short peptide with a sequence length of 5, present in the extracellular matrix (ECM), on the α-laminin chain. H-Ile-Lys-Val-Ala-Val-OH participates in a variety of life activities, such as promoting cell adhesion, neurite outgrowth, angiogenesis, collagenase IV production and tumor growth. H-Ile-Lys-Val-Ala-Val-OH can induce rapid differentiation of neural progenitor cells into neurons and neurite outgrowth.

α7β1 integrin modulator-1 is an α7β1 integrin activator. It upregulates α7 integrin expression and enhances laminin binding, utilized in Duchenne Muscular Dystrophy (DMD) research.