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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T40541 | α-Synuclein (61-75) | ||
α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disea... | |||
T4659 | ELN484228 | Others | |
ELN484228 is a α-synuclein blocker. α-synuclein is a key protein in Parkinson’s disease. | |||
T7441 | Cuminaldehyde | Cuminic aldehyde,Cuminal | Endogenous Metabolite |
Cuminaldehyde (Cuminal) is a natural aldehyde with inhibitory effect on alpha-synuclein fibrillation and cytotoxicity. Cuminaldehyde shows anticancer activity,with a pleasant smell and contributes to the aroma of essenti... | |||
T5S0658 | Corynoxine | Autophagy | |
Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla. It is an autophagy enhancer that promotes α-synuclein clearance through the Akt/mTOR pathway. | |||
T76861 | Cinpanemab | BIIB054 | Others |
Cinpanemab (BIIB054) is a novel human monoclonal antibody with affinity for alpha-synuclein residues 1-10. Cinpanemab can be used to study Parkinson's disease and related diseases. | |||
T63321 | 20S Proteasome activator 1 | Proteasome | |
20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o... | |||
T5S2357 | Acetylcorynoline | (+)-Corynoline Acetate,O-Acetylcorynoline | Antifungal |
1. Acetylcorynoline (O-Acetylcorynoline) has antifungal、anti-inflammatory activity. 2. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. 3... | |||
T61404 | α-Synuclein inhibitor 3 | ||
α-Synuclein inhibitor 3 (Compound 7g) is a potent inhibitor of α-synuclein (α -Syn) aggregation. It has potential applications in Parkinson's disease research [1]. | |||
T83726 | Tat-βsyn-degron TFA | ||
Tat-βsyn-degron, an α-synuclein knockdown peptide, integrates three domains: the HIV-1 Tat plasma membrane transduction domain, an α-synuclein binding domain (βsyn) representing amino acids 36-45 of β-synuclein, and a pr... | |||
T72962 | Sycosterol A | ||
Sycosterol A is an α-synuclein (α-syn) inhibitory sterol . | |||
T61611 | α-Synuclein inhibitor 4 | ||
α-Synuclein inhibitor 4 (compound 3gh) is a highly effective and blood-brain barrier-permeable inhibitor of α-Synuclein aggregation. It displays potent activity, with an IC50 value of 0.98 μM, and exhibits a remarkable i... | |||
T62226 | Dyrk1A/α-synuclein-IN-2 | ||
Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual inhibitor of Dyrk1A and α-synuclein aggregation that acts on α-synuclein (IC50: 7.8 μM). Dyrk1A/α-synuclein-IN-2 has a high predictive CNS permeability and neuroprotective... | |||
T61644 | α-Synuclein inhibitor 6 | ||
α-Synuclein inhibitor 6 (compound 3ge) is a highly effective and blood-brain barrier-permeable inhibitor that targets the aggregation of α-Synuclein (α-Syn). It exhibits a potent inhibitory activity, with an IC50 value o... | |||
T81031 | Tau protein/α-synuclein-IN-1 | ||
Tau protein/α-synuclein-IN-1 is a dual inhibitor that not only impedes tau protein and α-synuclein but also reduces the development of α-syn inclusions in M17D neuroblastoma cells, making it a useful agent in the study o... | |||
T76199 | α-Synuclein (61-75) (TFA) | ||
α-Synuclein (61-75) TFA is a fragment (residues 61-75) of the abundant neuronal protein α-Synuclein, which is predominantly located in presynaptic nerve terminals. α-Synuclein serves as a potential biomarker for Parkinso... | |||
T13049 | Synucleozid | NSC 377363 | Others |
Synucleozid is a potent the SNCA mRNA inhibitor that encodes α-synuclein protein (IC50=1.5 μM), has the potential for the investigation of Parkinson’s disease. | |||
T79250 | PROTAC α-synuclein degrader 5 | PROTACs | |
PROTAC α-synuclein degrader 5 is a highly selective (PROTAC) compound that targets and degrades α-synuclein aggregates, exhibiting an DC50 value of 7.51 μM and achieving a maximum degradation rate (Dmax) of 89%. The comp... | |||
T78629 | PROTAC α-synuclein degrader 3 | PROTACs | |
PROTAC α-synuclein degrader 3 (compound 5) serves as a potent and selective agent for degrading α-synuclein and is utilized in Parkinson's disease research [1]. | |||
T62096 | Dyrk1A/α-synuclein-IN-1 | ||
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual inhibitor of Dyrk1A (IC50: 177 nM) and α-synuclein aggregation (IC50: 10.5 μM). CNS permeability and neuroprotective activity. | |||
T62131 | α-Synuclein inhibitor 5 | ||
α-Synuclein inhibitor 5 is a potent inhibitor of α-Synuclein (α-Syn) aggregation across the blood-brain barrier (IC50: 1.22 μM), with 94.3% inhibition at 30 μM. |