calpain — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2470	MDL-28170	Calpain Inhibitor III	Cysteine Protease , Proteasome
	MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.		Cysteine Protease , Proteasome
T38931	Calpain Inhibitor-1
	Calpain Inhibitor-1 (compound 36) is a highly potent and selective inhibitor of Calpain 1 (Cal1), which is a cysteine protease. It exhibits an IC50 value of 100 nM and a Ki value of 2.89 μM.
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T21949	Calpain Inhibitor XII
	(Rac)-Calpain Inhibitor XII is a reversible and selective inhibitor targeting calpain I (μ-calpain) with a Ki value of 19 nM. It exhibits lower affinities for calpain II (m-calpain, Ki=120 nM) and cathepsin B (Ki=750 nM)...
T72439	Calpain Inhibitor XI
	Calpain Inhibitor XI, a reversible covalent inhibitor of calpain-1, is utilized in the research of neurodegenerative disorders.
T80551	Calpain inhibitor V	Mu-Val-HPh-FMK	Antibiotic
	Calpain Inhibitor V (Mu-Val-HPh-FMK) is a cell-permeable, irreversible calpain inhibitor with demonstrated anti-chlamydial activity [1].		Antibiotic
T63391	Calpain Inhibitor-2
	Calpain Inhibitor-2 is a lipophilic calpain inhibitor, and they showed moderate to good anti-proliferative effects in vitro compared to melanoma cell lines (A-375 and B-16F1) and PC-3 prostate cancer cells. was able to i...
T14187	ALLM	Calpain inhibitor II	Others
	ALLM (Calpain inhibitor II), a potent calpain and cathepsin protease inhibitor, not only prevents neuronal cell death but also enhances chronic neurological function following spinal cord injury (SCI)[1][2].		Others
T63708	Calpain-2-IN-1
	Calpain-2-IN-1 is a selective calpain-2 inhibitor that prolongs ERK activation and thus enhances learning and memory.
T28786	SJA6017	SJA-6017,Calpain Inhibitor VI,Calpain-In-4,SJA 6017,Calpain Inhibitor 4
	SJA6017 is a inhibitor of calpain-1 (IC50 = 7.5 nM) and calpain-2 ( IC50 = 78 nM). SJA6017 also inhibits cathepsins B (IC50s = 15 nM) and cathepsins L (IC50s = 1.6 nM). SJA6017 reduces apoptotic cell death, preserves spi...
T78632	Z-LLY-FMK	Calpain Inhibitor IV	Proteasome
	Z-LLY-FMK (Calpain Inhibitor IV) serves as an inhibitor of calpain, a family of proteases implicated in the apoptosis of various cell systems. Specifically, this compound suppresses intestinal cell apoptosis following co...		Proteasome
T2154	MG-132	Z-LLL-al,Z-Leu-Leu-Leu-CHO	Apoptosis , Proteasome , Autophagy
	MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.		Apoptosis , Proteasome , Autophagy
T9710	Dazcapistat		Cysteine Protease
	Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.		Cysteine Protease
T2493	PD 151746		Cysteine Protease , Proteasome
	PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calp...		Cysteine Protease , Proteasome
T6432	Calpeptin		Apoptosis , Cysteine Protease , Proteasome
	Calpeptin is a potent, cell-permeable calpain inhibitor.		Apoptosis , Cysteine Protease , Proteasome
TP2056L	Acetyl-Calpastatin (184-210)(human) acetate	Acetyl-Calpastatin (184-210) (human) acetate(123714-50-1 Free base )	Cysteine Protease
	Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin L, respectively.		Cysteine Protease
T19384	Isovalerylcarnitine		Apoptosis , Cysteine Protease
	Isovalerylcarnitine (3-methylbutyrylcarnitine) is a small molecule compound produced by the catabolism of L-leucine and the accumulation of isovaleric acid. Isovalerylcarnitine is also a selective and effective calpain a...		Apoptosis , Cysteine Protease
T37753	Aureusimine B		Cysteine Protease , Antibacterial
	Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears to be initiated by a conserved nonribosomal peptide syntheta...		Cysteine Protease , Antibacterial
T60150	(1S,2R)-Alicapistat		Cysteine Protease
	(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound ef...		Cysteine Protease
T6040	Aloxistatin	E64d,Loxistatin,E64c ethyl ester	SARS-CoV , Cysteine Protease
	Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibitor of lysosomal and cytosolic cysteine proteases with...		SARS-CoV , Cysteine Protease