cpp

(R)-CPP is a NMDA antagonist.

(RS)-CPP is a NMDA antagonist.

Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.

MK 212 hydrochloride is a 5-HT2C receptor agonist

Ac-AAVALLPAVLLALLAP-DEVD-CHO (DEVD-CHO-CPP 32) is a potent and reversible inhibitor of caspase-3 [1].

A11, a cell-penetrating peptide, integrates the HIV-1 Tat protein transduction domain with an 11-amino acid segment from the annexin A1 N-terminus (residues 20-30). This compound disrupts the interaction between annexin A1 and the Eph receptor tyrosine kinase A2 (EphA2), leading to enhanced EphA2 ubiquitination in HK1 nasopharyngeal carcinoma (NPC) cells. At a concentration of 10 µM, A11 curtails proliferation, migration, and invasion of HK1 and 5-8F NPC cells. Furthermore, A11 demonstrably diminishes tumor volume in mouse xenograft models of 5-8F and HK1 NPC in vivo.

(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine/isoleucine and valine in the plasma of wild-type mice.

NLS-CPP is a nuclear localization signal (NLS)-cell penetrating peptide that includes the NLS from OCT6. It facilitates nuclear delivery and can be utilized in the study of chronic inflammatory diseases, including metabolic dysfunction-associated steatohepatitis (MASH) and osteoarthritis (OA).

mNLS-CPP-scramble serves as a negative control peptide for mNLS-CPP-WSTF. It shows potential for research into chronic inflammatory diseases, such as MASH and osteoarthritis.

mNLS-CPP-WSTF is a nuclear localization signal (NLS)-cell penetrating peptide derived from the mouse WSTF sequence. This compound significantly inhibits the interaction between GABARAP and WSTF, WSTF degradation, and the expression of inflammatory genes. It effectively alleviates chronic inflammation, liver fibrosis, and cartilage damage in mouse models of metabolism-associated steatohepatitis (MASH) and osteoarthritis (OA). mNLS-CPP-WSTF shows research potential for chronic inflammatory diseases such as MASH and OA.

mNLS-CPP-WSTFTFA is the trifluoroacetate salt form of mNLS-CPP-WSTF, a cell-penetrating peptide based on the mouse WSTF sequence with a nuclear localization signal (NLS). This compound significantly inhibits the interaction between GABARAP and WSTF, as well as WSTF degradation and the expression of inflammatory genes. It effectively alleviates chronic inflammation, liver fibrosis, and cartilage damage in mouse models of metabolic dysfunction-associated steatotic hepatitis (MASH) and osteoarthritis (OA). mNLS-CPP-WSTF holds research potential for chronic inflammatory diseases such as MASH and OA.

mNLS-CPP-scramble (TFA) is the trifluoroacetate salt form of mNLS-CPP-scramble. Serving as a negative control peptide for mNLS-CPP-WSTF, it holds potential for research in chronic inflammatory diseases, such as MASH and osteoarthritis.

MK-212 is a selective 5-HT1C/5-HT2 agonist that regulates neurotransmitter release by activating central serotonin receptors, commonly used to study appetite control, mood, and neuropsychiatric-related behaviors. MK-212 is widely used in animal models to investigate 5-HT2C receptor-mediated neuropharmacological effects.

CPP-115 is a GABA-aminotransferase inhibitor and a high-affinity vigabatrin analogue.

CPP11G (Compound 11g) is a highly selective inhibitor of NADPH oxidase 2 (Nox2) with an IC50 of 20 μM. It shows potential for research into inflammatory diseases such as vasculitis and atherosclerosis, as well as conditions associated with excessive Nox2 activation, including ischemia-reperfusion injury.

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist, exhibiting a binding affinity with an IC50 of 0.24 nM for the hY5 receptor, and significantly stimulates food intake [1].

CPP2 is a cell-penetrating peptide characterized by its high intracellular translocation efficiency [1].

IRF5-CPP5 is a cell-penetrating peptide that targets homodimerization, selectively inhibiting human IRF5 with IC50 values of 15.4 μM for the recombinant S430D and 15.3 μM for the wild-type (WT) IRF5 monomer dimerization.

CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.

TDCPP (Fyrol FR 2) is classified under the chlorinated trialkyl organophosphate flame retardant (OPFR) group of compounds primarily utilized as additives in commercial products.

CPPG is a potent antagonist of group II/III mGlu receptors. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50: 2.2 nM) over group II (IC50: 46.2 nM) mGlu receptors in the rat cerebral cortex.

CPPD-Q is an antimicrobial and insecticidal agent. It exhibits an EC50 of 6.98 mg/L against Vibrio fischer. CPPD-Q, at doses of 1 or 10 µg/mL, exerts its insecticidal effects by inducing reactive oxygen species (ROS) production in the intestines of Caenorhabditis elegans.

CPPA-TPP (CPPA-Triphenylphosphonium) is a compound linked with the mitochondrial-targeting segment triphenylphosphonium (TPP). It serves a role in synthesizing nanoparticles that release Camptothecin in a reactive oxygen species-dependent manner, ultimately leading to the death of cancer cells.

DDCPPB-Glu is a 6-5 fused ring heterocycle antifolate that shows antitumor activity.