antimycobacterial

Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.

Sulfamoxole (Sulfamoxol) is an antibacterial belonging to sulfonamide.

Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels.

Linaroside exhibited 30% inhibition for antimycobacterial activity against Mycobacterium tuberculosis, strain H(37)Rv at 6.25 microg mL(-1) concentration.

Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica

Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.

Antimycobacterial agent-10 (compound 5) is an inhibitor of DNA gyrase with an IC50 of 96 nM against Mycobacterium tuberculosis gyrase, demonstrating antibacterial properties.

Antimycobacterial agent-1 (compound 33) demonstrates potent antimycobacterial activity against Mycobacterium tuberculosis H37Ra, with a minimal inhibitory concentration (MIC) value of 1 μg ml, and exhibits low cytotoxicity in normal cells, as evidenced by an IC50 value of 143.2 μg ml in Vero cells [1].

Antimycobacterial agent-2 is an effective anti-mycobacterial agent with a MIC99 of 0.8 μM against Mycobacterium tuberculosis (M.tb) H37Rv. Antimycobacterial agent-2 is cytotoxic, acting on CHO cells (IC50: 48.1 μM).

Antimycobacterial agent-3 is an antimycobacterial agent with low cytotoxicity. antimycobacterial agent-3 is effective against sensitive MTB strain H37Rv and resistant clinical isolates (MIC < 0.029-0.110 μ M).

Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting the Mtb DprE1-C387S mutant, with minimal inhibitory concentrations (MIC90) of 0.9 μM for H37Rv and MoxR strains, and 0.5 μM for the DprE1-P116S strain [1].

Antimycobacterial agent-8 (Compound 49) acts as an inhibitor of DNA gyrase (DNA gyrase). It exhibits antibacterial activity, with MIC90 values of 2.5 μM for Mycobacterium tuberculosis and 0.63 μM for M. abscessus. Additionally, Antimycobacterial agent-8 demonstrates effective plasma protein binding in mice.

Ethambutol dihydrochloride (CL40881) is a bacteriostatic antimycobacterial agent, which obstructs the formation of cell wall by inhibiting arabinosyl transferases.

Pyrazinamide (Pyrazinecarboxamide), an antimycobacterial, is utilized therapeutically as an antitubercular agent, which is a synthetic pyrazinoic acid amide derivative.

Rifabutin (LM-427) inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. Rifabutin is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties.

ISOBERGAPTEN is a plant growth regulating substance, it is the principal constituents responsible for the antimycobacterial activity of the roots of Heracleum maximum; it may form an important class of natural defensive agents against fungi.

Ferulenol, a sesquiterpene prenylated coumarin derivative, demonstrates potent antimycobacterial activity and [haemorrhagic] action by selectively targeting succinate ubiquinone reductase within the ubiquinone cycle.

Temafloxacin (Omniflox) is an antibiotic and antimycobacterial agent. It used to treat lower respiratory tract infections, genital and urinary infections like prostatitis, and skin infections.

WAY-299801 is an antibacterial compound that demonstrates significant antimycobacterial activity against various Mycobacterium strains and clinically isolated M. tuberculosis in vitro.

Griselimycin is a natural antimycobacterial product that is currently being pursued as a therapy for tuberculosis.

Kahalalide A has antimycobacterial activity isolated from the mollusk Elysia rufescens.

25-Desacetyl rifampicin is a major active metabolite of the rifamycin antibiotic rifampicin .125-Desacetyl rifampicin is active againstM. smegmatis(MIC99= 2.66 μM). 1.Kigondu, E.M., Njoroge, M., Singh, K., et al.Synthesis and synergistic antimycobacterial screening of chlorpromazine and its metabolitesMed. Chem. Commun.5502-506(2014)

BRD-8000.3 is a narrow-spectrum, bactericidal antimycobacterial agent known for its specific inhibition of EfpA. It exhibits potent activity against wild-type strains and proves to be a valuable tool in tuberculosis research[1].

Pyridomycin is a structurally unusual antimycobacterial cyclodepsipeptide whose composition includes two rare moieties: 3-(3-pyridyl)-L-alanine and 2-hydroxy-3-methylpent-2-enoic acid. It inhibits NADH-dependent enoyl (Acyl-Carrier-Protein) reductase InhA, preventing mycolic acid synthesis in M. tuberculosis, including isoniazid-resistant strains (MICs = 0.31-0.63 μg ml).