fluorinated

Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.

6-fluorinated inated-aristeromycin2c showed antiviral activity against heat virus, Zika virus and Sars coronavirus.

Difluorinated H2S probe 1 is a fluorescent probe for hydrogen sulfide (H2S).1It selectively fluoresces in the presence of H2S over Zn2+, Fe3+, S2O32-, ClO-, SO32-, H2O2, NO2-, cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) when used at a concentration of 1 μM. Difluorinated H2S probe 1 displays excitation/emission maxima of 365/450 nm, respectively. 1.Zhang, J., Gao, Y., Kang, X., et al.o,o-Difluorination of aromatic azide yields a fast-response fluorescent probe for H2S detection and for improved bioorthogonal reactionsOrg. Biomol. Chem.15(19)4212-4217(2017)

Perfluorinated SAHA is an HDAC inhibitor for use in cancer treatment regimens, with demonstrated greater antiproliferative properties than SAHA . PFSAHA has also been shown to have higher selectivity for PA3774, an HDAC-like enzyme from P. aeruginosa, as well as other HDACs, which may prove beneficial for developing novel chemotherapeutic treatments for cancer.

Flurocitabine HCl is a fluorinated anhydride analog of cytarabine, which is partially hydrolyzed in vivo to two active antitumor substances (arabinosyl-fluorouracil (ara-FC) and arabinosyl-fluorouracil (ara-FU)).Flurocitabine HCl has demonstrated antitumor activity in phase I studies in acute leukemia and solid tumors.

Piflufolastat (DCFPYL) is a PET imaging agent for prostate cancer PSMA. It is a fluorinated prostate-specific membrane antigen (PSMA) preparation. Piflufolastat can be used to prepare piflufolastat F 18 (DCFPyL F-18).

SR4554 is a fluorinated 2-nitroimidazole non-invasive tumor hypoxia probe for the detection of tumor hypoxia as detected by 19F magnetic resonance spectroscopy (MRS).

Florfenicol (Aquafen) is a fluorinated synthetic analog of thiamphenicol. In the United States, florfenicol is currently used to treat bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus, to treat bovine interdigital phlegmon associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.

Florfenicol (SCH-25298), a fluorinated synthetic analog of thiamphenicol, is currently indicated for the therapy of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Haemophilus somnus, and Pasteurella multocida, for therapy of bovine interdigital phlegmon (foot rot, infectious pododermatitis, acute interdigital necrobacillosis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus. This compound is also used in aquaculture and is approved for use in the United States for the therapy of enteric septicemia in catfish.

Flucytosine (NSC 103805) is a pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity.

Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity.

Fluticasone furoate (Avamys) is a synthetic trifluorinated corticosteroid derived from fluticasone with a Kd of 0.3 nM. Fluticasone furoate has potent anti-inflammatory, anti-asthmatic activity, and low systemic exposure. Fluticasone furoate can be used as a nasal spray for studies about allergic rhinitis treatment.

Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

2,2,2-Trifluoroacetamide is a fluorinated amide commonly used to introduce trifluoromethyl groups or as an acylation reagent, and can be used in biochemical experiments and drug synthesis research.

ONC212 [a fluorinated-ONC201 analogue] is a selective GPR132 agonist.

Hydrazinium hydroxide is a fluorinated carboxylic acid that has been used to study the mechanisms of action of enzymes, hormones and other biomolecules. It has also been used to study the effects of various drugs on the body and to study the effects of environmental toxins on the body.

Fludrocortisone acetate (9α-Fludrocortisone acetate), a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and initiates transcription of glucocorticoid-responsive genes like lipocortins to inhibit phospholipase A2 (PLA2). As the acetate salt of a synthetic fluorinated corticosteroid, it exhibits anti-inflammatory and antiallergic activities. PLA2 inhibition prevents arachidonic acid release, a precursor of eicosanoids such as prostaglandins and leukotrienes, which are key mediators in the pro-inflammatory response. As a mineralocorticoid-receptor agonist, it stimulates Na+ reabsorption, water retention, and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.

Thalidomide-1-Me,5-F is a fluorinated E3 ligase activator utilized for further derivatization through SNAr (nucleophilic aromatic substitution).

Thalidomide-4,5-F is a fluorinated analogue of Thalidomide. Thalidomide enhances protein ubiquitination. The structure can be further derivatized through fluorine substitution.

Tetrafluoro-thalidomide is a fluorinated analog of thalidomide. It acts as an activator of E3 ligase enzymes, facilitating the ubiquitination of proteins for subsequent proteolysis. The structure of tetrafluoro-thalidomide can be further derivatized through fluorine substitution.

Loratadine specified impurity F is a fluorinated analog of Loratadine.

Decafluorobenzophenone is used in the synthesis of fluorinated acridones and acridines. Decafluorobenzophenone alcoholic solution generates radical anion and ketyl which can be studied by electron spin resonance spectra. It undergoes photolysis to form ke

Flopristin, a semi-synthetic antibiotic of the streptogramin A class, is a fluorinated derivative of pristinamycin IIB.

Nemonoxacin is a non-fluorinated quinolone antibiotic.