idh1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2043	Mutant IDH1-IN-1	IDH1-IN-1	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T16161	Mutant IDH1 inhibitor		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T12128	Mutant IDH1-IN-2		Isocitrate Dehydrogenase (IDH)
	Mutant IDH1-IN-2 is a mutant Isocitrate dehydrogenase (IDH) proteins inhibitor		Isocitrate Dehydrogenase (IDH)
T39716	Mutant IDH1-IN-6	Mutant IDH1-IN-6
	Mutant IDH1-IN-6 is an orally active compound that effectively inhibits mutant isocitrate dehydrogenase (IDH) enzymes. It demonstrates potency and selectivity, with IC50 values of 6.27, 3.71, 36.9, and 11.5 nM for IDH1 R...
T11612	IDH1 Inhibitor 3		Others
	IDH1 Inhibitor 3 is a mutant isocitric dehydrogenase 1 (IDH1) inhibitor (IC50: 45 nM for IDH1R132H).		Others
T11611	IDH1 Inhibitor 2		Dehydrogenase
	IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).		Dehydrogenase
T11613	IDH1 Inhibitor 1		Others
	IDH1 Inhibitor 1 is an orally bioavailable, brain-penetrant, and selective mutant IDH1 inhibitor (IC50s: 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT).		Others
T12129	Mutant IDH1-IN-4		Others
	Mutant IDH1-IN-4 is an mutant Isocitrate dehydrogenase 1 (IDH 1) inhibitor.		Others
T62725	IDH1 Inhibitor 5
	IDH1 Inhibitor 5 (compound 2) is an inhibitor of IDH1 (isocitrate dehydrogenase 1), which inhibits MOG cells (IC50: 64.4 nM) and wild-type IDH1 glioma cells expressing exogenous mutant IDH1 R132H protein (IC50: 34.9 nM).
T78758	IHMT-IDH1-053		Isocitrate Dehydrogenase (IDH)
	IHMT-IDH1-053 (compound 16) is an irreversible inhibitor exhibiting high selectivity for the IDH1 R132H mutant, achieving an IC50 of 4.7 nM. It preferentially targets IDH1 mutants over wild-type IDH1 and IDH2, both wild-...		Isocitrate Dehydrogenase (IDH)
T72705	IDH1 Inhibitor 7
	IDH1 Inhibitor 7 is an IDH1 inhibitor with an IC 50 of less than 100 nM .
T63403	WT IDH1 Inhibitor 2
	WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor (IC50: 120 nM) and is a mutant R132H IDH1 inhibitor, an isoform of GSK321 with wild-type cross-reactivity.
T63402	(S,R)-WT IDH1 Inhibitor 2
	(S,R)-WT IDH1 Inhibitor 2 is a selective and potent mutant IDH1 inhibitor that inhibits R132G (IC50: 2.9 nM), R132C (IC50: 3.8 nM), R132H (IC50: 4.6 nM) and WT IDH1 (IC50: 46 nM) with 100-fold higher selectivity than IDH...
T6820	D-α-Hydroxyglutaric acid disodium	D-alpha-Hydroxyglutaric acid disodium salt,Disodium (R)-2-Hydroxyglutarate	ATPase , Others , Reactive Oxygen Species , Endogenous Metabolite , mTOR
	D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases with Ki of 0.628 mM.
T62698	MIDH1-IN-1
	mIDH1-IN-1 (compound 43) is a potent and selective inhibitor of mIDH1 (isocitrate dehydrogenase 1 mutant) (IC50: 961.5 nM). mIDH1-IN-1 effectively inhibits the production of 2-HG (2-hydroxyglutarate) in HT1080 cells (EC5...
T15551	IDH889		Dehydrogenase
	IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μM, and 1.38 μM for IDH1R132H, IDH1R132C, and IDH1wt).		Dehydrogenase
T15550	IDH-305		Dehydrogenase
	IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (...		Dehydrogenase
T16384	Olutasidenib	FT-2102	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain penetrant, and selective inhibitor of the mutant Iso...		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T3617	Ivosidenib	AG-120	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a mutated form of IDH1 in the cytoplasm, which inhi...		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T2104	AGI-5198	IDH-C35	Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	AGI-5198 (IDH-C35) is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).		Dehydrogenase , Isocitrate Dehydrogenase (IDH)