Search Result

Search Results for " antihyperglycemic "

Targets

Compounds

Natural Products

Libraries

Cat No.	Product Name	Synonyms	Targets
T26712	AZD-1656	AZD 1656	Glucokinase
	AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2 diabetes.		Glucokinase
T0334	Rosiglitazone	BRL49653	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone (BRL49653) is a PPARγ agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T1502	Vildagliptin	NVP-LAF 237,LAF237	Apoptosis , Ferroptosis , Proteasome , DPP-4
	Vildagliptin (LAF237) is a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolit...		Apoptosis , Ferroptosis , Proteasome , DPP-4
T6646	Rosiglitazone hydrochloride	BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
	Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.		Ferroptosis , TRP/TRPV Channel , PPAR , Autophagy
T1453	Phenformin hydrochloride	Phenformin HCl,Phenethylbiguanide hydrochloride	Potassium Channel , AMPK , Autophagy
	Phenformin hydrochloride (Phenformin HCl) is an agent belonging to the biguanide class of antidiabetics with antihyperglycemic activity.		Potassium Channel , AMPK , Autophagy
T8493	Ingliforib	GPi 296,CP 368296	Phosphorylase
	Ingliforib (CP 368296) is a novel glycogen phosphorylase inhibitor,has antihyperglycemic and cardioprotective properties.		Phosphorylase
T21764	MCC-555	Isaglitazone,Netoglitazone	PPAR
	MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.		PPAR
T3547	Sotagliflozin	LX-4211,LP-802034	SGLT
	Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.		SGLT
T1527	Gliclazide	S1702,SE1702	Potassium Channel
	Gliclazide (SE1702), an oral antihyperglycemic agent, belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating beta-cells of the pancreas to release insulin.		Potassium Channel
T2389	Dapagliflozin	BMS-512148	SGLT , HIF
	Dapagliflozin (BMS-512148) is a selective sodium-glucose co-transporter subtype 2 (SGLT2) inhibitor with antihyperglycemic activity.		SGLT , HIF
T0371	Gliquidone	AR-DF 26,Glurenorm	Potassium Channel
	Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, gliquidone exerts greater binding affinity to SUR1 and increased potency compared...		Potassium Channel
T28560	Ro 16-8714	Ro-16-8714,Ro16-8714
	Ro 16-8714 is an agonist of beta-adrenoreceptor with antihyperglycemic and thermogenic properties.
T68561	ASP-4000 free base
	ASP-4000 free base is a dipeptidyl peptidase 4 (DPP) inhibitor with antihyperglycemic activity.
T15386	Glisoxepide		Others
	Glisoxepide is a sulphonamide derivative and is an orally available nonselective K(ATP) channel blocker. It has antihyperglycemic activity and cardiovascular regulation effect.		Others
T69015	THR-0921
	THR-0921 is a peroxisome proliferator-activated gamma (PPAR gamma) agonist that has antihyperglycemic activity with low adipogenic potential.
T31960	Glymidine	Glycodiazin,Glymidinum,Glycodiazine,Glidiazine
	Glycodiazine is a sulfadiazine derivative with antihyperglycemic activity. Glycanamidine can lower blood sugar levels by increasing insulin release from pancreatic beta cells and increasing peripheral tissue sensitivity ...
T24164	Indanorex	JL-11698,Dietor,JL11698,Indanorexum,JL 11698
	Indanorex is a stimulant drug. It has appetite suppressant effects and also has antihyperglycemic effects.
T61076	Vildagliptin dihydrate
	Vildagliptin dihydrate (LAF237 dihydrate) is a powerful and stable dipeptidyl peptidase IV (DPP-IV) inhibitor, demonstrating selectivity with an IC50 of 3.5 nM in human Caco-2 cells. This compound exhibits exceptional or...
T15505	HSK0935	HSK 0935,HSK-0935	SGLT
	HSK0935 is a highly selective and orally available SGLT2 inhibitor (IC50: 1.3 nM). It has antihyperglycemic activities.		SGLT
T73779	5β-Androstan-3β-ol-17-one
	5β-Androstan-3β-ol-17-one (3β-Etiocholanolone; 5β-Epiandrosterone), a 5β-reduced steroid and a significant metabolic derivative of dehydroepiandrosterone (DHEA), demonstrates potent antihyperglycemic actions in C57BL/KsJ...
T76310	Acetyl Gastric Inhibitory Peptide (human)
	Acetyl Gastric Inhibitory Peptide (human), a fatty acid-derivatized analog of glucose-dependent insulinotropic polypeptide, exhibits enhanced antihyperglycemic and insulinotropic characteristics. This compound is utilize...
T78543	Acetyl Gastric Inhibitory Peptide (human) TFA	Human N-acetyl GIP TFA
	Acetyl Gastric Inhibitory Peptide (human) TFA, a fatty acid-derivatized analog of the glucose-dependent insulinotropic polypeptide, exhibits enhanced antihyperglycemic and insulinotropic properties. It is utilized in the...

Compounds

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Vildagliptin

T1502

Synonym: NVP-LAF 237,LAF237

Target: Apoptosis, Ferroptosis, Proteasome, DPP-4

Rosiglitazone hydrochloride

T6646

Synonym: BRL-49653 HCl,Rosiglitazone HCl

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Phenformin hydrochloride

T1453

Synonym: Phenformin HCl,Phenethylbiguanide hydrochloride

Target: Potassium Channel, AMPK, Autophagy

Ingliforib

T8493

Synonym: GPi 296,CP 368296

Target: Phosphorylase

MCC-555

T21764

Synonym: Isaglitazone,Netoglitazone

Target: PPAR

Sotagliflozin

T3547

Synonym: LX-4211,LP-802034

Target: SGLT

Gliclazide

T1527

Synonym: S1702,SE1702

Target: Potassium Channel

Synonym: AR-DF 26,Glurenorm

Target: Potassium Channel

Ro 16-8714

T28560

Synonym: Ro-16-8714,Ro16-8714

Synonym: Glycodiazin,Glymidinum,Glycodiazine,Glidiazine

Target:

Indanorex

T24164

Synonym: JL-11698,Dietor,JL11698,Indanorexum,JL 11698

Target:

Vildagliptin dihydrate

Synonym: HSK 0935,HSK-0935

Target: SGLT

5β-Androstan-3β-ol-17-one

T73779

Synonym:

Target:

Acetyl Gastric Inhibitory Peptide (human)

T76310

Synonym:

Target:

Acetyl Gastric Inhibitory Peptide (human) TFA

T78543

Synonym: Human N-acetyl GIP TFA

Target:

Cat No.	Product Name	Synonyms	Targets
T0247	Acarbose	BAY g 5421	Glucosidase
	Acarbose (BAY g 5421) is an inhibitor of α-Glucosidases with antihyperglycemic activity.		Glucosidase
T3675	1-Deoxynojirimycin	Duvoglustat,Moranoline,moranolin	PI3K , Glucosidase
	1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.		PI3K , Glucosidase
T21344	1-Deoxynojirimycin hydrochloride	Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin	PI3K , Antibacterial , Antibiotic , Glucosidase
	1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is used to suppress the elevation of postprandial hyperglycemia.		PI3K , Antibacterial , Antibiotic , Glucosidase
TN1026	Vomicine		Others
	Vomicine is a natural product from Strychnos nux-vomica, the S. nux-vomica extracts show antihyperglycemic activity in experimental animals.		Others
T1529	Miglitol	BAY1099,BAY-m1099	Others
	Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity.		Others
T5743	Gymnemagenin		Liver X Receptor
	Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.		Liver X Receptor
T6S1371	Isovitexin	Homovitexin,Saponaretin,Apigenin-6-C-Glucoside	NF-κB , JNK , Glucosidase
	1. Isovitexin (Apigenin-6-C-Glucoside) exhibits a potential antioxidant activity. 2. Isovitexin shows a strong antihyperglycemic action, inhibits α-glucosidase in vivo.		NF-κB , JNK , Glucosidase
T7846	Aegeline		Others , Antifungal
	Aegeline is an alkaloidal-amide, isolated from the leaves of Aegle marmelos and have shown antihyperglycemic as well as antidyslipidemic activities in the validated animal models of type 2 diabetes mellitus.		Others , Antifungal
T7448	4-Hydroxyisoleucine	4-Hydroxy-L-isoleucine	Others
	4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) has antidepressant-like, antidyslipidemic, and antihyperglycemic effects. It displays an insulinotropic activity.		Others
TN1334	7-Methoxyrosmanol	7-O-Methylrosmanol	cAMP
	7-Methoxyrosmanol (7-O-Methylrosmanol) can effectively suppress FSK-induced luciferase expression under the control of the CRE, PEPCK-C and G6Pase gene promoters, it may contribute to its antihyperglycemic activity.		cAMP
TN2247	Swertisin		Adenosine Receptor
	Swertisin, a novel herbal biomolecule, shows a strong antihyperglycemic action. Swertisin is an adenosine A1 receptor antagonist, is known to have antidiabetic, anti-inflammatory and antioxidant effects.		Adenosine Receptor
T3S2072	3-Butylidenephthalide	Butylidene phthalide,n-Butylidenephthalide	Parasite , Glucosidase
	1. 3-Butylidenephthalide (Butylidene phthalide) has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(5) 2.35 mM) in a noncompetitiv...		Parasite , Glucosidase
T3415	Secoisolariciresinol diglucoside	LGM2605	ROS
	Secoisolariciresinol diglucoside (LGM2605) was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol diglucoside (25 mg/kg b.w.) exerts the antihyperglycemic effect ...		ROS
T2909	Fraxetin	7,8-dihydroxy-6-methoxy coumarin	Apoptosis , Others
	Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a m...		Apoptosis , Others
TN4584	Morolic acid		IL Receptor , COX , HIV Protease
	Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediat...		IL Receptor , COX , HIV Protease
T75493	Ellipyrone B
	Ellipyrone B, a γ-pyrone-based macrocyclic polyketide with antihyperglycemic properties, demonstrates inhibitory activity against dipeptidyl peptidase-4 (IC 50 =0.48 mM) [1].
TN4585	Moronic acid		HIV Protease , Antifection , HSV
	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. ...		HIV Protease , Antifection , HSV
T60692	Masoprocol
	Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active inhibitor of lipoxygenase. Masoprocol exhibits antihyperglycemic activity that has the potential for the type II diabetes research. In vivo, Masop...

Natural Products

Synonym: Duvoglustat,Moranoline,moranolin

Target: PI3K, Glucosidase

1-Deoxynojirimycin hydrochloride

T21344

Synonym: Moranoline,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin

Target: PI3K, Antibacterial, Antibiotic, Glucosidase

Synonym: BAY1099,BAY-m1099

Target: Liver X Receptor

Isovitexin

T6S1371

Synonym: Homovitexin,Saponaretin,Apigenin-6-C-Glucoside

Target: NF-κB, JNK, Glucosidase

Aegeline

T7846

Synonym:

Target: Others, Antifungal

4-Hydroxyisoleucine

T7448

Synonym: 4-Hydroxy-L-isoleucine

Target: Others

7-Methoxyrosmanol

TN1334

Synonym: 7-O-Methylrosmanol

Target: Adenosine Receptor

3-Butylidenephthalide

T3S2072

Synonym: Butylidene phthalide,n-Butylidenephthalide

Target: Parasite, Glucosidase

Secoisolariciresinol diglucoside

Synonym: 7,8-dihydroxy-6-methoxy coumarin

Target: Apoptosis, Others

Morolic acid

TN4584

Synonym:

Target: IL Receptor, COX, HIV Protease

Target: HIV Protease, Antifection, HSV

Cat No.	Product Name
L6110	Alkaloid Natural Product Library		468 compounds
	A unique collection of 468 natural alkaloids can be used for high throughput and high content screening；

Libraries

Alkaloid Natural Product Library

L6110

Compounds: 468