hcm

Aficamten is a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.

Anti-HCMV gB Antibody (SM5-1) is an antibody targeting HCMV gB and can be used for infectious disease research.

20-HC-Me-Pyrrolidine FA is a potent inhibitor of Aster proteins, inhibiting Aster-A, Aster-B, and Aster-C, and inhibiting Aster protein binding and transfer of cholesterol.20-HC-Me-Pyrrolidine FA can be used in studies of lipid metabolism.20-HC-Me-Pyrrolidine FA is a potent inhibitor of Aster proteins.

BAY-43-9695 is a non-nucleoside compound with anti-human cytomegalovirus (HCMV) activity. It is the major metabolite of BAY-38-4766.

BDCRB inhibits herpesvirus DNA maturation. BDCRB causes the HCMV terminase to skip the normal cleavage site and to continue to package DNA until a second cleavage site is encountered 30 kb further along the concatemer.

Penciclovir (BRL 39123) is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.

20-HC-Me-Pyrrolidine is a potent Aster protein inhibitor with IC50=0.06~0.71 μm for Aster-A, Aster-B, and Aster-C that blocks the ability of Aster proteins to bind and transfer cholesterol, including inhibiting the movement of LDL cholesterol to the endoplasmic reticulum.

Enocitabine is a nucleoside analog. Enocitabine inhibits the replication of human cytomegalovirus(HCMV) and it also has antileukemic and antiviral activities. Enocitabine is also a potent DNA replication inhibitor and a DNA chain terminator.

3-Hydroxy-3'-nitro-2-naphthanilide (IC₅₀ = 12 μM) is an inhibitor of human cytomegalovirus DNA polymerase α. 3-Hydroxy-3'-nitro-2-naphthanilide can be used in infection-related research.

Δ8-THC methyl ether (compound 3) demonstrates a strong docking score of -10.167 kcal/mol for the CB2 receptor. Additionally, Δ8-THC methyl ether exhibits antinociceptive activity in mice.

Maribavir (GW257406X) is an orally available benzimidazole riboside compound with activity against cytomegalovirus (CMV). Maribavir is a selective ATP competitor of the viral UL97 kinase, which is involved in viral nuclear maturation events, such as viral DNA assembly and movement of viral capsids from the nucleus of infected cells. Maribavir has activity against strains of CMV that are resistant to standard anti-CMV agents.

Letermovir (AIC246) (AIC246) is a novel anti-CMV compound (EC50: about 5 nM in fibroblast cells). It targets the pUL56 subunit of the viral terminase complex.

LDC4297 hydrochloride is a selective and efficient CDK7 inhibitor with broad-spectrum antiviral activity. It inhibits herpesvirus, adenovirus, poxvirus, retrovirus, and positive-strand RNA viruses. It can be used for research on viral infections.

Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)

SB-734117 inhibits productive replication of several HCMV strains. SB-734117 exhibited polypharmacology and was an inhibitor of several proteins from the AGC and CMCG kinase groups.

Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.

Tomeglovir is a potent anti-CMV agent, inhibiting the processing of viral DNA-concatemers (IC50s: 0.34/0.039 μM for HCMV and MCMV).

The exo-THC methyl ether is structurally similar to known plant cannabinoids.

ZAK-IN-1 is an orally active and selective inhibitor of the leucine zipper and sterile-alpha motif kinase ZAK, with an IC50 of 4 nM and a KD of 8 nM. It demonstrates exceptional selectivity against 403 types of wild-type kinases. ZAK-IN-1 effectively blocks the p38/GATA-4 and JNK/c-Jun signaling pathways, significantly suppressing cardiac hypertrophy. This compound is applicable in the study of hypertrophic cardiomyopathy (HCM).

PNU-183792 is a 4-oxo-1,4-dihydroquinoline that acts as an orally active inhibitor of herpesvirus polymerases (HSV polymerases). It exhibits broad-spectrum antiviral activity, with IC50 values of 0.69 μM for human cytomegalovirus (HCM), 0.37 μM for varicella-zoster virus, and 0.58 μM for herpes simplex virus (HSV) polymerase. PNU-183792 shows no activity against human α, γ, and δ polymerases but inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV), and rat cytomegalovirus (RCMV).

Myosin-IN-2 (Example 16) is an inhibitor of Myosin ATPase, exhibiting an IC50 value of 1.06 μM. It is applicable in research related to cardiac diseases, including hypertrophic cardiomyopathy (HCM).

Myosin-IN-5 (Example 3) is a myosin inhibitor with an IC50 of 1.84 μM against bovine cardiac myosin. It demonstrates strong selectivity between cardiac and skeletal muscle myosins, exhibiting IC50 values of 43.4 μM for bovine cardiac myofibrils and 1.5 μM for rabbit skeletal muscle myofibrils. This compound is useful in researching hypertrophic cardiomyopathy (HCM).