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Results for "

ifn-a-1

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    65
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    6
    TargetMol | Peptide_Products
  • Inhibitory Antibodies
    4
    TargetMol | Inhibitory_Antibodies
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    TargetMol | PROTAC
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    39
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    TargetMol | Inhibitors_Agonists
TargetMolTargetMolCompare
IFN-alpha 1/IFNA1 Protein, Mouse, Recombinant (hFc)
LeIF D, Interferon α-D, Interferon α-1 13, Interferon α1, Interferon alpha-D, Interferon alpha-1 13, Interferon alpha 1, IFN-α-1 13, IFN-α-1, IFNα1, IFN-alpha-1 13, IFN-alpha-1, IFNalpha 1, IFNA1, IFN α1, IFN α 1, IFN alpha1
TMPK-00074
IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1 IFNA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.88 kDa and the accession number is P01572.
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7-10 days
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SPR-compatible buffer
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STAT1 Protein, Human, Recombinant
Transcription Factor ISGF-3 Components p91 p84, STAT1, Signal Transducer and Activator of Transcription 1-α β, Signal Transducer and Activator of Transcription 1-α Beta, Signal Transducer and Activator of Transcription 1-Alpha Beta
TMPJ-00961
Signal Transducer and Activator of Transcription 1-Alpha Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.
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7-10 days
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SPR-compatible buffer
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IFN-omega Protein, Bovine, Recombinant (His & SUMO)
Interferon omega-1, Interferon alpha-II-1, IFNW1, IFNW, IFN-omega-c1
TMPH-00277
Expression system: E. coli
Length: 24-195, Full Length of Mature Protein
Activity: Not Tested
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20 days
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Buffer-exchangeable
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IRF1 Protein, Human, Recombinant (GST & His)
IRF-1, IRF1, Interferon regulatory factor 1
TMPH-01552
Expression system: Baculovirus Insect Cells
Length: 1-325, Full Length
Activity: Not Tested
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20 days
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Buffer-exchangeable
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Influenza A H1N1 (strain A/Malaysia:Malaya/302/1954) Non-structural protein 1 (His & Myc)
NS1A, NS1, NS, Non-structural protein 1
TMPH-02349
Expression system: E. coli
Length: 1-237, Full Length
Activity: Not Tested
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20 days
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Buffer-exchangeable
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IL-18BP Protein, Human, Recombinant (hFc)
Tadekinig-alfa and IL18BP, Interleukin-18-binding protein
TMPJ-00074
Interleukin-18-binding protein, also known as Tadekinig-alfa and IL18BP, contains 1 Ig-like C2-type domain. IL18BP is constitutively expressed and secreted in mononuclear cells. IL18BP functions as an IL18 inhibitor. IL18BP binds to IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production. It has been shown that IL18BP may be a promising molecular approach to inhibit neointimal hyperplasia and arteriosclerosis progression following coronary and peripheral angioplasty.
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7-10 days
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SPR-compatible buffer
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PD-1 Protein, Human, Recombinant (His & Avi), Biotinylated
Programmed cell death protein 1, PDCD1, hPD-1, CD279
TMPJ-00181
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28 CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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IFNAR1 Protein, Rhesus macaque, Recombinant (His)
β-type antiviral protein, α-type antiviral protein, IFN-α β receptor 1, IFN-α β R1, IFN-alpha beta receptor 1, IFN-alpha beta R1, IFN-al, human interferon-α receptor (HuIFN-α-Rec)10IFRC, human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, beta-type antiviral protein, AVP, alpha-type antiviral protein
TMPJ-00331
Interferon‑alpha beta receptor 1 (IFN‑ alpha beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
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7-10 days
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SPR-compatible buffer
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VCAM-1 Protein, Mouse, Recombinant (hFc)
Vcam1, Vascular cell adhesion protein 1
TMPJ-00930
Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interacts with integrin alpha-4 beta-1 (ITGA4 ITGB1) on leukocytes, and mediates both adhesion and signal transduction.
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7-10 days
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SPR-compatible buffer
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IL-18 Protein, Mouse, Recombinant (His)
Interferon γ-inducing factor, Interleukin-1 gamma, Igif, IL-1 gamma, Interleukin-1 γ, IL-1 γ, Interferon gamma-inducing factor, Il18, IFN-γ-inducing factor, IFN-gamma-inducing factor, Interleukin-18
TMPJ-01056
Interleukin-18 (IL-18)is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs. It augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8+ T cells and NK cells. In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils.
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7-10 days
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IL-21R Protein, Mouse, Recombinant (aa 20-236, His)
Nilr, Interleukin-21 receptor, IL-21R, Il21r, IL-21 receptor
TMPJ-01337
Expression system: HEK293 Cells
Length: 20-236, Partial
Activity: Not Tested
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7-10 days
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SPR-compatible buffer
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SARS-CoV-2 NSP1 Protein (His)
SARS-CoV 2 nsp1, SARS-CoV 2 Leader protein
TMPJ-01425
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.
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7-10 days
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B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi)
UNQ309, PSEC0249, PRO352, CD276, B7-H3, B7 homolog 3,  4Ig-B7-H3
TMPK-00314
Expression system: HEK293 Cells
Length: 27-461, Partial
Activity: ELISA
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7-10 days
Size
QTY
SPR-compatible buffer
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B7-H3 (4Ig) /B7-H3b Protein, Human, Recombinant (His & Avi), Biotinylated
UNQ309, PSEC0249, PRO352, CD276, B7-H3, B7 homolog 3,  4Ig-B7-H3
TMPK-00315
Expression system: HEK293 Cells
Length: 27-461, Partial
Activity: ELISA
  • Inquiry Price
7-10 days
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SPR-compatible buffer
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IL-18R alpha Protein, Human, Recombinant (His & Avi)
IL1RRP, IL-18Ra, IL18Ra, IL18R1, IL-18 R1, IL-18 R α, IL-18 R alpha, IL-1 Rrp, IL-1 R5, CD218a
TMPK-00316
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.8 kDa and the accession number is Q13478.
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer
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IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated
IL1RRP, IL-18Ra, IL18Ra, IL18R1, IL-18 R1, IL-18 R α, IL-18 R alpha, IL-1 Rrp, IL-1 R5, CD218a
TMPK-00317
Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation. IL-18R alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.8 kDa and the accession number is Q13478.
  • Inquiry Price
7-10 days
Size
QTY
SPR-compatible buffer