imp1

BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association

IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.IMP-1710 has antifibrotic activity. [1]

Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.

Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.

IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.

BLIMP-1 ligand-1 (Compound 9) is a ligand for BLIMP-1 with a Kd value of 0.06 μM. It serves as a ligand for target proteins in the development of PROTAC BLIMP-1 degraders, such as PROTAC BLIMP-1 degrader-1, and is applicable in the study of multiple myeloma.

BLIMP-1 ligand-Linker Conjugate 1 is a conjugate consisting of BLIMP-1 ligand-1 and a linker. It has the capability to combine with CRBN ligand-881 to form PROTACBLIMP-1 degrader-1.

PROTACBLIMP-1 degrader-1 (Compound 49) is a BLIMP-1 PROTAC degrader. It facilitates the ubiquitination and degradation of BLIMP-1 and is applicable in research related to myeloproliferative neoplasms.

IMP-1700 is an inhibitor of bacterial DNA repair.1It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistantS. aureus(MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active againstE. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8 μM, respectively). 1.Lim, C.S.Q., Ha, K.P., Clarke, R.S., et al.Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureusBioorg. Med. Chem.27(20)114962(2019)

MK-3402, a metallo-beta-lactamase inhibitor, is used in bacterial research.

Metallo-β-lactamase-IN-15 (Compound ±13), a potent inhibitor of MBL, demonstrates IC 50 values of 0.29 μM for NDM-1, 0.088 μM for IMP-1, and 0.063 μM for VIM-2, respectively [1].

MYX1715 is an inhibitor of N-myristoyltransferase (NMT) with a KD value of 0.09 nM. MYX1715 inhibits the proliferation of LU0884 and LU2511 cells with IC50 values of 44 nM and 9 nM, respectively. In mouse models, MYX1715 demonstrates antitumor activity against neuroblastoma and gastric cancer. Additionally, MYX1715 can be utilized as a toxin component in antibody-drug conjugates (ADCs). The potent N-myristoyltransferase inhibitory activity of MYX1715 supports the application of MYX1715 in cancer biology research, protein lipidation studies, targeted delivery platform development, and investigations of N-myristoyltransferase-dependent cellular processes.

IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.

Inosinic acid-13C5 (5'-IMP-13C5) TEA is a 13C-labeled version of inosinic acid. It is an endogenous metabolite commonly used as a food flavor enhancer and as a feed supplement to improve the yield and quality of pork.