CPP

(S)-CPP sodium serves as an inhibitor of the branched-chain α-keto acid dehydrogenase complex (BCKDC) kinase, commonly referred to as BDK or keto acid dehydrogenase kinase. As a negative regulator of BCKDC activity, (S)-CPP (IC50 of 6.3 μM) inhibits BDK, which activates the complex, leading to a significant reduction in the levels of leucine isoleucine and valine in the plasma of wild-type mice.

(R)-CPP is a NMDA antagonist.

(RS)-CPP is a NMDA antagonist.

CPP-115 is a GABA-aminotransferase inhibitor and a high-affinity vigabatrin analogue.

CPPHA, a positive allosteric modulator of glutamate receptors mGluR5 and mGluR1, is commonly used in development for central nervous system diseases.

TDCPP (Fyrol FR 2) is classified under the chlorinated trialkyl organophosphate flame retardant (OPFR) group of compounds primarily utilized as additives in commercial products.

Potent, selective peptide agonist for the neuropeptide Y Y5 receptor (IC50 values for inhibition of NPY binding to human Y5, Y1, Y2 and Y4 receptors are 0.24, 530, > 500, and 51 nM respectively, Ki at Y5 = 0.1 - 0.15 nM). Stimulates food intake in vivo.

CPPG is a potent antagonist of group II III mGlu receptors. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50: 2.2 nM) over group II (IC50: 46.2 nM) mGlu receptors in the rat cerebral cortex.

CPPD-Q is an antimicrobial and insecticidal agent. It exhibits an EC50 of 6.98 mg L against Vibrio fischer. CPPD-Q, at doses of 1 or 10 µg mL, exerts its insecticidal effects by inducing reactive oxygen species (ROS) production in the intestines of Caenorhabditis elegans.

DDCPPB-Glu is a 6-5 fused ring heterocycle antifolate that shows antitumor activity.

DMA-CPPTL is a prodrug of CPPTL which induces apoptosis in a dose-dependent manner via the ROS/JNK pathway in acute myeloid leukemia.

4-CPPC is an inhibitor of macrophage migration inhibitory factor-2 (MIF-2; IC50= 27 μM).1It is selective for MIF-2 over MIF-1 (IC50= 450 μM). It inhibits MIF-2, but not MIF-1, binding to CD74in vitrowhen used at a concentration of 10 μM. 4-CPPC (5, 10, and 25 μM) inhibits MIF-2-induced ERK1 2 phosphorylation in primary human skin fibroblasts. 1.Tilstam, P.V., Pantouris, G., Corman, M., et al.A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activityJ. Biol. Chem.294(49)18522-18531(2019)

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist, exhibiting a binding affinity with an IC50 of 0.24 nM for the hY5 receptor, and significantly stimulates food intake [1].

CPP2 is a cell-penetrating peptide characterized by its high intracellular translocation efficiency [1].

Fe(III)(TDCPP) chloride is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

FeTCPP chloride (Iron(III) meso-Tetra(4-carboxyphenyl)porphine chloride) is a metalloporphyrin compound characterized by a central iron ion (Fe3+) coordinated with four 4-carboxyphenylporphine (TCPP) ligands. It serves as a catalyst in catalysis, electrochemical, photochemical, and biomedical research. Under visible light, FeTCPP chloride exhibits high photocatalytic efficiency towards p-nitrophenol. Additionally, it possesses peroxidase-like activity, making it useful in biomimetic catalysis studies.

3-Chloropropiophenone (CPP) is a synthetic compound that is used in the synthesis of organic reagents, pharmaceuticals, and other products. It has the ability to inhibit certain enzymes (e.g. cytochrome P450) and inhibit the growth of certain tumor cells.

MK 212 hydrochloride is a 5-HT2C receptor agonist

TAT (47-57), FAM-labeled, is a cell-penetrating peptide (CPP) with significant potential for intracellular drug delivery research [1].

TAT (47-57) GGG-Cys(Npys) is a cell-penetrating peptide (CPP) with potential applications in intracellular drug delivery research [1].

FITC-LC-TAT (47-57), a fluorescein isothiocyanate (FITC)-labeled trans-activator of transcription (TAT) peptide, is recognized as a cell-penetrating peptide (CPP) and enhances the yield and solubility of heterologous proteins [1].

CGP 37849 is a competitive orally active N-methyl-D-aspartate (NMDA) receptor antagonist ((Ki = 35 nM)) with potency.CGP 37849 is an anticonvulsant in rodents and also has antidepressant and anxiolytic properties.

Grb2 SH2 Domain Inhibitor 1 TFA is a cyclic cell-penetrating peptide (CPP) featuring a conformationally restricted d-pro-l-pro motif ring (AF Φ Rpprrfq), where Φ represents L-naphthylalanine, R signifies D-arginine, and P stands for D-proline. It primarily functions as a cyclic peptide inhibitor.

Nona-L-arginine (Arg)9 acetate, a cell-penetrating peptide (CPP) consisting of 9 arginine residues, displays neuroprotective properties, with an IC50 of 0.78 μM in the glutamic acid model [1] [2].