bcl-xl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T38622	Bcl-xL antagonist 2		BCL
	Bcl-xL antagonist 2 is an effective and selective antagonist of Bcl-xL with an IC50 of 91 nM and a Ki of 65 nM. Bcl-xL antagonist 2 induces apoptosis in cancer cells and can be used in studies about chronic lymphocytic l...		BCL
T10483	Lisaftoclax	Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) is an oral dual inhibitor of Bcl-2 and Bcl-xl, with IC50 values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively. Lisaftoclax is used to treat chronic lymphocytic leukemia (CLL...		BCL
T33467	MOMIPP		PI3K
	MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2].		PI3K
T18363	Monoethyl pimelate		Others , PROTAC Linker
	Monoethyl pimelate is a *PROTAC linker, which refers to the alkyl/ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader[1].*		Others , PROTAC Linker
T80221	TAT-BH4 (Bcl-xL)		Apoptosis
	TAT-BH4 (Bcl-xL), primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an N-terminal eosin-labeled cysteine and the protein transduction domain of the HIV TAT protein (amino aci...		Apoptosis
T73999	PROTAC Bcl-xL degrader-3
	PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.
T74138	PROTAC Bcl-xL degrader-2
	PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.
T80222	TAT-BH4 (Bcl-xL) (TFA)		Apoptosis
	"TAT-BH4 (Bcl-xL) TFA, primarily localized at the mitochondria, inhibits apoptotic cell death. This compound comprises an eosin-labeled cysteine at the N-terminal and the protein transduction domain from the HIV TAT prot...		Apoptosis
T74137	PROTAC Bcl-xL ligand-1
	PROTAC Bcl-xL ligand-1 serves as a ligand targeting Bcl-xL, essential in synthesizing PROTACs [1].
T73957	PROTAC Bcl-xL degrader-1
	PROTAC Bcl-xL degrader-1 is a potent PROTAC composed of a Bcl-xL (Bcl-2 family member) ligand-binding group, a linker, and an IAP E3 ligases binding group, demonstrating effectiveness as a Bcl-xL degrader. It exhibits to...
T12412L	PDK4-IN-1 hydrochloride		Apoptosis , PDK
	PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)		Apoptosis , PDK
T8656	CAY10404	3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis , Akt , COX
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSC-LC cel...		Apoptosis , Akt , COX
T6748	A-1155463	A 1155463,A1155463	BCL
	A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).		BCL
T14071	A-385358		BCL
	A-385358 is a selective Bcl-xL inhibitor with Kis of 0.80 nM for Bcl-xL and 67 nM for Bcl-2, respectively.		BCL
T6281	TW-37	TW 37	BCL
	TW-37 is an nonpeptide inhibitor to recombinant Bcl-2, Bcl-xL and Mcl-1 (Ki: 0.29/1.11/0.26 μM).		BCL
T2730	Gossypol (acetic acid)	(±)-Gossypol-acetic acid,Pogosin,AT101,Gossypol acetic acid	BCL
	Gossypol acetic acid (AT101), a polyphenolic compound isolated from cottonseeds, binds with Bcl-2, Bcl-xL, Mcl-1, and does not inhibit BIR3 domain and BID.		BCL
T6650	Sabutoclax	BI-97C1	BCL
	Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.		BCL
T6185	Gambogic Acid	Beta-Guttiferrin,Guttatic Acid,Guttic Acid	BCL , Autophagy
	Gambogic Acid (Guttic Acid) ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 ...		BCL , Autophagy
T2099	ABT-737		Mitophagy , BCL , Autophagy
	ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w (EC50s: 78.7/30.3/197.8 nM).		Mitophagy , BCL , Autophagy
T2101	Navitoclax	ABT-263	BCL
	Navitoclax (ABT-263) is a Bcl-2 inhibitor that binds to Bcl-xL, Bcl-2, and Bcl-w proteins (Ki<1 nM) with potent and oral activity. Navitoclax has antitumor activity and induces apoptosis.		BCL